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Pecr peroxisomal trans-2-enoyl-CoA reductase [ Mus musculus (house mouse) ]

Gene ID: 111175, updated on 5-Mar-2024

Summary

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Official Symbol
Pecrprovided by MGI
Official Full Name
peroxisomal trans-2-enoyl-CoA reductaseprovided by MGI
Primary source
MGI:MGI:2148199
See related
Ensembl:ENSMUSG00000026189 AllianceGenome:MGI:2148199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TERP; 2400003B18Rik
Summary
Predicted to enable signaling receptor binding activity and trans-2-enoyl-CoA reductase (NADPH) activity. Predicted to be involved in phytol metabolic process. Predicted to act upstream of or within fatty acid elongation. Located in mitochondrion. Is expressed in alimentary system; gland; liver; and pancreas. Orthologous to human PECR (peroxisomal trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 84.9), kidney adult (RPKM 79.9) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C3; 1 36.46 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (72298331..72323480, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (72259172..72284321, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D230017M19 gene Neighboring gene STARR-seq mESC enhancer starr_01271 Neighboring gene STARR-positive B cell enhancer ABC_E5771 Neighboring gene predicted gene, 24497 Neighboring gene predicted gene, 25939 Neighboring gene transmembrane protein 169 Neighboring gene predicted gene, 51631 Neighboring gene STARR-positive B cell enhancer ABC_E4322 Neighboring gene STARR-seq mESC enhancer starr_01273 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 5 Neighboring gene STARR-seq mESC enhancer starr_01274

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Peroxisomal trans-2-enoyl-CoA inhibits proliferation, migration and invasion of hepatocellular carcinoma cells. Luo Q, et al. Acta Histochem, 2023 Feb. PMID 36724637
  2. Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs. Das AK, et al. J Biol Chem, 2000 Aug 11. PMID 10811639
  3. Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology. Amery L, et al. Comb Chem High Throughput Screen, 2001 Nov. PMID 11669066
  4. Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Cossette SM, et al. Biol Open, 2014 Dec 12. PMID 25505152, Free PMC Article
  5. Searching QTL by gene expression: analysis of diabesity. Brown AC, et al. BMC Genet, 2005 Mar 10. PMID 15760467, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Peroxisomal trans-2-enoyl-CoA inhibits proliferation, migration and invasion of hepatocellular carcinoma cells.
    Title: Peroxisomal trans-2-enoyl-CoA inhibits proliferation, migration and invasion of hepatocellular carcinoma cells.
  2. a paper describing the functions of peroxisomal trans 2-enoyl CoA reductase
    Title: Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables trans-2-enoyl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables trans-2-enoyl-CoA reductase (NADPH) activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables trans-2-enoyl-CoA reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables trans-2-enoyl-CoA reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid elongation ISA
Inferred from Sequence Alignment
more info
 PubMed 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phytol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phytol metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisomal trans-2-enoyl-CoA reductase
Names
perosisomal 2-enoyl-CoA reductase
NP_001343445.1
NP_076012.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356516.1 → NP_001343445.1  peroxisomal trans-2-enoyl-CoA reductase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in its' 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC114905, AC120136
    Conserved Domains (1) summary
    cl25409
    Location:2 → 121
    SDR; Short-chain dehydrogenases/reductases (SDR)

  2. NM_023523.6 → NP_076012.3  peroxisomal trans-2-enoyl-CoA reductase isoform 1

    See identical proteins and their annotated locations for NP_076012.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK010260, AK162100, BY286611, CB723327
    Consensus CDS
    CCDS35607.1
    UniProtKB/Swiss-Prot
    Q99MZ7, Q9CX01, Q9JIF4
    UniProtKB/TrEMBL
    Q3UXD9
    Related
    ENSMUSP00000027381.7, ENSMUST00000027381.13
    Conserved Domains (2) summary
    cd05369
    Location:32 → 267
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
    PRK05653
    Location:32 → 267
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    72298331..72323480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MZ7.1 GenPept UniProtKB/Swiss-Prot:Q99MZ7

Gene LinkOut

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