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GPR83 G protein-coupled receptor 83 [ Homo sapiens (human) ]

Gene ID: 10888, updated on 11-Apr-2024

Summary

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Official Symbol
GPR83provided by HGNC
Official Full Name
G protein-coupled receptor 83provided by HGNC
Primary source
HGNC:HGNC:4523
See related
Ensembl:ENSG00000123901 MIM:605569; AllianceGenome:HGNC:4523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIR; GPR72
Summary
Predicted to enable neuropeptide receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within response to glucocorticoid. Located in cilium. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 1.9), thyroid (RPKM 1.3) and 4 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11q21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (94377316..94401419, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (94384353..94408454, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94110482..94134585, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369435 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:93970861-93972060 Neighboring gene NANOG hESC enhancer GRCh37_chr11:93995336-93995837 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:94011033-94012232 Neighboring gene IZUMO1 receptor, JUNO Neighboring gene NANOG hESC enhancer GRCh37_chr11:94083994-94084545 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:94113450-94113647 Neighboring gene MRE11 homolog, double strand break repair nuclease Neighboring gene microRNA 548l Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5403 Neighboring gene ankyrin repeat domain 49

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells. Hansen W, et al. Genes Immun, 2010 Jun. PMID 20200545
  2. G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. Hansen W, et al. J Immunol, 2006 Jul 1. PMID 16785516
  3. FAM237A, rather than peptide PEN and proCCK56-63, binds to and activates the orphan receptor GPR83. Li HZ, et al. FEBS J, 2023 Jul. PMID 36853120
  4. A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands. Sallee NA, et al. SLAS Discov, 2020 Oct. PMID 32713278
  5. Cloning and chromosomal mapping of the mouse and human genes encoding the orphan glucocorticoid-induced receptor (GPR83). De Moerlooze L, et al. Cytogenet Cell Genet, 2000. PMID 11060465

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands.
    Title: A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands.
  2. results suggest that the 20 additional aminoacids within GPR83 isoform-4 are involved in Treg induction during inflammatory immune responses
    Title: Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells.
  3. GPR83 is 2- to 7-fold up-regulated in all indvidual human CD4+CD25+ T regulatory cell populations analyzed and is directly linked to Foxp3 expression.
    Title: G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in feeding behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in non-motile cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 83
Names
G-protein coupled receptor 72
glucocorticoid induced receptor
probable G-protein coupled receptor 83

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330345.2 → NP_001317274.1  G-protein coupled receptor 83 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AP000765
    Consensus CDS
    CCDS81616.1
    UniProtKB/TrEMBL
    Q6NWR3
    Related
    ENSP00000441550.1, ENST00000539203.2
    Conserved Domains (1) summary
    pfam00001
    Location:88 → 303
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. NM_016540.4 → NP_057624.3  G-protein coupled receptor 83 isoform 1 precursor

    See identical proteins and their annotated locations for NP_057624.3

    Status: VALIDATED

    Source sequence(s)
    AB040973, AI914177, AK315161, AP000765, DA317535
    Consensus CDS
    CCDS8297.1
    UniProtKB/Swiss-Prot
    B0M0K5, F5GZ43, Q6NWR4, Q9NYM4, Q9P1Y8
    UniProtKB/TrEMBL
    Q6NWR3
    Related
    ENSP00000243673.2, ENST00000243673.7
    Conserved Domains (1) summary
    cd15389
    Location:72 → 356
    7tmA_GPR83; G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    94377316..94401419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    94384353..94408454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NYM4.2 GenPept UniProtKB/Swiss-Prot:Q9NYM4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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