PRDX4 peroxiredoxin 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRDX4provided by HGNC
Official Full Name: peroxiredoxin 4provided by HGNC
Primary source: HGNC:HGNC:17169
See related: Ensembl:ENSG00000123131 MIM:300927; AllianceGenome:HGNC:17169
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRX-4; AOE372; AOE37-2; HEL-S-97n
Summary: The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in pancreas (RPKM 49.0), liver (RPKM 22.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xp22.11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (23667493..23686397)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (23251060..23269952)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (23685610..23704514)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The combination of the low immunohistochemical expression of peroxiredoxin 4 and perilipin 2 predicts longer survival in pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly playing a main role.
Title: The combination of the low immunohistochemical expression of peroxiredoxin 4 and perilipin 2 predicts longer survival in pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly playing a main role.
Peroxiredoxin 4 regulates tumor-cell-like characteristics of fibroblast-like synoviocytes in rheumatoid arthritis through PI3k/Akt signaling pathway.
Title: Peroxiredoxin 4 regulates tumor-cell-like characteristics of fibroblast-like synoviocytes in rheumatoid arthritis through PI3k/Akt signaling pathway.
Association of glutamate cystein ligase (GCL) activity Peroxiredoxin 4 (prxR4) and apelin levels in women with preeclampsia.
Title: Association of glutamate cystein ligase (GCL) activity Peroxiredoxin 4 (prxR4) and apelin levels in women with preeclampsia.
Overexpression of PRDX4 Modulates Tumor Microenvironment and Promotes Urethane-Induced Lung Tumorigenesis.
Title: Overexpression of PRDX4 Modulates Tumor Microenvironment and Promotes Urethane-Induced Lung Tumorigenesis.
[Differential expression of PRDX4 in alveolar macrophages of patients with silicosis].
Title: [Differential expression of PRDX4 in alveolar macrophages of patients with silicosis].
Hepatocellular carcinoma (HCC) tumors with low expression of PRDX4 had higher ROS levels, malignancy, and associated with reduced overall survival. In HCC cell lines, its knockdown led to increased intracellular ROS level and suppressed cell proliferation, inducing cell death. These results indicate that PRDX4 has an inhibitory effect in the initiation of HCC, but a dual (inhibitory or promoting) role in the progression.
Title: The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma.
The PRDX4 expression and EGFR mutation status were significantly associated with the prognosis of patients with stage I lung adenocarcinoma, and EGFR mutations affected the role of PRDX4 in the proliferation of lung adenocarcinoma cells.
Title: The impact of PRDX4 and the EGFR mutation status on cellular proliferation in lung adenocarcinoma.
PRDX4 reduces anoikis and promotes tumorigenesis and metastasis of hepatocellular carcinoma cells through stabilization of the beta-catenin protein and upregulation of ID2.
Title: Peroxiredoxin 4 suppresses anoikis and augments growth and metastasis of hepatocellular carcinoma cells through the β-catenin/ID2 pathway.
n this article, the characteristics of peroxiredoxin 4 in physiological functions and the cancer-related research progress of mammalian peroxiredoxin 4 is reviewed. We believe that peroxiredoxin 4 has the potential of serving as a novel target for multiple cancers.
Title: PRDX4 and Its Roles in Various Cancers.
These features indicate that PRDX4 plays an important role in protecting against liver injury following BDL and might be a promising therapeutic modality for cholestatic diseases.
Title: Protective Effects of Peroxiredoxin 4 (PRDX4) on Cholestatic Liver Injury.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of peroxiredoxin 1, 3, and 4 proteins in umbilical cord blood mononuclear cells and T-cell lines	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 is identified to have a physical interaction with peroxiredoxin 4 (PRDX4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC117784P1 (e-PCR)
- UniSTS:270342

PMC117784P2 (e-PCR)
- UniSTS:270343

PMC117784P3 (e-PCR)
- UniSTS:270344

PMC117784P4 (e-PCR)
- UniSTS:270345

PMC117784P5 (e-PCR)
- UniSTS:270346

PMC117784P6 (e-PCR)
- UniSTS:270347

PMC117784P7 (e-PCR)
- UniSTS:270348

D1S2039E (e-PCR)
- UniSTS:151466

PRDX4 (e-PCR)
- UniSTS:506545

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	EXP Inferred from Experiment more info	PubMed
enables molecular sequestering activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in I-kappaB phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of male germ cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by protein folding	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
located_in nucleus	HDA more info	PubMed
located_in secretory granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: peroxiredoxin-4

Names: antioxidant enzyme AOE372; epididymis secretory sperm binding protein Li 97n; peroxiredoxin IV; prx-IV; thioredoxin peroxidase (antioxidant enzyme); thioredoxin peroxidase AO372; thioredoxin-dependent peroxide reductase A0372; thioredoxin-dependent peroxiredoxin 4

NP_006397.1

EC 1.11.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012563.1 RefSeqGene

Range

4966..23870

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_006406.2 → NP_006397.1 peroxiredoxin-4 precursor

See identical proteins and their annotated locations for NP_006397.1

Status: REVIEWED

Source sequence(s)

AC093011, U25182

Consensus CDS

CCDS14206.1

UniProtKB/Swiss-Prot

Q13162, Q6FHT3

UniProtKB/TrEMBL

V9HW63

Related

ENSP00000368646.4, ENST00000379341.9

Conserved Domains (1) summary

cd03015
Location:81 → 252

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...