U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DUSP14 dual specificity phosphatase 14 [ Homo sapiens (human) ]

Gene ID: 11072, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
DUSP14provided by HGNC
Official Full Name
dual specificity phosphatase 14provided by HGNC
Primary source
HGNC:HGNC:17007
See related
Ensembl:ENSG00000276023 MIM:606618; AllianceGenome:HGNC:17007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MKP6; MKP-L
Summary
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Expression
Broad expression in thyroid (RPKM 9.3), skin (RPKM 8.7) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (37488566..37513498)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (38472550..38500180)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (35849997..35873600)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene acetyl-CoA carboxylase alpha Neighboring gene chromosome 17 open reading frame 78 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35768105-35768789 Neighboring gene transcriptional adaptor 2A Neighboring gene ribosomal protein L24 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr17:35814497-35815074 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:35815591-35816092 Neighboring gene MPRA-validated peak2830 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35843239-35843740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35851097-35851882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867118-35867618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867619-35868119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35872759-35873272 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:35901785-35902984 Neighboring gene synergin gamma Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949209-35949710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949711-35950210 Neighboring gene microRNA 378j Neighboring gene DExD-box helicase 52

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Influence of the polymorphism of the DUSP14 gene on the expression of immune-related genes and development of pulmonary tuberculosis. Hijikata M, et al. Genes Immun, 2016 Jun. PMID 26938665
  2. Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Barreiro LB, et al. Proc Natl Acad Sci U S A, 2012 Jan 24. PMID 22233810, Free PMC Article
  3. Overproduction, purification and structure determination of human dual-specificity phosphatase 14. Lountos GT, et al. Acta Crystallogr D Biol Crystallogr, 2009 Oct. PMID 19770498, Free PMC Article
  4. Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver. Wang S, et al. Hepatology, 2018 Apr. PMID 29077210
  5. TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity. Yang CY, et al. Cell Signal, 2016 Jan. PMID 26521044

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bioinformatic studies showed that these two miRNAs target PTEN and DUSP14 tumor suppressor genes. Quantitative Real-time PCR confirmed the overexpression of the miRNAs and downregulation of their targets. Luciferase assay confirmed that the miRNAs target PTEN and DUSP14.
    Title: Evaluation of exosomal miR-9 and miR-155 targeting PTEN and DUSP14 in highly metastatic breast cancer and their effect on low metastatic cells.
  2. Hepatocyte DUSP14 is required for maintaining hepatic metabolic homeostasis and for suppressing inflammation, a novel function that relies on constraining TAK1 hyperactivation
    Title: Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver.
  3. The AA genotype was associated with protection against active TB. Among disease-free individuals, T-helper type-1 related genes, IFNGR2 and STAT1 mRNA levels significantly increased as the number of A alleles of rs1051838 increased.
    Title: Influence of the polymorphism of the DUSP14 gene on the expression of immune-related genes and development of pulmonary tuberculosis.
  4. levels significantly decreased in failing hearts
    Title: Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway.
  5. these findings reveal a novel mechanism by which TRAF2 mediates Lys63-linked ubiquitination of DUSP14, leading to DUSP14 activation in T cells
    Title: TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity.
  6. findings suggest that DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation by dephosphorylating TAK1 at Thr-187
    Title: The dual-specificity phosphatase DUSP14 negatively regulates tumor necrosis factor- and interleukin-1-induced nuclear factor-κB activation by dephosphorylating the protein kinase TAK1.
  7. DUSP14 may be a susceptibility gene for pulmonary tuberculosis.
    Title: Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.
  8. The overproduction, purification and crystal structure at 1.88 A resolution of human dual-specificity phosphatase 14, DUSP14 (MKP6), are reported.
    Title: Overproduction, purification and structure determination of human dual-specificity phosphatase 14.
  9. The binding of Lipomannan to TLR2 triggers MAPK activation, followed by an up-regulation of MKP-1 expression, which in turn may act as a negative regulator of MAPK activation.
    Title: Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages.
  10. Activation of ATM by radiation down-regulates phospho-ERK1/2 and its downstream signaling via increased expression of mitogen-activated protein kinase phosphatase MKP-1.
    Title: Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
EBI GWAS Catalog
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dual specificity protein phosphatase 14
Names
MAP kinase phosphatase 6
MKP-1-like protein tyrosine phosphatase
MKP-6
mitogen-activated protein kinase phosphatase 6
NP_008957.1
XP_005257034.1
XP_011522536.1
XP_047291173.1
XP_054170826.1
XP_054170827.1
XP_054170828.1
XP_054170829.1
XP_054185204.1
XP_054185205.1
XP_054185206.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007026.4 → NP_008957.1  dual specificity protein phosphatase 14

