Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Celsr3provided by MGI
Official Full Name: cadherin, EGF LAG seven-pass G-type receptor 3provided by MGI
Primary source: MGI:MGI:1858236
See related: Ensembl:ENSMUSG00000023473 AllianceGenome:MGI:1858236
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fmi1; Adgrc3; flamingo; mKIAA0812
Summary: Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in dopaminergic neuron axon guidance; planar cell polarity pathway involved in axon guidance; and serotonergic neuron axon guidance. Acts upstream of or within several processes, including cilium assembly; generation of neurons; and regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; embryo ectoderm; epiblast; peripheral nervous system; and retina. Orthologous to human CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 20.1), CNS E18 (RPKM 16.6) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.63 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108703244..108730168)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108826023..108852969)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Celsr3 Inactivation in the Brainstem Impairs Rubrospinal Tract Development and Mouse Behaviors in Motor Coordination and Mechanic-Induced Response.
Title: Celsr3 Inactivation in the Brainstem Impairs Rubrospinal Tract Development and Mouse Behaviors in Motor Coordination and Mechanic-Induced Response.
The Celsr3-Kif2a axis directs neuronal migration in the postnatal brain.
Title: The Celsr3-Kif2a axis directs neuronal migration in the postnatal brain.
Celsr3 is dispensable for the patterning of central dorsal root ganglion projections, but it regulates for the fine mapping of sensory fibers in the gray matter, which is important for somatosensory processing.
Title: The role of Celsr3 in the development of central somatosensory projections from dorsal root ganglia.
The Celsr3-mediated signaling pathway responds to the inhibitory function of Wnt5a in glutamatergic synapse formation. We also revealed the opposing roles of Wnt-regulated planar cell polarity components, Celsr3 and Vangl2, in glutamatergic synapse formation.
Title: Evidence for opposing roles of Celsr3 and Vangl2 in glutamatergic synapse formation.
Results suggest that Celsr3 and Fzd3 orchestrate the formation of a scaffold of pioneer neurons and their axons during embryogenesis. This scaffold extends from prethalamus to ventral telencephalon and subcortex, and steers reciprocal corticothalamic fibers.
Title: Celsr3 and Fzd3 Organize a Pioneer Neuron Scaffold to Steer Growing Thalamocortical Axons.
Celsr3 and Fzd3 enable immature neurons to respond to Wnt7, upregulate Jag1 and thereby facilitate feedback signals that tune the timing of neural progenitor cell fate decisions via Notch activation.
Title: Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling.
Our results provide evidence that the Celsr3-Fzd3 pathway interacts with EphA-ephrinA reverse signaling to guide motor axons in the hindlimb.
Title: Celsr3 is required in motor neurons to steer their axons in the hindlimb.
The essential role of Celsr3 in globus pallidus development.
Title: Regulation of the protocadherin Celsr3 gene and its role in globus pallidus development and connectivity.
The first signal, controlled by cadherin, EGF-like, laminin G-like, seven-pass, G-type receptor (Celsr) 2, Celsr3, Frizzled3 (Fzd3) and Van Gogh like2 (Vangl2) organizes multicilia in individual cells (single-cell polarity)
Title: A dual role for planar cell polarity genes in ciliated cells.
Celsr2-3 and Fzd3 regulate axonal navigation in the forebrain by using mechanisms different from classical epithelial core planar cell polarity, and require interacting partners other than Vangl1-2 that remain to be identified.
Title: Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Celsr3 (e-PCR), detects polymorphism
- UniSTS:164879

Celsr3 (e-PCR), detects polymorphism
- UniSTS:532450

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway, planar cell polarity pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dopaminergic neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motor neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein localization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonergic neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cadherin EGF LAG seven-pass G-type receptor 3

Names: cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359572.1 → NP_001346501.1 cadherin EGF LAG seven-pass G-type receptor 3 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC168054

Consensus CDS

CCDS90664.1

UniProtKB/TrEMBL

A0A076N9U7, A0A1L1SUG9

Related

ENSMUSP00000150759.2, ENSMUST00000213524.3

Conserved Domains (10) summary

smart00303
Location:2474 → 2527

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:646 → 743

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2117 → 2181

HormR; Domain present in hormone receptors

cd00054
Location:1717 → 1748

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2067 → 2105

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1508 → 1691

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1994 → 2033

Laminin_EGF; Laminin EGF domain

pfam16489
Location:2200 → 2448

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cd14964
Location:2537 → 2561

