U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

COPS5 COP9 signalosome subunit 5 [ Homo sapiens (human) ]

Gene ID: 10987, updated on 7-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
COPS5provided by HGNC
Official Full Name
COP9 signalosome subunit 5provided by HGNC
Primary source
HGNC:HGNC:2240
See related
Ensembl:ENSG00000121022 MIM:604850; AllianceGenome:HGNC:2240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSN5; JAB1; SGN5; MOV-34
Summary
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 37.3), heart (RPKM 32.6) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See COPS5 in Genome Data Viewer
Location:
8q13.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (67043079..67062133, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (67469560..67488599, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67955314..67974368, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 42 Neighboring gene uncharacterized LOC124902097 Neighboring gene uncharacterized LOC105375885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27495 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:67976583-67976770 Neighboring gene centrosome and spindle pole associated protein 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:68012735-68012945 Neighboring gene RNA, 5S ribosomal pseudogene 268 Neighboring gene uncharacterized LOC124901956

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Regulatory mechanisms and therapeutic potential of JAB1 in neurological development and disorders. Yang Y, et al. Mol Med, 2023 Jun 26. PMID 37365502, Free PMC Article
  2. Jab1/Cops5: a promising target for cancer diagnosis and therapy. Yuan C, et al. Int J Clin Oncol, 2021 Jul. PMID 34019195
  3. JAB1 promotes palmitate-induced insulin resistance via ERK pathway in hepatocytes. Zhao Y, et al. J Physiol Biochem, 2020 Nov. PMID 33051821
  4. The crucial p53-dependent oncogenic role of JAB1 in osteosarcoma in vivo. Samsa WE, et al. Oncogene, 2020 Jun. PMID 32390003, Free PMC Article
  5. Overexpression of JAB1 promotes malignant behavior and predicts poor prognosis in esophageal squamous cell carcinoma. Shen Q, et al. Thorac Cancer, 2020 Apr. PMID 32064781, Free PMC Article

See all (317) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulatory mechanisms and therapeutic potential of JAB1 in neurological development and disorders.
    Title: Regulatory mechanisms and therapeutic potential of JAB1 in neurological development and disorders.
  2. METTL3 upregulates COPS5 expression in osteosarcoma in an m(6)A-related manner to promote osteosarcoma progression.
    Title: METTL3 upregulates COPS5 expression in osteosarcoma in an m(6)A-related manner to promote osteosarcoma progression.
  3. Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic Mouse Model of Alzheimer's Disease.
    Title: Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic Mouse Model of Alzheimer's Disease.
  4. PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of beta-catenin and PD-L1.
    Title: PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1.
  5. PD_BiBIM: Biclustering-based biomarker identification in ESCC microarray data.
    Title: PD_BiBIM: Biclustering-based biomarker identification in ESCC microarray data.
  6. Shikonin-mediated PD-L1 degradation suppresses immune evasion in pancreatic cancer by inhibiting NF-kappaB/STAT3 and NF-kappaB/CSN5 signaling pathways.
    Title: Shikonin-mediated PD-L1 degradation suppresses immune evasion in pancreatic cancer by inhibiting NF-κB/STAT3 and NF-κB/CSN5 signaling pathways.
  7. CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2.
    Title: CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2.
  8. JAB1 promotes palmitate-induced insulin resistance via ERK pathway in hepatocytes.
    Title: JAB1 promotes palmitate-induced insulin resistance via ERK pathway in hepatocytes.
  9. Jab1/Cops5: a promising target for cancer diagnosis and therapy.
    Title: Jab1/Cops5: a promising target for cancer diagnosis and therapy.
  10. alpha5-nAChR contributes to epithelial-mesenchymal transition and metastasis by regulating Jab1/Csn5 signalling in lung cancer.
    Title: α5-nAChR contributes to epithelial-mesenchymal transition and metastasis by regulating Jab1/Csn5 signalling in lung cancer.
Submit: New GeneRIF Correction See all GeneRIFs (130)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with COP9 constitutive photomorphogenic homolog subunit 5 (COPS5; CSN5) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
capsid gag The interaction of HIV-1 CA with human cellular COP9 signalosome subunit 5 protein (COPS5) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC3149

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables deNEDDylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deNEDDylase activity TAS
Traceable Author Statement
more info
  
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables macrophage migration inhibitory factor binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal-dependent deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity TAS
Traceable Author Statement
more info
 PubMed 
enables translation initiation factor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in exosomal secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in post-translational protein modification TAS
Traceable Author Statement
more info
  
involved_in protein deneddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deneddylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deneddylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein neddylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of IRE1-mediated unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein neddylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation TAS
Traceable Author Statement
more info
 PubMed 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COP9 signalosome IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of COP9 signalosome ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic translation initiation factor 3 complex TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
COP9 signalosome complex subunit 5
Names
38 kDa Mov34 homolog
COP9 constitutive photomorphogenic homolog subunit 5
jun activation domain-binding protein 1
signalosome subunit 5
testis secretory sperm-binding protein Li 231m

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006837.3 → NP_006828.2  COP9 signalosome complex subunit 5

    See identical proteins and their annotated locations for NP_006828.2

    Status: REVIEWED

    Source sequence(s)
    BC001187, BI752436
    Consensus CDS
    CCDS6198.1
    UniProtKB/Swiss-Prot
    O15386, Q6AW95, Q86WQ4, Q92905, Q9BQ17
    UniProtKB/TrEMBL
    A0A024R7W9
    Related
    ENSP00000350512.4, ENST00000357849.9
    Conserved Domains (1) summary
    cd08069
    Location:44 → 314
    MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    67043079..67062133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    67469560..67488599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92905.4 GenPept UniProtKB/Swiss-Prot:Q92905

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous