CARM1 coactivator associated arginine methyltransferase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CARM1provided by HGNC
Official Full Name: coactivator associated arginine methyltransferase 1provided by HGNC
Primary source: HGNC:HGNC:23393
See related: Ensembl:ENSG00000142453 MIM:603934; AllianceGenome:HGNC:23393
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRMT4
Summary: This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]
Expression: Ubiquitous expression in testis (RPKM 20.7), placenta (RPKM 17.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (10871553..10923075)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (10998565..11050086)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (10982229..11033751)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BACH1 regulates the differentiation of vascular smooth muscle cells from human embryonic stem cells via CARM1-mediated methylation of H3R17.
Title: BACH1 regulates the differentiation of vascular smooth muscle cells from human embryonic stem cells via CARM1-mediated methylation of H3R17.
Inhibition of CARM1 suppresses proliferation of multiple myeloma cells through activation of p53 signaling pathway.
Title: Inhibition of CARM1 suppresses proliferation of multiple myeloma cells through activation of p53 signaling pathway.
PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARgamma.
Title: PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ.
Carm1-arginine methylation of the transcription factor C/EBPalpha regulates transdifferentiation velocity.
Title: Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity.
Unraveling the complexity of histone-arginine methyltransferase CARM1 in cancer: From underlying mechanisms to targeted therapeutics.
Title: Unraveling the complexity of histone-arginine methyltransferase CARM1 in cancer: From underlying mechanisms to targeted therapeutics.
Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis.
Title: Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis.
CDKN2AIP-induced cell senescence and apoptosis of testicular seminoma are associated with CARM1 and eIF4beta.
Title: CDKN2AIP-induced cell senescence and apoptosis of testicular seminoma are associated with CARM1 and eIF4β.
LYL1 facilitates AETFC assembly and gene activation by recruiting CARM1 in t(8;21) AML.
Title: LYL1 facilitates AETFC assembly and gene activation by recruiting CARM1 in t(8;21) AML.
Systematic pan-cancer landscape identifies CARM1 as a potential prognostic and immunological biomarker.
Title: Systematic pan-cancer landscape identifies CARM1 as a potential prognostic and immunological biomarker.
Histone arginine methyltransferase CARM1 selective inhibitor TP-064 induces apoptosis in endometrial cancer.
Title: Histone arginine methyltransferase CARM1 selective inhibitor TP-064 induces apoptosis in endometrial cancer.

Submit: New GeneRIF Correction See all GeneRIFs (92)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
retropepsin	gag-pol	HIV-1 PR is identified to have a physical interaction with coactivator-associated arginine methyltransferase 1 (CARM1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	TAS Traceable Author Statement more info	PubMed
enables histone H3R17 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3R17 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3R2 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3R2 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3R2 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone arginine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone methyltransferase activity	IDA Inferred from Direct Assay more info
enables lysine-acetylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear receptor coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein methyltransferase activity	IDA Inferred from Direct Assay more info
enables protein methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-arginine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-arginine N-methyltransferase activity	TAS Traceable Author Statement more info
enables protein-arginine omega-N asymmetric methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dendrite development	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of intracellular estrogen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in replication fork reversal	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cAMP	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nuclear replication fork	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone-arginine methyltransferase CARM1

Names: protein arginine N-methyltransferase 4

NP_001357017.1

EC 2.1.1.319

NP_001357018.1

EC 2.1.1.319

NP_954592.1

EC 2.1.1.319

XP_011525940.1

EC 2.1.1.319

XP_047294014.1

EC 2.1.1.319

XP_054175514.1

EC 2.1.1.319

XP_054175515.1

EC 2.1.1.319

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370088.1 → NP_001357017.1 histone-arginine methyltransferase CARM1 isoform 2

Status: VALIDATED

Source sequence(s)

AC007565, AC011442

Consensus CDS

CCDS92516.1

UniProtKB/TrEMBL

A0AA34QVH5

Related

ENSP00000340934.3, ENST00000344150.8

Conserved Domains (3) summary

cd02440
Location:188 → 283

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

COG0500
Location:184 → 394

SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

pfam11531
Location:34 → 138

CARM1; Coactivator-associated arginine methyltransferase 1 N terminal
NM_001370089.1 → NP_001357018.1 histone-arginine methyltransferase CARM1 isoform 3

Status: VALIDATED

Source sequence(s)

AC007565, AC011442

UniProtKB/TrEMBL

A0AA34QVH5

Conserved Domains (3) summary

cd02440
Location:153 → 248

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

COG0500
Location:149 → 359

SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

cl17171
Location:33 → 103

PH-like; Pleckstrin homology-like domain
NM_199141.2 → NP_954592.1 histone-arginine methyltransferase CARM1 isoform 1

See identical proteins and their annotated locations for NP_954592.1

Status: VALIDATED

Source sequence(s)

AC007565, AC011442

Consensus CDS

CCDS12250.1

UniProtKB/Swiss-Prot

A6NN38, Q86X55

UniProtKB/TrEMBL

A0AA34QVH5

Related

ENSP00000325690.4, ENST00000327064.9

Conserved Domains (3) summary

pfam05185
Location:172 → 435

PRMT5; PRMT5 arginine-N-methyltransferase

pfam11531
Location:34 → 138

CARM1; Coactivator-associated arginine methyltransferase 1 N terminal

pfam12847
Location:184 → 283

Methyltransf_18; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

10871553..10923075

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047438058.1 → XP_047294014.1 histone-arginine methyltransferase CARM1 isoform X1
XM_011527638.3 → XP_011525940.1 histone-arginine methyltransferase CARM1 isoform X2

See identical proteins and their annotated locations for XP_011525940.1

Conserved Domains (2) summary

pfam05185
Location:11 → 274

PRMT5; PRMT5 arginine-N-methyltransferase

pfam12847
Location:23 → 122

Methyltransf_18; Methyltransferase domain

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

10998565..11050086

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054319539.1 → XP_054175514.1 histone-arginine methyltransferase CARM1 isoform X1
XM_054319540.1 → XP_054175515.1 histone-arginine methyltransferase CARM1 isoform X2