    See identical proteins and their annotated locations for NP_008957.1

    Status: VALIDATED

    Source sequence(s)
    AC243585, AC243654
    Consensus CDS
    CCDS11320.1
    UniProtKB/Swiss-Prot
    O95147
    UniProtKB/TrEMBL
    Q6FI36
    Related
    ENSP00000478595.1, ENST00000617516.5
    Conserved Domains (1) summary
    cd14572
    Location:20 → 169
    DUSP14; dual specificity protein phosphatase 14

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    37488566..37513498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524234.2 → XP_011522536.1  dual specificity protein phosphatase 14 isoform X1

    See identical proteins and their annotated locations for XP_011522536.1

    UniProtKB/Swiss-Prot
    O95147
    UniProtKB/TrEMBL
    Q6FI36
    Conserved Domains (1) summary
    cd14572
    Location:20 → 169
    DUSP14; dual specificity protein phosphatase 14

  2. XM_047435217.1 → XP_047291173.1  dual specificity protein phosphatase 14 isoform X1

    UniProtKB/Swiss-Prot
    O95147
    UniProtKB/TrEMBL
    Q6FI36

  3. XM_005256977.4 → XP_005257034.1  dual specificity protein phosphatase 14 isoform X1

    See identical proteins and their annotated locations for XP_005257034.1

    UniProtKB/Swiss-Prot
    O95147
    UniProtKB/TrEMBL
    Q6FI36
    Related
    ENSP00000484091.1, ENST00000613659.1
    Conserved Domains (1) summary
    cd14572
    Location:20 → 169
    DUSP14; dual specificity protein phosphatase 14

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1725025..1752665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329231.1 → XP_054185206.1  dual specificity protein phosphatase 14 isoform X1

    UniProtKB/Swiss-Prot
    O95147
    UniProtKB/TrEMBL
    Q6FI36

  2. XM_054329230.1 → XP_054185205.1  dual specificity protein phosphatase 14 isoform X1

    UniProtKB/Swiss-Prot
    O95147
    UniProtKB/TrEMBL
    Q6FI36

  3. XM_054329229.1 → XP_054185204.1  dual specificity protein phosphatase 14 isoform X1

    UniProtKB/Swiss-Prot
    O95147
    UniProtKB/TrEMBL
    Q6FI36

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    38472550..38500180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314854.1 → XP_054170829.1  dual specificity protein phosphatase 14 isoform X1

    UniProtKB/Swiss-Prot
    O95147
    UniProtKB/TrEMBL
    Q6FI36

  2. XM_054314853.1 → XP_054170828.1  dual specificity protein phosphatase 14 isoform X1

    UniProtKB/Swiss-Prot
    O95147
    UniProtKB/TrEMBL
    Q6FI36

  3. XM_054314851.1 → XP_054170826.1  dual specificity protein phosphatase 14 isoform X1

    UniProtKB/Swiss-Prot
    O95147
    UniProtKB/TrEMBL
    Q6FI36

  4. XM_054314852.1 → XP_054170827.1  dual specificity protein phosphatase 14 isoform X1

    UniProtKB/Swiss-Prot
    O95147
    UniProtKB/TrEMBL
    Q6FI36
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95147.1 GenPept UniProtKB/Swiss-Prot:O95147

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous