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CAP1 cyclase associated actin cytoskeleton regulatory protein 1 [ Homo sapiens (human) ]

Gene ID: 10487, updated on 4-Jan-2025

Summary

Official Symbol
CAP1provided by HGNC
Official Full Name
cyclase associated actin cytoskeleton regulatory protein 1provided by HGNC
Primary source
HGNC:HGNC:20040
See related
Ensembl:ENSG00000131236 MIM:617801; AllianceGenome:HGNC:20040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAP; CAP1-PEN
Summary
The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in appendix (RPKM 105.5), lymph node (RPKM 89.3) and 25 other tissues See more
Orthologs
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Genomic context

See CAP1 in Genome Data Viewer
Location:
1p34.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40040240..40072648)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (39909560..39942077)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40505912..40538320)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:40363871-40364442 Neighboring gene MYCL antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 716 Neighboring gene MYCL proto-oncogene, bHLH transcription factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40409912-40410434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 823 Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40446045-40446898 Neighboring gene ribosomal protein S2 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 718 Neighboring gene uncharacterized LOC105378669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 824 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40505419-40506052 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40506053-40506687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40518723-40519222 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:40524580-40525341 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:40535511-40536710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 720 Neighboring gene Sharpr-MPRA regulatory region 13734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 829 Neighboring gene palmitoyl-protein thioesterase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40598557-40599056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 830 Neighboring gene uncharacterized LOC105378671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 831 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 721 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:40625521-40625722 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40626731-40627347 Neighboring gene OAZ1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding  
enables adenylate cyclase binding  
enables protein binding PubMed 
Component Evidence Code Pubs
located_in azurophil granule lumen  
located_in cortical actin cytoskeleton  
is_active_in cytoplasm  
located_in extracellular exosome PubMed 
located_in extracellular region  
located_in focal adhesion PubMed 
located_in glutamatergic synapse  
located_in plasma membrane  
located_in postsynapse  
located_in presynapse  

General protein information

Preferred Names
adenylyl cyclase-associated protein 1
Names
CAP, adenylate cyclase-associated protein 1
adenylate cyclase associated protein 1
testis secretory sperm-binding protein Li 218p

