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Pde4c phosphodiesterase 4C, cAMP specific [ Mus musculus (house mouse) ]

Gene ID: 110385, updated on 5-Mar-2024

Summary

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Official Symbol
Pde4cprovided by MGI
Official Full Name
phosphodiesterase 4C, cAMP specificprovided by MGI
Primary source
MGI:MGI:99556
See related
Ensembl:ENSMUSG00000031842 AllianceGenome:MGI:99556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dpde1; dunce; E130301F19Rik
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus and signal transduction. Located in cilium. Is expressed in brain; gonad; metanephros; and submandibular gland. Orthologous to human PDE4C (phosphodiesterase 4C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 28.4), liver adult (RPKM 8.2) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 34.15 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71176485..71203835)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70723835..70751186)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene IQ motif containing N Neighboring gene predicted gene, 34255 Neighboring gene predicted gene 3336 Neighboring gene STARR-positive B cell enhancer ABC_E1370 Neighboring gene STARR-positive B cell enhancer ABC_E190 Neighboring gene RAB3A, member RAS oncogene family Neighboring gene MPV17 mitochondrial membrane protein-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mouse sulfate anion transporter gene Sat1 (Slc26a1): cloning, tissue distribution, gene structure, functional characterization, and transcriptional regulation thyroid hormone. Lee A, et al. DNA Cell Biol, 2003 Jan. PMID 12590734
  2. Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice. Boyd A, et al. Biology (Basel), 2021 Dec 20. PMID 34943270, Free PMC Article
  3. Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice. Aragon IV, et al. Biochem Pharmacol, 2021 Apr. PMID 33609559, Free PMC Article
  4. PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice. McDonough W, et al. FASEB J, 2020 Sep. PMID 32738081, Free PMC Article
  5. Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion. Tian G, et al. J Cell Sci, 2012 Nov 1. PMID 22946044

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC31320

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
3',5'-cyclic-AMP phosphodiesterase 4C
Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
cAMP-specific phosphodiesterase 4C
NP_001297394.1
NP_963901.1
XP_011240550.1
XP_011240560.1
XP_011240561.1
XP_011240562.1
XP_030099101.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310465.1 → NP_001297394.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform 1

    See identical proteins and their annotated locations for NP_001297394.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC162446, AK149514
    Consensus CDS
    CCDS80891.1
    UniProtKB/Swiss-Prot
    Q3UEI1, Q8K0P4
    UniProtKB/TrEMBL
    A0A6I8MX13
    Related
    ENSMUSP00000105722.3, ENSMUST00000110095.3
    Conserved Domains (1) summary
    pfam00233
    Location:388 → 629
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. NM_201607.2 → NP_963901.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform 2

    See identical proteins and their annotated locations for NP_963901.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC162446, AK053713, AK149514
    Consensus CDS
    CCDS22378.1
    UniProtKB/TrEMBL
    A0A6I8MX13
    Related
    ENSMUSP00000034307.8, ENSMUST00000034307.14
    Conserved Domains (1) summary
    pfam00233
    Location:388 → 595
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71176485..71203835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242258.4 → XP_011240560.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X2

    Conserved Domains (2) summary
    pfam00233
    Location:447 → 564
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:213 → 329
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  2. XM_011242248.4 → XP_011240550.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X1

    See identical proteins and their annotated locations for XP_011240550.1

    UniProtKB/TrEMBL
    A0A6I8MX13
    Related
    ENSMUSP00000159363.2, ENSMUST00000239435.2
    Conserved Domains (2) summary
    pfam00233
    Location:447 → 688
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:213 → 329
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  3. XM_011242259.3 → XP_011240561.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X3

    See identical proteins and their annotated locations for XP_011240561.1

    Conserved Domains (1) summary
    pfam00233
    Location:221 → 462
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  4. XM_011242260.4 → XP_011240562.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X3

    See identical proteins and their annotated locations for XP_011240562.1

    Conserved Domains (1) summary
    pfam00233
    Location:221 → 462
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  5. XM_030243241.1 → XP_030099101.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X4

    Conserved Domains (1) summary
    pfam00233
    Location:100 → 341
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UEI1.1 GenPept UniProtKB/Swiss-Prot:Q3UEI1

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