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Ugt1a6 UDP glucuronosyltransferase family 1 member A6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 113992, updated on 30-Mar-2024

Summary

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Official Symbol
Ugt1a6provided by RGD
Official Full Name
UDP glucuronosyltransferase family 1 member A6provided by RGD
Primary source
RGD:620949
See related
Ensembl:ENSRNOG00000018740 AllianceGenome:RGD:620949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ugt1; Udpgt; Ugt1a7; UDPGT 1-6
Summary
Enables glucuronosyltransferase activity. Involved in several processes, including 4-chlorobiphenyl metabolic process; cellular response to glucocorticoid stimulus; and response to lipopolysaccharide. Located in intracellular membrane-bounded organelle. Part of protein-containing complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human UGT1A6 (UDP glucuronosyltransferase family 1 member A6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1922.0), Kidney (RPKM 1019.5) and 3 other tissues See more
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Genomic context

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Location:
9q35
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (96195018..96256264)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88747213..88808465)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (95241609..95302822)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 40 Neighboring gene UDP glucuronosyltransferase family 1 member A9 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A9, pseudogene Neighboring gene uncharacterized LOC108351970 Neighboring gene UDP glucuronosyltransferase family 1 member A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glycosyltransferase 1 family, polypeptide A4, pseudogene Neighboring gene UDP glucuronosyltransferase family 1 member A5 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase family 1 member A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene Holliday junction recognition protein Neighboring gene transient receptor potential cation channel, subfamily M, member 8 Neighboring gene peptidylprolyl isomerase D, pseudogene 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effects of β-Naphthoflavone on Ugt1a6 and Ugt1a7 Expression in Rat Brain. Sakakibara Y, et al. Biol Pharm Bull, 2016. PMID 26725430
  2. Regulation of the rat UGT1A6 by glucocorticoids involves a cryptic glucocorticoid response element. Falkner KC, et al. Drug Metab Dispos, 2008 Feb. PMID 18039810, Free PMC Article
  3. Activation of glucuronidation through reduction of a disulfide bond in rat UDP-glucuronosyltransferase 1A6. Ikushiro S, et al. Biochemistry, 2002 Oct 22. PMID 12379124
  4. Molecular basis of perinatal changes in UDP-glucuronosyltransferase activity in maternal rat liver. Luquita MG, et al. J Pharmacol Exp Ther, 2001 Jul. PMID 11408524
  5. Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase. Iyanagi T, et al. J Biol Chem, 1986 Nov 25. PMID 3096993

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bile duct ligation elevates 5-HT levels in cerebral cortex of rats partly due to impairment of brain UGT1A6 expression and activity via ammonia accumulation.
    Title: Bile duct ligation elevates 5-HT levels in cerebral cortex of rats partly due to impairment of brain UGT1A6 expression and activity via ammonia accumulation.
  2. study indicated that Status Epilepticus altered the expression of brain Ugt1a1 and Ugt1a7, which could alter glucuronidation in the brain.
    Title: Effect of status epilepticus on expression of brain UDP-glucuronosyltransferase 1a in rats.
  3. This study clarified that Ugt1a6 and Ugt1a7 mRNA expression and their enzyme activities were altered by beta-naphthoflavone, suggesting that these changes may lead to alteration in the pharmacokinetics of UGT substrate in rat brain.
    Title: Effects of β-Naphthoflavone on Ugt1a6 and Ugt1a7 Expression in Rat Brain.
  4. results indicate that adrenal-dependent factors such as glucocorticoids are partially involved in the basal regulation of UGT1A6 and UGT1A7 transcription.
    Title: Effect of adrenalectomy on expression and induction of UDP-glucuronosyltransferase 1A6 and 1A7 in rats.
  5. Catalytic properties/expression of UGT1A6/7 are influenced by the pro-oxidant environment in astrocytes.
    Title: Effect of oxidative stress on UDP-glucuronosyltransferases in rat astrocytes.
  6. We present for the first time evidences that the choroids plexus express transcripts for both UGT1A6 and NADPH-cytochrome P450 reductase
    Title: Drug metabolizing enzyme expression in rat choroid plexus: effects of in vivo xenobiotics treatment.
  7. These results indicate that the expression of extrahepatic UDP-glucuronosyltransferases UGT1a1 and UGT1a6 is isoform-specific and regulated differentially in tissues by the pituitary gland.
    Title: Effects on extrahepatic UDP-glucuronosyltransferases in hypophysectomized rat.
  8. Data suggest that thyroid hormones and vitamin A are co-regulators of UDP-glucuronosyltransferase (UGT) 1 expression, without affecting the UGT2 family.
    Title: Vitamin A modulates the effects of thyroid hormone on UDP-glucuronosyltransferase expression and activity in rat liver.
  9. The disulfide bond between Cys-121 and Cys-125 of UGT1A6 is responsible for the activation of glucuronidation in hepatic microsomes.
    Title: Activation of glucuronidation through reduction of a disulfide bond in rat UDP-glucuronosyltransferase 1A6.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124929

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables retinoic acid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 4-chlorobiphenyl metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular glucuronidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular glucuronidation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucocorticoid stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to hormone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in liver development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
UDP-glucuronosyltransferase 1-6
Names
A1
P-nitrophenol specific
P-nitrophenol-specific UDPGT
UDP glucuronosyltransferase 1 family, polypeptide A6
UDP glucuronosyltransferase 1A6
UDP glycosyltransferase 1 family, polypeptide A6
UGT1*6
UGT1-06
UGT1.6
NP_001034780.1
NP_476446.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039691.3 → NP_001034780.1  UDP-glucuronosyltransferase 1-6 precursor

    See identical proteins and their annotated locations for NP_001034780.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A6JQH9, F7FJM7, P97886, Q6T5E9
    Related
    ENSRNOP00000030374.4, ENSRNOT00000032634.7
    Conserved Domains (2) summary
    PHA03392
    Location:14 → 504
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:26 → 521
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

  2. NM_057105.3 → NP_476446.2  UDP-glucuronosyltransferase 1-6 precursor

    See identical proteins and their annotated locations for NP_476446.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC120922, BC107931
    UniProtKB/TrEMBL
    A6JQH9, F7FJM7, P97886, Q6T5E9
    Conserved Domains (2) summary
    PHA03392
    Location:14 → 504
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:26 → 521
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    96195018..96256264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08430.1 GenPept UniProtKB/Swiss-Prot:P08430

Gene LinkOut

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