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Gmpr2 guanosine monophosphate reductase 2 [ Mus musculus (house mouse) ]

Gene ID: 105446, updated on 5-Mar-2024

Summary

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Official Symbol
Gmpr2provided by MGI
Official Full Name
guanosine monophosphate reductase 2provided by MGI
Primary source
MGI:MGI:1917903
See related
Ensembl:ENSMUSG00000002326 AllianceGenome:MGI:1917903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GMPR 2; 1810008P16Rik; 5730544D12Rik
Summary
Predicted to enable GMP reductase activity. Predicted to be involved in IMP salvage. Predicted to act upstream of or within GMP catabolic process and monocyte differentiation. Predicted to be part of GMP reductase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human GMPR2 (guanosine monophosphate reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 13.5), thymus adult (RPKM 12.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gmpr2 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55909692..55935602)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55672235..55687861)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene magnesium-dependent phosphatase 1 Neighboring gene neural precursor cell expressed, developmentally down-regulated gene 8 Neighboring gene Terf1 (TRF1)-interacting nuclear factor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56300752-56300861 Neighboring gene predicted gene, 25887 Neighboring gene transglutaminase 1, K polypeptide Neighboring gene STARR-seq mESC enhancer starr_36777 Neighboring gene Rab geranylgeranyl transferase, a subunit Neighboring gene STARR-positive B cell enhancer ABC_E7317

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells. Zhang J, et al. J Cancer Res Clin Oncol, 2003 Feb. PMID 12669231
  2. NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties. Deng Y, et al. Int J Biochem Cell Biol, 2002 Sep. PMID 12009299
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GMP reductase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within GMP catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in IMP salvage TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within purine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GMP reductase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GMP reductase 2
Names
guanosine 5'-monophosphate oxidoreductase 2
NP_818773.1
XP_006518429.1
XP_011243184.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177992.2 → NP_818773.1  GMP reductase 2

    See identical proteins and their annotated locations for NP_818773.1

    Status: VALIDATED

    Source sequence(s)
    AK075772, BE956837, BY099107
    Consensus CDS
    CCDS27124.1
    UniProtKB/Swiss-Prot
    Q542X2, Q8R1T5, Q99L27
    Related
    ENSMUSP00000002397.6, ENSMUST00000002397.7
    Conserved Domains (1) summary
    PRK05096
    Location:3 → 346
    PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55909692..55935602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244882.4 → XP_011243184.1  GMP reductase 2 isoform X2

    Conserved Domains (1) summary
    PRK05096
    Location:3 → 286
    PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional

  2. XM_006518366.3 → XP_006518429.1  GMP reductase 2 isoform X1

    See identical proteins and their annotated locations for XP_006518429.1

    UniProtKB/Swiss-Prot
    Q542X2, Q8R1T5, Q99L27
    Conserved Domains (1) summary
    PRK05096
    Location:3 → 346
    PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99L27.2 GenPept UniProtKB/Swiss-Prot:Q99L27

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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