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CDK7 cyclin dependent kinase 7 [ Homo sapiens (human) ]

Gene ID: 1022, updated on 11-Apr-2024

Summary

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Official Symbol
CDK7provided by HGNC
Official Full Name
cyclin dependent kinase 7provided by HGNC
Primary source
HGNC:HGNC:1778
See related
Ensembl:ENSG00000134058 MIM:601955; AllianceGenome:HGNC:1778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAK; CAK1; HCAK; MO15; STK1; CDKN7; p39MO15
Summary
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 18.1), placenta (RPKM 14.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See CDK7 in Genome Data Viewer
Location:
5q13.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (69234795..69277430)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (70060554..70103173)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (68530622..68573257)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 51 Neighboring gene centromere protein H Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22641 Neighboring gene Sharpr-MPRA regulatory region 69 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68515812-68516436 Neighboring gene alpha-ketoglutarate dehydrogenase subunit 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68530435-68530963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:68532675-68533175 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68545886-68546386 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68546387-68546887 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68561629-68562129 Neighboring gene coiled-coil domain containing 125 Neighboring gene cofilin 1 pseudogene 5 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhibition of CDK7-dependent transcriptional addiction is a potential therapeutic target in synovial sarcoma. Li X, et al. Biomed Pharmacother, 2022 May. PMID 35367753
  2. Cyclin-Dependent Kinase 7 Promotes Th17/Th1 Cell Differentiation in Psoriasis by Modulating Glycolytic Metabolism. Lin Y, et al. J Invest Dermatol, 2021 Nov. PMID 34004188
  3. Pharmacological inhibition of CDK7 by THZ1 impairs tumor growth in p53-mutated HNSCC. Ge H, et al. Oral Dis, 2022 Apr. PMID 33503275
  4. Overexpression of CDK7 is associated with unfavourable prognosis in oral squamous cell carcinoma. Jiang L, et al. Pathology, 2019 Jan. PMID 30473182
  5. CDK7 activated beta-catenin/TCF signaling in hepatocellular carcinoma. Duan J, et al. Exp Cell Res, 2018 Sep 15. PMID 29981747

See all (222) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity.
    Title: CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity.
  2. Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency.
    Title: Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency.
  3. Disruption of CDK7 signaling leads to catastrophic chromosomal instability coupled with a loss of condensin-mediated chromatin compaction.
    Title: Disruption of CDK7 signaling leads to catastrophic chromosomal instability coupled with a loss of condensin-mediated chromatin compaction.
  4. Castration-resistant prostate cancer cells are dependent on the high activity of CDK7.
    Title: Castration-resistant prostate cancer cells are dependent on the high activity of CDK7.
  5. Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression.
    Title: Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression.
  6. CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.
    Title: CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.
  7. Targeting cyclin-dependent kinase 7-association between CDK7 and pMED1 expression in prostate cancer tissue.
    Title: Targeting cyclin-dependent kinase 7-association between CDK7 and pMED1 expression in prostate cancer tissue.
  8. Inhibition of CDK7-dependent transcriptional addiction is a potential therapeutic target in synovial sarcoma.
    Title: Inhibition of CDK7-dependent transcriptional addiction is a potential therapeutic target in synovial sarcoma.
  9. Pharmacological inhibition of CDK7 by THZ1 impairs tumor growth in p53-mutated HNSCC.
    Title: Pharmacological inhibition of CDK7 by THZ1 impairs tumor growth in p53-mutated HNSCC.
  10. An integrative multi-omics approach uncovers the regulatory role of CDK7 and CDK4 in autophagy activation induced by silica nanoparticles.
    Title: An integrative multi-omics approach uncovers the regulatory role of CDK7 and CDK4 in autophagy activation induced by silica nanoparticles.
Submit: New GeneRIF Correction See all GeneRIFs (61)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIH, during Tat-mediated transactivation of the HIV-1 LTR PubMed
tat TFIIH subunits CDK7 and cyclin H have been identified as two components associated with the Tat-associated CTD kinase (TTK) that binds to HIV-1 Tat PubMed
tat Phosphorylation of CDK7 by CDK2 is involved in the interaction of HIV-1 Tat with CDK7 and subsequent activation of HIV-1 transactivation of the HIV-1 LTR promoter PubMed
tat TFIIH synergizes with HIV-1 Tat to induce transcription elongation from the HIV-1 LTR promoter PubMed
tat Interaction of HIV-1 Tat with TFIIH stimulates phosphorylation of Ser-5 of the RNA polymerase II C-terminal domain (CTD), which in turn also stimulates co-transcriptional capping of HIV-1 mRNA PubMed
tat TFIIH interacts with HIV-1 Tat as a component of the HIV-1 transcription preinitiation complex, but is released from the elongation complex which includes P-TEFb PubMed
tat CAK/TFIIH is required for HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
tat Amino acids 1-48 of HIV-1 Tat, which includes the Tat activation domain, mediate the binding of Tat to CAK and the TFIIH complex through a direct interaction with CDK7 and possibly other TFIIH subunits, including p62 and ERCC3 PubMed
Vpr vpr As a component of the TFIIH transcription complex, CDK7 inhibits HIV-1 Vpr cell cycle-arresting function PubMed
vpr As a component of the TFIIH transcription complex, CDK7 enhances the synergistic activation of glucocorticoid receptor by HIV-1 Vpr and p300 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
  
