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Asmt acetylserotonin O-methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 107626, updated on 21-Apr-2024

Summary

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Official Symbol
Asmtprovided by MGI
Official Full Name
acetylserotonin O-methyltransferaseprovided by MGI
Primary source
MGI:MGI:96090
See related
Ensembl:ENSMUSG00000093806 AllianceGenome:MGI:96090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hiomt
Summary
This gene belongs to the methyltransferase superfamily and is located in the pseudoautosomal region (PAR) of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin and is abundant in the pineal gland. Two amino acid substitutions (R78G and R242C) are present in the encoded protein derived from the reference strain, C57BL/6J, and this protein shows low enzyme activity relative to the protein derived from other strains. [provided by RefSeq, May 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
X F5; X
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (169106379..169111787)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (170672644..170678054)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene neuroligin 4-like Neighboring gene RIKEN cDNA 2510022D24 gene Neighboring gene A-kinase anchoring protein 17A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Trent S, et al. Psychoneuroendocrinology, 2013 Aug. PMID 23276394, Free PMC Article
  2. Preliminary investigations of melatonin and 5-methoxy-tryptophol synthesis in the pineal, retina, and harderian gland of the mole rat and in the pineal of the mouse "eyeless". Balemans MG, et al. J Neural Transm, 1980. PMID 7463037
  3. Day/night serotonin levels in the pineal gland of male BALB/c mice with melatonin deficiency. Vollrath L, et al. Acta Endocrinol (Copenh), 1988 Jan. PMID 3381630
  4. Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin-proficient C57BL/6J congenic mice. Zhang C, et al. J Pineal Res, 2021 Sep. PMID 34085306
  5. A congenic line of the C57BL/6J mouse strain that is proficient in melatonin synthesis. Zhang Z, et al. J Pineal Res, 2018 Oct. PMID 29768727, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ASMT determines gut microbiota and increases neurobehavioral adaptability to exercise in female mice.
    Title: ASMT determines gut microbiota and increases neurobehavioral adaptability to exercise in female mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables S-adenosylmethionine-dependent methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylserotonin O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylserotonin O-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylserotonin O-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acetylserotonin O-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of male gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in melatonin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within melatonin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within melatonin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in melatonin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of male gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
acetylserotonin O-methyltransferase
Names
hydroxyindole O-methyltransfease
NP_001295417.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199212.1 → NP_001186141.1  acetylserotonin O-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001186141.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is based on a transcript from the C3H/HeJ strain and encodes an isoform (1) with high enzyme activity.
    Source sequence(s)
    AB512671
    UniProtKB/Swiss-Prot
    D3KU65, D3KU66, D3KU67
    Conserved Domains (2) summary
    pfam00891
    Location:111 → 338
    Methyltransf_2; O-methyltransferase
    cl06920
    Location:18 → 105
    Dimerisation2; Dimerization domain

  2. NM_001308488.2 → NP_001295417.1  acetylserotonin O-methyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001295417.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is based on a transcript from the reference strain and includes seven nucleotide substitutions in the coding sequence compared to variant 1. Two of these nucleotide substitutions result in amino acid substitutions (R78G and R242C) in the encoded isoform (2), which shows low enzyme activity.
    Source sequence(s)
    AEKQ02189142, MG954260
    Consensus CDS
    CCDS85832.1
    UniProtKB/Swiss-Prot
    D3KU67
    UniProtKB/TrEMBL
    A0A0R4J285
    Related
    ENSMUSP00000137135.2, ENSMUST00000178693.5
    Conserved Domains (2) summary
    pfam00891
    Location:111 → 338
    Methyltransf_2; O-methyltransferase
    cl06920
    Location:18 → 105
    Dimerisation2; Dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    169106379..169111787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_037594.1: Suppressed sequence

    Description
    NR_037594.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3KU66.1 GenPept UniProtKB/Swiss-Prot:D3KU66
D3KU67.1 GenPept UniProtKB/Swiss-Prot:D3KU67

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
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