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Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta [ Mus musculus (house mouse) ]

Gene ID: 108083, updated on 11-Apr-2024

Summary

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Official Symbol
Pip4k2bprovided by MGI
Official Full Name
phosphatidylinositol-5-phosphate 4-kinase, type II, betaprovided by MGI
Primary source
MGI:MGI:1934234
See related
Ensembl:ENSMUSG00000018547 AllianceGenome:MGI:1934234
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
c11; Pip5k2b; PI5P4Kbeta
Summary
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity; protein homodimerization activity; and purine ribonucleoside triphosphate binding activity. Involved in autophagosome-lysosome fusion and regulation of autophagy. Acts upstream of or within phosphatidylinositol metabolic process. Predicted to be located in autophagosome; nucleoplasm; and plasma membrane. Is expressed in head bone; nervous system; and sensory organ. Orthologous to human PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase type 2 beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 28.7), whole brain E14.5 (RPKM 24.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 61.07 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97605983..97635530, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97715157..97744704, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7051 Neighboring gene STARR-positive B cell enhancer ABC_E1430 Neighboring gene nuclear encoded tRNA asparagine 8 (anticodon GTT) Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97606458-97606567 Neighboring gene microRNA 8102 Neighboring gene CWC25 spliceosome-associated protein Neighboring gene STARR-positive B cell enhancer ABC_E2368

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Lamia KA, et al. Mol Cell Biol, 2004 Jun. PMID 15143198, Free PMC Article
  2. Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Lundquist MR, et al. Mol Cell, 2018 May 3. PMID 29727621, Free PMC Article
  3. PIP4K and the role of nuclear phosphoinositides in tumour suppression. Fiume R, et al. Biochim Biophys Acta, 2015 Jun. PMID 25728392
  4. A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. Castellino AM, et al. J Biol Chem, 1997 Feb 28. PMID 9038203
  5. Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain. Noch EK, et al. J Comp Neurol, 2021 Feb. PMID 32449185, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.
    Title: Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.
  2. Suppression of PIP4K expression selectively prevents tumor cell growth in vitro and prevents tumor development in mice that have lost the tumor suppressor p53. (Review)
    Title: PIP4K and the role of nuclear phosphoinositides in tumour suppression.
  3. located within a 185-kb contig surrounding a transgene on chromosome 11
    Title: Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome-lysosome fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphatidylinositol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Names
1-phosphatidylinositol 5-phosphate 4-kinase 2-beta
PI(5)P 4-kinase type II beta
PIP4KII-beta
diphosphoinositide kinase 2-beta
phosphatidylinositol-4-phosphate 5-kinase, type II, beta
NP_473392.1
XP_030101326.1
XP_036012113.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054051.1 → NP_473392.1  phosphatidylinositol 5-phosphate 4-kinase type-2 beta

    See identical proteins and their annotated locations for NP_473392.1

    Status: PROVISIONAL

    Source sequence(s)
    BC047282
    Consensus CDS
    CCDS25329.1
    UniProtKB/Swiss-Prot
    Q80XI4, Q8VHB2
    UniProtKB/TrEMBL
    Q3UJ95
    Related
    ENSMUSP00000018691.9, ENSMUST00000018691.9
    Conserved Domains (1) summary
    cd17310
    Location:30 → 413
    PIPKc_PIP5K2B; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP5K2B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97605983..97635530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156220.1 → XP_036012113.1  phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1

    Conserved Domains (1) summary
    cl28923
    Location:1 → 349
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

  2. XM_030245466.2 → XP_030101326.1  phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1

    Conserved Domains (1) summary
    cl28923
    Location:1 → 349
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XI4.1 GenPept UniProtKB/Swiss-Prot:Q80XI4

Gene LinkOut

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