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ADCY7 adenylate cyclase 7 [ Homo sapiens (human) ]

Gene ID: 113, updated on 11-Apr-2024

Summary

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Official Symbol
ADCY7provided by HGNC
Official Full Name
adenylate cyclase 7provided by HGNC
Primary source
HGNC:HGNC:238
See related
Ensembl:ENSG00000121281 MIM:600385; AllianceGenome:HGNC:238
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AC7
Summary
This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013]
Expression
Broad expression in spleen (RPKM 22.5), appendix (RPKM 19.0) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See ADCY7 in Genome Data Viewer
Location:
16q12.1
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (50244699..50318135)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (56042542..56115969)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (50300462..50352046)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900375 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:50186273-50187230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10809 Neighboring gene MPRA-validated peak2589 silencer Neighboring gene terminal nucleotidyltransferase 4B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50217888-50218450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50218451-50219012 Neighboring gene Sharpr-MPRA regulatory region 14159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10810 Neighboring gene Sharpr-MPRA regulatory region 8986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50278238-50278950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50278951-50279662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50280376-50281087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50288095-50288594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50299606-50300199 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50305212-50306046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50306047-50306881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50317845-50318346 Neighboring gene microRNA 6771 Neighboring gene Sharpr-MPRA regulatory region 2137 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:50347343-50348542 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:50353005-50354204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10816 Neighboring gene bromodomain containing 7 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7482 Neighboring gene Sharpr-MPRA regulatory region 13482 Neighboring gene long intergenic non-protein coding RNA 2178

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7. Luo Y, et al. Nat Genet, 2017 Feb. PMID 28067910, Free PMC Article
  2. Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry. Joeyen-Waldorf J, et al. Biol Psychiatry, 2012 Apr 1. PMID 22264442, Free PMC Article
  3. Sex-specific role for adenylyl cyclase type 7 in alcohol dependence. Desrivières S, et al. Biol Psychiatry, 2011 Jun 1. PMID 21481845, Free PMC Article
  4. A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. Beeler JA, et al. Biochemistry, 2004 Dec 14. PMID 15581358
  5. Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase. Yan SZ, et al. Methods Enzymol, 2002. PMID 11665607

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hsa_circ_0008234 facilitates proliferation of cutaneous squamous cell carcinoma through targeting miR-127-5p to regulate ADCY7.
    Title: Hsa_circ_0008234 facilitates proliferation of cutaneous squamous cell carcinoma through targeting miR-127-5p to regulate ADCY7.
  2. CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion.
    Title: CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion.
  3. AC7 and miR-192 might be new biomarkers and therapeutic targets for patients with relapsed acute promyelocytic leukemia.
    Title: Adenylate cyclase 7 regulated by miR-192 promotes ATRA-induced differentiation of acute promyelocytic leukemia cells.
  4. We discovered a 0.6% frequency missense variant in ADCY7.
    Title: Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.
  5. The stronger TNF-alpha responses in young males compared to females may be partly associated with male-specific down-regulation of ADCY7 and ADCY9.
    Title: Higher TNFα responses in young males compared to females are associated with attenuation of monocyte adenylyl cyclase expression.
  6. The ADCY7 deficiency resulted in decreased cell growth, elevated apoptosis, and lower c-Myc expression in cultured leukemia cells obtained from acute myeloid leukemia patients.
    Title: ADCY7 supports development of acute myeloid leukemia.
  7. evidence implicates ADCY7 in the modulation of mood regulatory neural mechanisms and, possibly, risk for and pathophysiology of depression.
    Title: Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry.
  8. we found that single nucleotide polymorphisms in ADCY7 associate with alcohol dependence in women, and these markers are also associated with ADCY7 expression (messenger RNA) levels.
    Title: Sex-specific role for adenylyl cyclase type 7 in alcohol dependence.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetical genomic determinants of alcohol consumption in rats and humans.
  10. soluble adenylyl cyclase is responsive to both CO(2) and bicarbonate ion
    Title: Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The addition of HIV-1 gp120 with TNF-alpha to human B-cells stimulates cAMP production in a dose-dependent manner PubMed
Envelope transmembrane glycoprotein gp41 env Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5 PubMed
Nef nef HIV-1 induces the upregulation of complement factor C3 in astrocytes and neurons through signaling pathways that involve protein kinase C and adenylate cyclase activation, which is an effect that may contribute to the pathogenesis of AIDS in the brain PubMed
Tat tat HIV-1 Tat inhibits adenylyl cyclase activity in microglia and astrocyte cultures from neonatal rat brain, suggesting that Tat inhibition of cAMP synthesis may contribute to neuronal degeneration and cell death associated with HIV infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36387, KIAA0037

