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SH2B2 SH2B adaptor protein 2 [ Homo sapiens (human) ]

Gene ID: 10603, updated on 4-Jan-2025

Summary

Official Symbol
SH2B2provided by HGNC
Official Full Name
SH2B adaptor protein 2provided by HGNC
Primary source
HGNC:HGNC:17381
See related
Ensembl:ENSG00000160999 MIM:605300; AllianceGenome:HGNC:17381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APS
Summary
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]
Expression
Broad expression in lymph node (RPKM 2.3), spleen (RPKM 2.2) and 22 other tissues See more
Orthologs
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Genomic context

See SH2B2 in Genome Data Viewer
Location:
7q22.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102285141..102321711)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103602545..103639107)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (101928432..101962178)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cut like homeobox 1 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:101841732-101842931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26420 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18498 Neighboring gene uncharacterized LOC124901711 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:101911196-101911353 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101917405-101918238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101922504-101923122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101923123-101923741 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:101927516-101927700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18499 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26423 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:101937369-101938122 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:101949043-101949828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26425 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:101951399-101952183 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101957283-101957934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101957935-101958585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101959159-101959659 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101960288-101961000 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101962426-101963137 Neighboring gene uncharacterized LOC107986717 Neighboring gene microRNA 4285 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of SH2B adaptor protein 2 (SH2B2) in human B cells PubMed
Nef nef Genome-wide shRNA screening identifies SH2B2, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in B cell receptor signaling pathway PubMed 
involved_in B-1 B cell homeostasis  
involved_in actin cytoskeleton organization  
involved_in antigen receptor-mediated signaling pathway  
involved_in brown fat cell differentiation  
involved_in cytokine-mediated signaling pathway  
involved_in insulin receptor signaling pathway  
involved_in intracellular signal transduction  
involved_in nervous system development  
involved_in regulation of Ras protein signal transduction  
involved_in regulation of metabolic process  
Component Evidence Code Pubs
located_in actin filament  
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in ruffle  
located_in stress fiber  

General protein information

Preferred Names
SH2B adapter protein 2
Names
SH2 and PH domain-containing adapter protein APS
adapter protein with pleckstrin homology and Src homology 2 domains

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033220.1 RefSeqGene

    Range
    5028..41598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001359228.2NP_001346157.1  SH2B adapter protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB000520, AC091390, BI261466, CB053166, HY020205
    Consensus CDS
    CCDS78264.2
    UniProtKB/Swiss-Prot
    A0A0A0MTI2, A6ND74, O14492
    Related
    ENSP00000401883.3, ENST00000444095.3
    Conserved Domains (3) summary
    cd10411
    Location:409504
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:193308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:2278
    Phe_ZIP; Phenylalanine zipper
  2. NM_001359229.2NP_001346158.1  SH2B adapter protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB000520, AC091390, BI261466, CB053166
    Consensus CDS
    CCDS78264.2
    UniProtKB/Swiss-Prot
    A0A0A0MTI2, A6ND74, O14492
    Conserved Domains (3) summary
    cd10411
    Location:409504
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:193308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:2278
    Phe_ZIP; Phenylalanine zipper
  3. NM_001359230.2NP_001346159.1  SH2B adapter protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AA292710, AB000520, AC091390, BI261466, CB053166, HY020205
    Conserved Domains (3) summary
    cd10411
    Location:408503
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:193308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:2278
    Phe_ZIP; Phenylalanine zipper
  4. NM_001359231.2NP_001346160.1  SH2B adapter protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AA292710, AB000520, AC091390, BI261466, CB053166
    Conserved Domains (3) summary
    cd10411
    Location:408503
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:193308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:2278
    Phe_ZIP; Phenylalanine zipper
  5. NM_001393990.3NP_001380919.2  SH2B adapter protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC091390
    Conserved Domains (3) summary
    cd10411
    Location:408503
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:193308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:2278
    Phe_ZIP; Phenylalanine zipper
  6. NM_001393991.3NP_001380920.2  SH2B adapter protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC091390
    Consensus CDS
    CCDS78264.2
    UniProtKB/Swiss-Prot
    A0A0A0MTI2, A6ND74, O14492
    Conserved Domains (3) summary
    cd10411
    Location:409504
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:193308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:2278
    Phe_ZIP; Phenylalanine zipper
  7. NM_001393992.3NP_001380921.2  SH2B adapter protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC091390
    Conserved Domains (3) summary
    cd10411
    Location:408503
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:193308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:2278
    Phe_ZIP; Phenylalanine zipper
  8. NM_001393993.1NP_001380922.1  SH2B adapter protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC091390
    Consensus CDS
    CCDS78264.2
    UniProtKB/Swiss-Prot
    A0A0A0MTI2, A6ND74, O14492
    Conserved Domains (3) summary
    cd10411
    Location:409504
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:193308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:2278
    Phe_ZIP; Phenylalanine zipper
  9. NM_001393994.1NP_001380923.1  SH2B adapter protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC091390
    Consensus CDS
    CCDS78264.2
    UniProtKB/Swiss-Prot
    A0A0A0MTI2, A6ND74, O14492
    Conserved Domains (3) summary
    cd10411
    Location:409504
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:193308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:2278
    Phe_ZIP; Phenylalanine zipper
  10. NM_001393995.1NP_001380924.1  SH2B adapter protein 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC091390
    Conserved Domains (2) summary
    cd10411
    Location:191286
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cl17171
    Location:2690
    PH-like; Pleckstrin homology-like domain
  11. NM_001394426.1NP_001381355.1  SH2B adapter protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC091390
    Consensus CDS
    CCDS78264.2
    UniProtKB/Swiss-Prot
    A0A0A0MTI2, A6ND74, O14492
    Related
    ENSP00000440273.4, ENST00000536178.3
    Conserved Domains (3) summary
    cd10411
    Location:409504
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:193308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:2278
    Phe_ZIP; Phenylalanine zipper

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    102285141..102321711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419780.1XP_047275736.1  SH2B adapter protein 2 isoform X2

  2. XM_047419779.1XP_047275735.1  SH2B adapter protein 2 isoform X1

  3. XM_047419781.1XP_047275737.1  SH2B adapter protein 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    103602545..103639107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357095.1XP_054213070.1  SH2B adapter protein 2 isoform X2

  2. XM_054357094.1XP_054213069.1  SH2B adapter protein 2 isoform X1

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