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105530.2NP_001099000.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
    UniProtKB/Swiss-Prot
    Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
    UniProtKB/TrEMBL
    B2RDY9
    Related
    ENSP00000361883.3, ENST00000372797.7
    Conserved Domains (2) summary
    pfam01213
    Location:562
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  2. NM_001330502.2NP_001317431.2  adenylyl cyclase-associated protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS81304.1
    UniProtKB/TrEMBL
    B2RDY9
    Related
    ENSP00000344832.3, ENST00000340450.7
    Conserved Domains (2) summary
    pfam01213
    Location:561
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318472
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  3. NM_001350475.2NP_001337404.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
    UniProtKB/Swiss-Prot
    Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
    UniProtKB/TrEMBL
    B2RDY9
    Conserved Domains (2) summary
    pfam01213
    Location:562
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  4. NM_001350476.2NP_001337405.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
    UniProtKB/Swiss-Prot
    Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
    UniProtKB/TrEMBL
    B2RDY9
    Conserved Domains (2) summary
    pfam01213
    Location:562
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  5. NM_001350477.3NP_001337406.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
    UniProtKB/Swiss-Prot
    Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
    UniProtKB/TrEMBL
    B2RDY9
    Related
    ENSP00000361878.2, ENST00000372792.7
    Conserved Domains (2) summary
    pfam01213
    Location:562
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  6. NM_001350478.2NP_001337407.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
    UniProtKB/Swiss-Prot
    Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
    UniProtKB/TrEMBL
    B2RDY9
    Conserved Domains (2) summary
    pfam01213
    Location:562
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  7. NM_001350479.2NP_001337408.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
    UniProtKB/Swiss-Prot
    Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
    UniProtKB/TrEMBL
    B2RDY9
    Conserved Domains (2) summary
    pfam01213
    Location:562
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  8. NM_001350480.2NP_001337409.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
    UniProtKB/Swiss-Prot
    Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
    UniProtKB/TrEMBL
    B2RDY9
    Conserved Domains (2) summary
    pfam01213
    Location:562
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  9. NM_001350481.2NP_001337410.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
    UniProtKB/Swiss-Prot
    Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
    UniProtKB/TrEMBL
    B2RDY9
    Conserved Domains (2) summary
    pfam01213
    Location:562
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  10. NM_001350482.2NP_001337411.2  adenylyl cyclase-associated protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS81304.1
    UniProtKB/TrEMBL
    B2RDY9
    Related
    ENSP00000361884.1, ENST00000372798.5
    Conserved Domains (2) summary
    pfam01213
    Location:561
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318472
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  11. NM_001350483.2NP_001337412.2  adenylyl cyclase-associated protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS81304.1
    UniProtKB/TrEMBL
    B2RDY9
    Related
    ENSP00000361888.1, ENST00000372802.5
    Conserved Domains (2) summary
    pfam01213
    Location:561
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318472
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  12. NM_001350484.2NP_001337413.2  adenylyl cyclase-associated protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS81304.1
    UniProtKB/TrEMBL
    B2RDY9
    Conserved Domains (2) summary
    pfam01213
    Location:561
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318472
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  13. NM_001350485.2NP_001337414.2  adenylyl cyclase-associated protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS81304.1
    UniProtKB/TrEMBL
    B2RDY9
    Conserved Domains (2) summary
    pfam01213
    Location:561
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318472
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  14. NM_006367.4NP_006358.2  adenylyl cyclase-associated protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 4-10 encode the same isoform (a).
    Source sequence(s)
    AL512599
    Consensus CDS
    CCDS41309.1
    UniProtKB/Swiss-Prot
    Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
    UniProtKB/TrEMBL
    B2RDY9
    Related
    ENSP00000361891.3, ENST00000372805.8
    Conserved Domains (2) summary
    pfam01213
    Location:562
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319473
    CAP_C; Adenylate cyclase associated (CAP) C terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    40040240..40072648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431628.1XP_047287584.1  adenylyl cyclase-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RDY9
  2. XM_047431636.1XP_047287592.1  adenylyl cyclase-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RDY9
  3. XM_047431520.1XP_047287476.1  adenylyl cyclase-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RDY9
  4. XM_047431420.1XP_047287376.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
    UniProtKB/TrEMBL
    B2RDY9
  5. XM_011540515.2XP_011538817.1  adenylyl cyclase-associated protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011538817.1

    UniProtKB/TrEMBL
    B2RDY9
    Conserved Domains (2) summary
    pfam01213
    Location:561
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318472
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  6. XM_011540510.2XP_011538812.1  adenylyl cyclase-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011538812.1

    UniProtKB/Swiss-Prot
    Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
    UniProtKB/TrEMBL
    B2RDY9
    Conserved Domains (2) summary
    pfam01213
    Location:562
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  7. XM_047431603.1XP_047287559.1  adenylyl cyclase-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RDY9
  8. XM_017000069.2XP_016855558.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
    UniProtKB/TrEMBL
    B2RDY9
    Conserved Domains (2) summary
    pfam01213
    Location:562
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  9. XM_047431580.1XP_047287536.1  adenylyl cyclase-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RDY9
  10. XM_047431489.1XP_047287445.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
    UniProtKB/TrEMBL
    B2RDY9
  11. XM_047431616.1XP_047287572.1  adenylyl cyclase-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RDY9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    39909560..39942077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333863.1XP_054189838.1  adenylyl cyclase-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RDY9
  2. XM_054333864.1XP_054189839.1  adenylyl cyclase-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RDY9
  3. XM_054333858.1XP_054189833.1  adenylyl cyclase-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RDY9
  4. XM_054333854.1XP_054189829.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    B2RDY9, D3DPU2
  5. XM_054333859.1XP_054189834.1  adenylyl cyclase-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RDY9
  6. XM_054333856.1XP_054189831.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    B2RDY9, D3DPU2
  7. XM_054333861.1XP_054189836.1  adenylyl cyclase-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RDY9
  8. XM_054333855.1XP_054189830.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    B2RDY9, D3DPU2
  9. XM_054333860.1XP_054189835.1  adenylyl cyclase-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RDY9
  10. XM_054333857.1XP_054189832.1  adenylyl cyclase-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    B2RDY9, D3DPU2
  11. XM_054333862.1XP_054189837.1  adenylyl cyclase-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RDY9
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