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to ethanol IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to lithium ion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in maternal process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
adenylate cyclase type 7
Names
ATP pyrophosphate-lyase 7
adenylate cyclase type VII
adenylyl cyclase 7
NP_001105.1
NP_001272986.1
XP_011521137.1
XP_011521138.1
XP_011521139.1
XP_011521140.1
XP_011521141.1
XP_011521142.1
XP_011521144.1
XP_016878385.1
XP_016878387.1
XP_047289506.1
XP_047289507.1
XP_047289508.1
XP_047289509.1
XP_047289510.1
XP_047289511.1
XP_047289512.1
XP_047289513.1
XP_047289514.1
XP_047289515.1
XP_047289516.1
XP_047289517.1
XP_047289518.1
XP_047289519.1
XP_047289520.1
XP_047289521.1
XP_047289522.1
XP_047289523.1
XP_047289524.1
XP_047289525.1
XP_047289526.1
XP_047289527.1
XP_054235453.1
XP_054235454.1
XP_054235455.1
XP_054235456.1
XP_054235457.1
XP_054235458.1
XP_054235459.1
XP_054235460.1
XP_054235461.1
XP_054235462.1
XP_054235463.1
XP_054235464.1
XP_054235465.1
XP_054235466.1
XP_054235467.1
XP_054235468.1
XP_054235469.1
XP_054235470.1
XP_054235471.1
XP_054235472.1
XP_054235473.1
XP_054235474.1
XP_054235475.1
XP_054235476.1
XP_054235477.1
XP_054235478.1
XP_054235479.1
XP_054235480.1
XP_054235481.1
XP_054235482.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114.5 → NP_001105.1  adenylate cyclase type 7 isoform 1

    See identical proteins and their annotated locations for NP_001105.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA740624, AC007597, BC039891, BC126271, D25538, HY102720
    Consensus CDS
    CCDS10741.1
    UniProtKB/Swiss-Prot
    A0AVA6, P51828
    Related
    ENSP00000501053.1, ENST00000673801.1
    Conserved Domains (4) summary
    smart00044
    Location:224 → 429
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:871 → 1067
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:485 → 592
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:73 → 249
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  2. NM_001286057.2 → NP_001272986.1  adenylate cyclase type 7 isoform 2

    See identical proteins and their annotated locations for NP_001272986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC007597
    Consensus CDS
    CCDS73882.1
    UniProtKB/TrEMBL
    B3KSJ0, F5H4D1
    Related
    ENSP00000457409.2, ENST00000566433.6
    Conserved Domains (4) summary
    smart00044
    Location:224 → 429
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:270 → 432
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:485 → 592
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:73 → 249
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    50244699..50318135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433551.1 → XP_047289507.1  adenylate cyclase type 7 isoform X1

  2. XM_047433560.1 → XP_047289516.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  3. XM_047433552.1 → XP_047289508.1  adenylate cyclase type 7 isoform X1

  4. XM_047433563.1 → XP_047289519.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  5. XM_011522837.4 → XP_011521139.1  adenylate cyclase type 7 isoform X1

    See identical proteins and their annotated locations for XP_011521139.1

    Conserved Domains (4) summary
    smart00044
    Location:224 → 429
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:871 → 1073
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:485 → 592
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:73 → 249
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  6. XM_047433556.1 → XP_047289512.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828
    Related
    ENSP00000254235.3, ENST00000254235.7

  7. XM_047433568.1 → XP_047289524.1  adenylate cyclase type 7 isoform X5

    UniProtKB/TrEMBL
    F5H4D1

  8. XM_011522842.3 → XP_011521144.1  adenylate cyclase type 7 isoform X1

    See identical proteins and their annotated locations for XP_011521144.1

    Conserved Domains (4) summary
    smart00044
    Location:224 → 429
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:871 → 1073
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:485 → 592
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:73 → 249
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  9. XM_047433557.1 → XP_047289513.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  10. XM_011522836.3 → XP_011521138.1  adenylate cyclase type 7 isoform X1

    See identical proteins and their annotated locations for XP_011521138.1

    Conserved Domains (4) summary
    smart00044
    Location:224 → 429
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:871 → 1073
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:485 → 592
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:73 → 249
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  11. XM_047433550.1 → XP_047289506.1  adenylate cyclase type 7 isoform X1

  12. XM_047433559.1 → XP_047289515.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  13. XM_011522840.4 → XP_011521142.1  adenylate cyclase type 7 isoform X1

    See identical proteins and their annotated locations for XP_011521142.1

    Conserved Domains (4) summary
    smart00044
    Location:224 → 429
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:871 → 1073
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:485 → 592
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:73 → 249
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  14. XM_047433555.1 → XP_047289511.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828
    Related
    ENSP00000378187.2, ENST00000394697.7

  15. XM_047433567.1 → XP_047289523.1  adenylate cyclase type 7 isoform X5

    UniProtKB/TrEMBL
    F5H4D1

  16. XM_017022898.2 → XP_016878387.1  adenylate cyclase type 7 isoform X5

    UniProtKB/TrEMBL
    B3KSJ0, F5H4D1
    Conserved Domains (4) summary
    smart00044
    Location:224 → 429
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:270 → 432
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:485 → 592
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:73 → 249
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  17. XM_047433569.1 → XP_047289525.1  adenylate cyclase type 7 isoform X5

