Cth cystathionine gamma lyase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cthprovided by MGI
Official Full Name: cystathionine gamma lyaseprovided by MGI
Primary source: MGI:MGI:1339968
See related: Ensembl:ENSMUSG00000028179 AllianceGenome:MGI:1339968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CGL; CSE; Cys3; 0610010I13Rik
Summary: Enables L-cystine L-cysteine-lyase (deaminating) and cystathionine gamma-lyase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and protein sulfhydration. Acts upstream of or within cellular response to leukemia inhibitory factor and negative regulation of apoptotic signaling pathway. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; cranium; ear; and genitourinary system. Used to study cystathioninuria. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 166.5), liver E18 (RPKM 68.3) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H4; 3 81.55 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (157599885..157630718, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (157894248..157925081, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Weakening of M1 macrophage and bone resorption in periodontitis cystathionine gamma-lyase-deficient mice.
Title: Weakening of M1 macrophage and bone resorption in periodontitis cystathionine γ-lyase-deficient mice.
Disrupted Binding of Cystathionine gamma-Lyase to p53 Promotes Endothelial Senescence.
Title: Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence.
Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE[-/-] mice corpus cavernosum microcirculation.
Title: Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE(-/-) mice corpus cavernosum microcirculation.
Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation.
Title: Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation.
Cystine/Glutamate Xc[-] Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis.
Title: Cystine/Glutamate Xc(-) Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis.
Cystathionine gamma-lyase (Cth) induces efferocytosis in macrophages via ERK1/2 to modulate intestinal barrier repair.
Title: Cystathionine gamma-lyase (Cth) induces efferocytosis in macrophages via ERK1/2 to modulate intestinal barrier repair.
Hepatocellular cystathionine gamma lyase/hydrogen sulfide attenuates nonalcoholic fatty liver disease by activating farnesoid X receptor.
Title: Hepatocellular cystathionine γ lyase/hydrogen sulfide attenuates nonalcoholic fatty liver disease by activating farnesoid X receptor.
The DR1CSE/H2S system inhibits renal fibrosis by downregulating the ERK1/2 signaling pathway in diabetic mice.
Title: The DR1‑CSE/H(2)S system inhibits renal fibrosis by downregulating the ERK1/2 signaling pathway in diabetic mice.
High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways.
Title: High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways.
DR1 activation promotes vascular smooth muscle cell apoptosis via up-regulation of CSE/H2 S pathway in diabetic mice.
Title: DR1 activation promotes vascular smooth muscle cell apoptosis via up-regulation of CSE/H(2) S pathway in diabetic mice.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-cysteine desulfhydrase activity	IEA Inferred from Electronic Annotation more info
enables L-cystine L-cysteine-lyase (deaminating)	IDA Inferred from Direct Assay more info	PubMed
enables L-cystine L-cysteine-lyase (deaminating)	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-cystine L-cysteine-lyase (deaminating)	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cystathionine beta-lyase activity	ISO Inferred from Sequence Orthology more info
enables cystathionine gamma-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cystathionine gamma-lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables cystathionine gamma-lyase activity	ISO Inferred from Sequence Orthology more info
enables homocysteine desulfhydrase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cysteine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cysteine biosynthetic process via cystathionine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cysteine biosynthetic process via cystathionine	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in homocysteine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hydrogen sulfide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of aortic smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein sulfhydration	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sulfhydration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein sulfhydration	ISO Inferred from Sequence Orthology more info
involved_in protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	ISO Inferred from Sequence Orthology more info
involved_in transsulfuration	IBA Inferred from Biological aspect of Ancestor more info
involved_in transsulfuration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cystathionine gamma-lyase

Names: cystathionase (cystathionine gamma-lyase); cysteine desulfhydrase; cysteine-protein sulfhydrase; homocysteine desulfhydrase

NP_666065.1

EC 4.4.1.1

EC 4.4.1.2

XP_006500878.1

EC 4.4.1.1

EC 4.4.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145953.2 → NP_666065.1 cystathionine gamma-lyase

See identical proteins and their annotated locations for NP_666065.1

Status: VALIDATED

Source sequence(s)

AY083352

Consensus CDS

CCDS51101.1

UniProtKB/Swiss-Prot

Q6H324, Q8VCN5

Related

ENSMUSP00000113672.2, ENSMUST00000118539.2

Conserved Domains (2) summary

PRK08776
Location:16 → 396

PRK08776; cystathionine gamma-synthase; Provisional

pfam01053
Location:18 → 394

Cys_Met_Meta_PP; Cys/Met metabolizm PLP-dependent enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

157599885..157630718 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500815.4 → XP_006500878.1 cystathionine gamma-lyase isoform X1

Conserved Domains (1) summary

cl18945
Location:56 → 298

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...