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Haao 3-hydroxyanthranilate 3,4-dioxygenase [ Mus musculus (house mouse) ]

Gene ID: 107766, updated on 11-Apr-2024

Summary

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Official Symbol
Haaoprovided by MGI
Official Full Name
3-hydroxyanthranilate 3,4-dioxygenaseprovided by MGI
Primary source
MGI:MGI:1349444
See related
Ensembl:ENSMUSG00000000673 AllianceGenome:MGI:1349444
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3HAO; 3-HAO; 3-HAOxase; 0610007K21Rik; 0610012J07Rik
Summary
Enables 3-hydroxyanthranilate 3,4-dioxygenase activity. Predicted to be involved in several processes, including pyridine-containing compound biosynthetic process; response to cadmium ion; and response to zinc ion. Predicted to act upstream of or within pyridine nucleotide biosynthetic process. Predicted to be located in cytosol and mitochondrial membrane. Predicted to be active in cytoplasm. Is expressed in ductus deferens; epididymis; esophagus; metanephros; and testis. Orthologous to human HAAO (3-hydroxyanthranilate 3,4-dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 126.1), kidney adult (RPKM 31.2) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Haao in Genome Data Viewer
Location:
17 E4; 17 54.85 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (84138777..84157589, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (83831348..83848981, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene metastasis associated 3 Neighboring gene predicted gene, 46597 Neighboring gene STARR-seq mESC enhancer starr_43408 Neighboring gene predicted gene, 41637 Neighboring gene STARR-positive B cell enhancer ABC_E1202 Neighboring gene RIKEN cDNA C430042M11 gene Neighboring gene chaperonin containing Tcp1, subunit 7 (eta) pseudogene Neighboring gene nuclear encoded tRNA isoleucine 17 (anticodon TAT)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NAD deficiency due to environmental factors or gene-environment interactions causes congenital malformations and miscarriage in mice. Cuny H, et al. Proc Natl Acad Sci U S A, 2020 Feb 18. PMID 32015132, Free PMC Article
  2. High levels of quinolinic acid in brain of epilepsy-prone E1 mice. Nakano K, et al. Brain Res, 1993 Aug 13. PMID 8374778
  3. Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation. Parrott JM, et al. Transl Psychiatry, 2016 Oct 18. PMID 27754481, Free PMC Article
  4. Increased expression of 3-hydroxyanthranilate 3,4-dioxygenase gene in brain of epilepsy-prone El mice. Nakagawa Y, et al. Brain Res Mol Brain Res, 1998 Jul 15. PMID 9685612
  5. Differential expression of the astrocytic enzymes 3-hydroxyanthranilic acid oxygenase, kynurenine aminotransferase and glutamine synthetase in seizure-prone and non-epileptic mice. Eastman CL, et al. Epilepsy Res, 1994 Jul. PMID 7805640

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-hydroxyanthranilate 3,4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxyanthranilate 3,4-dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-hydroxyanthranilate 3,4-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxygen binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NAD biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pyridine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in quinolinate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in quinolinate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in quinolinate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cadmium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in response to zinc ion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
3-hydroxyanthranilate 3,4-dioxygenase
Names
3-hydroxyanthranilate oxygenase
3-hydroxyanthranilic acid dioxygenase
HAD
NP_079601.1
XP_006523526.1
XP_006523528.1
XP_030105301.1
XP_030105302.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025325.2 → NP_079601.1  3-hydroxyanthranilate 3,4-dioxygenase

    See identical proteins and their annotated locations for NP_079601.1

    Status: PROVISIONAL

    Source sequence(s)
    BC094021
    Consensus CDS
    CCDS37709.1
    UniProtKB/Swiss-Prot
    Q52L88, Q78JT3
    Related
    ENSMUSP00000000687.8, ENSMUST00000000687.9
    Conserved Domains (2) summary
    cd06123
    Location:10 → 159
    cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain
    cl40423
    Location:209 → 260
    cupin_RmlC-like; RmlC-like cupin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    84138777..84157589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523463.5 → XP_006523526.1  3-hydroxyanthranilate 3,4-dioxygenase isoform X1

    See identical proteins and their annotated locations for XP_006523526.1

    UniProtKB/Swiss-Prot
    Q52L88, Q78JT3
    Conserved Domains (2) summary
    cd06123
    Location:10 → 159
    cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain
    cl40423
    Location:209 → 260
    cupin_RmlC-like; RmlC-like cupin superfamily

  2. XM_030249442.2 → XP_030105302.1  3-hydroxyanthranilate 3,4-dioxygenase isoform X3

    Conserved Domains (2) summary
    cd06123
    Location:1 → 98
    cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain
    cl40423
    Location:148 → 199
    cupin_RmlC-like; RmlC-like cupin superfamily

  3. XM_006523465.5 → XP_006523528.1  3-hydroxyanthranilate 3,4-dioxygenase isoform X2

    Conserved Domains (2) summary
    cd06123
    Location:1 → 125
    cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain
    cl40423
    Location:175 → 226
    cupin_RmlC-like; RmlC-like cupin superfamily

  4. XM_030249441.2 → XP_030105301.1  3-hydroxyanthranilate 3,4-dioxygenase isoform X1

    UniProtKB/Swiss-Prot
    Q52L88, Q78JT3
    Conserved Domains (2) summary
    cd06123
    Location:10 → 159
    cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain
    cl40423
    Location:209 → 260
    cupin_RmlC-like; RmlC-like cupin superfamily

RNA

  1. XR_385257.5 RNA Sequence

  2. XR_004939459.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q78JT3.1 GenPept UniProtKB/Swiss-Prot:Q78JT3

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