    UniProtKB/TrEMBL
    F5H4D1

  18. XM_047433561.1 → XP_047289517.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  19. XM_011522839.3 → XP_011521141.1  adenylate cyclase type 7 isoform X1

    See identical proteins and their annotated locations for XP_011521141.1

    Conserved Domains (4) summary
    smart00044
    Location:224 → 429
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:871 → 1073
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:485 → 592
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:73 → 249
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  20. XM_047433558.1 → XP_047289514.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  21. XM_011522835.3 → XP_011521137.1  adenylate cyclase type 7 isoform X1

    See identical proteins and their annotated locations for XP_011521137.1

    Conserved Domains (4) summary
    smart00044
    Location:224 → 429
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:871 → 1073
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:485 → 592
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:73 → 249
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  22. XM_047433554.1 → XP_047289510.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  23. XM_017022896.1 → XP_016878385.1  adenylate cyclase type 7 isoform X3

  24. XM_047433564.1 → XP_047289520.1  adenylate cyclase type 7 isoform X4

  25. XM_047433570.1 → XP_047289526.1  adenylate cyclase type 7 isoform X6

  26. XM_047433566.1 → XP_047289522.1  adenylate cyclase type 7 isoform X5

    UniProtKB/TrEMBL
    F5H4D1

  27. XM_047433565.1 → XP_047289521.1  adenylate cyclase type 7 isoform X5

    UniProtKB/TrEMBL
    F5H4D1

  28. XM_047433571.1 → XP_047289527.1  adenylate cyclase type 7 isoform X7

  29. XM_047433553.1 → XP_047289509.1  adenylate cyclase type 7 isoform X1

  30. XM_011522838.3 → XP_011521140.1  adenylate cyclase type 7 isoform X1

    See identical proteins and their annotated locations for XP_011521140.1

    Conserved Domains (4) summary
    smart00044
    Location:224 → 429
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:871 → 1073
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:485 → 592
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:73 → 249
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  31. XM_047433562.1 → XP_047289518.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    56042542..56115969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379493.1 → XP_054235468.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  2. XM_054379486.1 → XP_054235461.1  adenylate cyclase type 7 isoform X1

  3. XM_054379496.1 → XP_054235471.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  4. XM_054379484.1 → XP_054235459.1  adenylate cyclase type 7 isoform X1

  5. XM_054379505.1 → XP_054235480.1  adenylate cyclase type 7 isoform X5

    UniProtKB/TrEMBL
    F5H4D1

  6. XM_054379487.1 → XP_054235462.1  adenylate cyclase type 7 isoform X1

  7. XM_054379497.1 → XP_054235472.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  8. XM_054379481.1 → XP_054235456.1  adenylate cyclase type 7 isoform X1

  9. XM_054379490.1 → XP_054235465.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  10. XM_054379478.1 → XP_054235453.1  adenylate cyclase type 7 isoform X1

  11. XM_054379483.1 → XP_054235458.1  adenylate cyclase type 7 isoform X1

  12. XM_054379492.1 → XP_054235467.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  13. XM_054379479.1 → XP_054235454.1  adenylate cyclase type 7 isoform X1

  14. XM_054379489.1 → XP_054235464.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  15. XM_054379503.1 → XP_054235478.1  adenylate cyclase type 7 isoform X5

    UniProtKB/TrEMBL
    F5H4D1

  16. XM_054379501.1 → XP_054235476.1  adenylate cyclase type 7 isoform X5

    UniProtKB/TrEMBL
    F5H4D1

  17. XM_054379504.1 → XP_054235479.1  adenylate cyclase type 7 isoform X5

    UniProtKB/TrEMBL
    F5H4D1

  18. XM_054379494.1 → XP_054235469.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  19. XM_054379500.1 → XP_054235475.1  adenylate cyclase type 7 isoform X5

    UniProtKB/TrEMBL
    F5H4D1

  20. XM_054379506.1 → XP_054235481.1  adenylate cyclase type 7 isoform X6

  21. XM_054379507.1 → XP_054235482.1  adenylate cyclase type 7 isoform X7

  22. XM_054379480.1 → XP_054235455.1  adenylate cyclase type 7 isoform X1

  23. XM_054379488.1 → XP_054235463.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  24. XM_054379499.1 → XP_054235474.1  adenylate cyclase type 7 isoform X4

  25. XM_054379482.1 → XP_054235457.1  adenylate cyclase type 7 isoform X1

  26. XM_054379491.1 → XP_054235466.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828

  27. XM_054379502.1 → XP_054235477.1  adenylate cyclase type 7 isoform X5

    UniProtKB/TrEMBL
    F5H4D1

  28. XM_054379498.1 → XP_054235473.1  adenylate cyclase type 7 isoform X3

  29. XM_054379485.1 → XP_054235460.1  adenylate cyclase type 7 isoform X1

  30. XM_054379495.1 → XP_054235470.1  adenylate cyclase type 7 isoform X2

    UniProtKB/Swiss-Prot
    A0AVA6, P51828
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51828.1 GenPept UniProtKB/Swiss-Prot:P51828

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