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Adcy4 adenylate cyclase 4 [ Mus musculus (house mouse) ]

Gene ID: 104110, updated on 11-Apr-2024

Summary

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Official Symbol
Adcy4provided by MGI
Official Full Name
adenylate cyclase 4provided by MGI
Primary source
MGI:MGI:99674
See related
Ensembl:ENSMUSG00000022220 AllianceGenome:MGI:99674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4004
Summary
Predicted to enable G-protein beta/gamma-subunit complex binding activity; adenylate cyclase activity; and protein kinase C binding activity. Acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in dendrite. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and hemolymphoid system. Orthologous to human ADCY4 (adenylate cyclase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 35.4), subcutaneous fat pad adult (RPKM 10.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C3; 14 28.19 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56006513..56021552, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55769056..55784095, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36778 Neighboring gene cell death-inducing DNA fragmentation factor, alpha subunit-like effector B Neighboring gene leukotriene B4 receptor 2 Neighboring gene leukotriene B4 receptor 1 Neighboring gene predicted gene, 32092 Neighboring gene receptor-interacting serine-threonine kinase 3 Neighboring gene STARR-positive B cell enhancer mm9_chr14:56441298-56441599 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure. Chen K, et al. Transl Res, 2022 Jun. PMID 35114419, Free PMC Article
  2. Adenylyl cyclase 4 does not regulate collecting duct water and sodium handling. Kittikulsuth W, et al. Physiol Rep, 2014. PMID 24760529, Free PMC Article
  3. Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4. Al-Hakim A, et al. Mol Cell Endocrinol, 2004 Feb 12. PMID 15062554
  4. Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Gao BN, et al. Proc Natl Acad Sci U S A, 1991 Nov 15. PMID 1946437, Free PMC Article
  5. Contributions of specificity protein-1 and steroidogenic factor 1 to Adcy4 expression in Y1 mouse adrenal cells. Rui X, et al. Endocrinology, 2008 Jul. PMID 18388192, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure.
    Title: In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure.
  2. SF1 and SP1 contribute to Adcy4 promoter activity via interation with conserved region situated 19 bp upstream of the major transcription start site.
    Title: Contributions of specificity protein-1 and steroidogenic factor 1 to Adcy4 expression in Y1 mouse adrenal cells.
  3. Adcy4 deficiency is a hallmark of the forskolin-resistant phenotype of the adrenocortical tumor mutants studied and Adcy4 is an important target of forskolin action in the Y1 adrenal cell line.
    Title: Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4004

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables G-protein beta/gamma-subunit complex binding ISO
Inferred from Sequence Orthology
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables adenylate cyclase activity TAS
Traceable Author Statement
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cAMP biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adenylate cyclase type 4
Names
ATP pyrophosphate-lyase 4
adenylate cyclase type IV
adenylyl cyclase 4
NP_001348533.1
NP_536683.1
XP_006518387.1
XP_006518388.1
XP_006518389.1
XP_036014230.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361604.1 → NP_001348533.1  adenylate cyclase type 4

    Status: VALIDATED

    Source sequence(s)
    AC098877, AK141767, BY346402
    Consensus CDS
    CCDS27130.1
    UniProtKB/Swiss-Prot
    Q91WF3
    UniProtKB/TrEMBL
    Q3UR61
    Related
    ENSMUSP00000130530.2, ENSMUST00000170223.9
    Conserved Domains (3) summary
    pfam00211
    Location:866 → 1065
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:115 → 246
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:479 → 580
    DUF1053; Domain of Unknown Function (DUF1053)

  2. NM_080435.2 → NP_536683.1  adenylate cyclase type 4

    See identical proteins and their annotated locations for NP_536683.1

    Status: VALIDATED

    Source sequence(s)
    AC098877, AK141767, AK161880, BY346402
    Consensus CDS
    CCDS27130.1
    UniProtKB/Swiss-Prot
    Q91WF3
    UniProtKB/TrEMBL
    Q3UR61
    Related
    ENSMUSP00000002398.8, ENSMUST00000002398.9
    Conserved Domains (3) summary
    pfam00211
    Location:866 → 1065
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:115 → 246
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:479 → 580
    DUF1053; Domain of Unknown Function (DUF1053)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    56006513..56021552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518324.1 → XP_006518387.1  adenylate cyclase type 4 isoform X1

    See identical proteins and their annotated locations for XP_006518387.1

    UniProtKB/Swiss-Prot
    Q91WF3
    UniProtKB/TrEMBL
    Q3UR61
    Conserved Domains (3) summary
    pfam00211
    Location:866 → 1065
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:115 → 246
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:479 → 580
    DUF1053; Domain of Unknown Function (DUF1053)

  2. XM_036158337.1 → XP_036014230.1  adenylate cyclase type 4 isoform X4

    Conserved Domains (3) summary
    pfam00211
    Location:525 → 724
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:138 → 239
    DUF1053; Domain of Unknown Function (DUF1053)
    cl11967
    Location:15 → 77
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

  3. XM_006518326.3 → XP_006518389.1  adenylate cyclase type 4 isoform X3

    Conserved Domains (3) summary
    pfam00211
    Location:552 → 751
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:165 → 266
    DUF1053; Domain of Unknown Function (DUF1053)
    cl11967
    Location:2 → 104
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

  4. XM_006518325.3 → XP_006518388.1  adenylate cyclase type 4 isoform X2

    UniProtKB/TrEMBL
    Q3TSQ4, Q3UR61
    Conserved Domains (4) summary
    pfam00211
    Location:264 → 418
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:115 → 246
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:479 → 580
    DUF1053; Domain of Unknown Function (DUF1053)
    cl11967
    Location:866 → 939
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WF3.1 GenPept UniProtKB/Swiss-Prot:Q91WF3

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