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:2534 → 2787

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001359573.1 → NP_001346502.1 cadherin EGF LAG seven-pass G-type receptor 3 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC168054

UniProtKB/TrEMBL

A0A076N9U7

Conserved Domains (10) summary

smart00303
Location:2474 → 2527

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:646 → 743

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2117 → 2181

HormR; Domain present in hormone receptors

cd00054
Location:1717 → 1748

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2067 → 2105

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1508 → 1691

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1994 → 2033

Laminin_EGF; Laminin EGF domain

pfam16489
Location:2200 → 2448

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cd14964
Location:2537 → 2561

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:2534 → 2786

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_080437.3 → NP_536685.2 cadherin EGF LAG seven-pass G-type receptor 3 isoform 3 precursor

See identical proteins and their annotated locations for NP_536685.2

Status: VALIDATED

Source sequence(s)

AC168054, AF427498, AI854184, CA328665

UniProtKB/Swiss-Prot

E9QLD7, Q91ZI0, Q9ESD0

UniProtKB/TrEMBL

A0A076N9U7

Related

ENSMUSP00000024238.6, ENSMUST00000024238.11

Conserved Domains (9) summary

smart00303
Location:2467 → 2520

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:646 → 743

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2115 → 2174

HormR; Domain present in hormone receptors

cd00054
Location:1715 → 1746

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2065 → 2103

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1506 → 1689

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00002
Location:2527 → 2758

7tm_2; 7 transmembrane receptor (Secretin family)

pfam00053
Location:1992 → 2031

Laminin_EGF; Laminin EGF domain

pfam16489
Location:2194 → 2439

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

108703244..108730168

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511622.3 → XP_006511685.1 cadherin EGF LAG seven-pass G-type receptor 3 isoform X1

UniProtKB/TrEMBL

A0A076N9U7

Conserved Domains (10) summary

smart00303
Location:2469 → 2522

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:646 → 743

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2117 → 2176

HormR; Domain present in hormone receptors

cd00054
Location:1717 → 1748

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2067 → 2105

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1508 → 1691

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd14964
Location:2531 → 2556

7tm_GPCRs; TM helix 1 [structural motif]

pfam00053
Location:1994 → 2033

Laminin_EGF; Laminin EGF domain

pfam16489
Location:2195 → 2443

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl28897
Location:2529 → 2782

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006511623.3 → XP_006511686.1 cadherin EGF LAG seven-pass G-type receptor 3 isoform X2

UniProtKB/TrEMBL

A0A076N9U7

Conserved Domains (10) summary

smart00303
Location:2469 → 2522

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:646 → 743

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2117 → 2176

HormR; Domain present in hormone receptors

cd00054
Location:1717 → 1748

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2067 → 2105

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1508 → 1691

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd14964
Location:2531 → 2556

7tm_GPCRs; TM helix 1 [structural motif]

pfam00053
Location:1994 → 2033

Laminin_EGF; Laminin EGF domain

pfam16489
Location:2195 → 2443

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl28897
Location:2529 → 2781

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006511625.4 → XP_006511688.1 cadherin EGF LAG seven-pass G-type receptor 3 isoform X3

UniProtKB/TrEMBL

A0A076N9U7

Conserved Domains (10) summary

smart00303
Location:2474 → 2527

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:646 → 743

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:2117 → 2181

HormR; Domain present in hormone receptors

cd00054
Location:1717 → 1748

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2067 → 2105

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1508 → 1691

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd14964
Location:2536 → 2561

7tm_GPCRs; TM helix 1 [structural motif]

pfam00053
Location:1994 → 2033

Laminin_EGF; Laminin EGF domain

pfam16489
Location:2200 → 2448

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl28897
Location:2534 → 2724

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006511626.3 → XP_006511689.1 cadherin EGF LAG seven-pass G-type receptor 3 isoform X4

Conserved Domains (6) summary

cd11304
Location:646 → 743

Cadherin_repeat; Cadherin tandem repeat domain

PHA03307
Location:9 → 276

PHA03307; transcriptional regulator ICP4; Provisional

cd00054
Location:1717 → 1748

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:2030 → 2053

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1508 → 1691

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1994 → 2033

Laminin_EGF; Laminin EGF domain