Ltb4r2 leukotriene B4 receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ltb4r2provided by RGD
Official Full Name: leukotriene B4 receptor 2provided by RGD
Primary source: RGD:621029
See related: Ensembl:ENSRNOG00000020382 AllianceGenome:RGD:621029
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LTB4-R2
Summary: Predicted to enable G protein-coupled peptide receptor activity and leukotriene B4 receptor activity. Predicted to be involved in inflammatory response and neuropeptide signaling pathway. Predicted to act upstream of or within keratinocyte migration and signal transduction. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human LTB4R2 (leukotriene B4 receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 1.6), Thymus (RPKM 1.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (33228634..33230453)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (29258712..29260531)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (34446478..34448220)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BLT1 and BLT2 were involved in synovial cell proliferation.
Title: [Involvement of leukotrine B4 receptors in the inflammatory responses and immunological regulation in vitro].

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene B4 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene B4 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within keratinocyte migration	ISO Inferred from Sequence Orthology more info
involved_in leukotriene signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leukotriene B4 receptor 2

Names: LTB4 receptor JULF2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053640.2 → NP_446092.1 leukotriene B4 receptor 2

See identical proteins and their annotated locations for NP_446092.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

Q924U0

UniProtKB/TrEMBL

A6KH51

Related

ENSRNOP00000027619.1, ENSRNOT00000027619.3

Conserved Domains (2) summary

cd14964
Location:22 → 48

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:21 → 300

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily