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Cabin1 calcineurin binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 104248, updated on 5-Mar-2024

Summary

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Official Symbol
Cabin1provided by MGI
Official Full Name
calcineurin binding protein 1provided by MGI
Primary source
MGI:MGI:1298375
See related
Ensembl:ENSMUSG00000020196 AllianceGenome:MGI:1298375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cain; Ppp3in; A330070M20Rik
Summary
Predicted to enable protein domain specific binding activity; protein phosphatase 2B binding activity; and protein phosphatase inhibitor activity. Predicted to contribute to nucleosome binding activity. Predicted to be involved in DNA replication-independent chromatin assembly and negative regulation of cell death. Predicted to act upstream of or within signal transduction. Predicted to be located in aggresome; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in heart. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CABIN1 (calcineurin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 14.2), ovary adult (RPKM 14.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 38.56 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75481944..75600194, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75646110..75764357, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19688 Neighboring gene STARR-seq mESC enhancer starr_27156 Neighboring gene sushi domain containing 2 Neighboring gene predicted gene, 40696 Neighboring gene STARR-positive B cell enhancer mm9_chr10:75226990-75227291 Neighboring gene STARR-positive B cell enhancer ABC_E9346 Neighboring gene cytochrome b-c1 complex subunit 7 pseudogene Neighboring gene D-dopachrome tautomerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Impact of Electrographic Seizures on Developing Hippocampal Dendrites Is Calcineurin Dependent. Nishimura M, et al. eNeuro, 2017 Mar-Apr. PMID 28462391, Free PMC Article
  2. Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death. Kim MJ, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12114545, Free PMC Article
  3. HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype. Smith R, et al. Reproduction, 2021 May 10. PMID 33835048, Free PMC Article
  4. The H3.3 chaperone Hira complex orchestrates oocyte developmental competence. Smith R, et al. Development, 2022 Mar 1. PMID 35112132, Free PMC Article
  5. Calcineurin inhibitor protein (CAIN) attenuates Group I metabotropic glutamate receptor endocytosis and signaling. Ferreira LT, et al. J Biol Chem, 2009 Oct 16. PMID 19717561, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 2B binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
calcineurin-binding protein cabin-1
Names
calcineurin inhibitor
protein phosphatase 3 inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172549.3 → NP_766137.2  calcineurin-binding protein cabin-1

    See identical proteins and their annotated locations for NP_766137.2

    Status: VALIDATED

    Source sequence(s)
    AK039606, BC051668, BC057551, BQ714836, BU705499, CN722898, CV884170
    Consensus CDS
    CCDS35938.1
    UniProtKB/TrEMBL
    B9EKC5, G3X8Q1
    Related
    ENSMUSP00000001712.7, ENSMUST00000001712.8
    Conserved Domains (4) summary
    PHA03247
    Location:1915 → 2161
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:34 → 210
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:90 → 118
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:2123 → 2157
    MEF2_binding; MEF2 binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    75481944..75600194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513020.5 → XP_006513083.1  calcineurin-binding protein cabin-1 isoform X2

    UniProtKB/TrEMBL
    B9EKC5
    Conserved Domains (4) summary
    PHA03247
    Location:1886 → 2132
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:34 → 210
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:90 → 118
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:2094 → 2128
    MEF2_binding; MEF2 binding

  2. XM_006513019.5 → XP_006513082.1  calcineurin-binding protein cabin-1 isoform X1

    See identical proteins and their annotated locations for XP_006513082.1

    UniProtKB/TrEMBL
    B9EKC5, G3X8Q1
    Conserved Domains (4) summary
    PHA03247
    Location:1915 → 2161
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:34 → 210
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:90 → 118
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:2123 → 2157
    MEF2_binding; MEF2 binding

  3. XM_006513021.3 → XP_006513084.1  calcineurin-binding protein cabin-1 isoform X3

    Conserved Domains (3) summary
    sd00006
    Location:191 → 218
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:1258 → 1292
    MEF2_binding; MEF2 binding
    pfam15058
    Location:1111 → 1258
    Speriolin_N; Speriolin N-terminus

  4. XM_006513022.3 → XP_006513085.1  calcineurin-binding protein cabin-1 isoform X4

    Conserved Domains (2) summary
    pfam09047
    Location:1045 → 1079
    MEF2_binding; MEF2 binding
    pfam15058
    Location:898 → 1045
    Speriolin_N; Speriolin N-terminus

RNA

  1. XR_001779404.2 RNA Sequence

  2. XR_001779405.3 RNA Sequence

  3. XR_380334.5 RNA Sequence

  4. XR_001779406.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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