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
  
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of CAK-ERCC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cyclin-dependent protein kinase activating kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
located_in male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
part_of transcription factor TFIIH core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIH holo complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIK complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIK complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIK complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
cyclin-dependent kinase 7
Names
39 KDa protein kinase
CDK-activating kinase 1
TFIIH basal transcription factor complex kinase subunit
cell division protein kinase 7
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
homolog of Xenopus MO15 Cdk-activating kinase
kinase subunit of CAK
serine/threonine kinase stk1
serine/threonine protein kinase 1
serine/threonine protein kinase MO15
NP_001310998.1
NP_001310999.1
NP_001311000.1
NP_001311001.1
NP_001311003.1
NP_001311004.1
NP_001311006.1
NP_001311007.1
NP_001790.1
XP_011541396.1
XP_047272565.1
XP_054185464.1
XP_054207386.1
XP_054207387.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324069.2 → NP_001310998.1  cyclin-dependent kinase 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC005298, BI520184, CA437275, L20320
    UniProtKB/TrEMBL
    D6RAD4
    Conserved Domains (1) summary
    cd07841
    Location:2 → 267
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

  2. NM_001324070.2 → NP_001310999.1  cyclin-dependent kinase 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK308493, BC000834, CA437275
    UniProtKB/Swiss-Prot
    P50613
    Conserved Domains (1) summary
    cd07841
    Location:11 → 251
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

  3. NM_001324071.2 → NP_001311000.1  cyclin-dependent kinase 7 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC145132, BC000834, BC005298, CA437275
    UniProtKB/Swiss-Prot
    P50613
    Conserved Domains (1) summary
    cl21453
    Location:43 → 251
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001324072.1 → NP_001311001.1  cyclin-dependent kinase 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC145132
    Consensus CDS
    CCDS83002.1
    UniProtKB/TrEMBL
    D6R9G1
    Conserved Domains (1) summary
    cd07841
    Location:1 → 215
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

  5. NM_001324074.2 → NP_001311003.1  cyclin-dependent kinase 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC145132
    Consensus CDS
    CCDS83002.1
    UniProtKB/TrEMBL
    D6R9G1
    Conserved Domains (1) summary
    cd07841
    Location:1 → 215
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

  6. NM_001324075.2 → NP_001311004.1  cyclin-dependent kinase 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC145132
    Consensus CDS
    CCDS83002.1
    UniProtKB/TrEMBL
    D6R9G1
    Conserved Domains (1) summary
    cd07841
    Location:1 → 215
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

  7. NM_001324077.1 → NP_001311006.1  cyclin-dependent kinase 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    BC005298, BI520184, BU660651, CA305960, CA437275
    Consensus CDS
    CCDS83002.1
    UniProtKB/TrEMBL
    D6R9G1
    Related
    ENSP00000422121.1, ENST00000502604.5
    Conserved Domains (1) summary
    cd07841
    Location:1 → 215
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

  8. NM_001324078.2 → NP_001311007.1  cyclin-dependent kinase 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    BI520184, CA437275, KU177971
    Consensus CDS
    CCDS83002.1
    UniProtKB/TrEMBL
    D6R9G1
    Conserved Domains (1) summary
    cd07841
    Location:1 → 215
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

  9. NM_001799.4 → NP_001790.1  cyclin-dependent kinase 7 isoform 1

    See identical proteins and their annotated locations for NP_001790.1

    Status: VALIDATED

    Source sequence(s)
    BC000834, BC005298, BI520184, CA437275
    Consensus CDS
    CCDS3999.1
    UniProtKB/Swiss-Prot
    P50613, Q9BS60, Q9UE19
    UniProtKB/TrEMBL
    A0A0S2Z3F9, D6RAD4
    Related
    ENSP00000256443.3, ENST00000256443.8
    Conserved Domains (1) summary
    cd07841
    Location:11 → 308
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

RNA

  1. NR_136690.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC145132

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    69234795..69277430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416609.1 → XP_047272565.1  cyclin-dependent kinase 7 isoform X1

  2. XM_011543094.3 → XP_011541396.1  cyclin-dependent kinase 7 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1 → 191
    PKc_like; Protein Kinases, catalytic domain

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315917.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    17975..60596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329489.1 → XP_054185464.1  cyclin-dependent kinase 7 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    70060554..70103173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351411.1 → XP_054207386.1  cyclin-dependent kinase 7 isoform X1

  2. XM_054351412.1 → XP_054207387.1  cyclin-dependent kinase 7 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50613.1 GenPept UniProtKB/Swiss-Prot:P50613

Gene LinkOut

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