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SGK2 serum/glucocorticoid regulated kinase 2 [ Homo sapiens (human) ]

Gene ID: 10110, updated on 4-Jan-2025

Summary

Official Symbol
SGK2provided by HGNC
Official Full Name
serum/glucocorticoid regulated kinase 2provided by HGNC
Primary source
HGNC:HGNC:13900
See related
Ensembl:ENSG00000101049 MIM:607589; AllianceGenome:HGNC:13900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H-SGK2; dJ138B7.2
Summary
This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Expression
Biased expression in kidney (RPKM 17.8), colon (RPKM 13.6) and 8 other tissues See more
Orthologs
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Genomic context

See SGK2 in Genome Data Viewer
Location:
20q13.12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (43559027..43585627)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (45292229..45318829)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (42187667..42214267)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1251, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12927 Neighboring gene L3MBTL histone methyl-lysine binding protein 1 Neighboring gene transmembrane protein 14C-like Neighboring gene ReSE screen-validated silencer GRCh37_chr20:42173308-42173524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17904 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42236005-42236846 Neighboring gene intraflagellar transport 52 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:42266543-42266756 Neighboring gene ribosomal protein L27a pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Items 1 - 25 of 28
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables potassium channel regulator activity  
enables potassium channel regulator activity PubMed 
enables protein binding PubMed 
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
enables sodium channel regulator activity PubMed 
enables sodium channel regulator activity PubMed 
Items 1 - 25 of 28
Component Evidence Code Pubs
located_in cytosol  
located_in nucleoplasm  

General protein information

Preferred Names
serine/threonine-protein kinase Sgk2
Names
SGK2, serine/threonine kinase 2
NP_001186193.1
NP_057360.3
NP_733794.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029448.2 RefSeqGene

    Range
    5033..31633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1050

mRNA and Protein(s)

  1. NM_001199264.2NP_001186193.1  serine/threonine-protein kinase Sgk2

    See identical proteins and their annotated locations for NP_001186193.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region, compared to variant 2. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    BC065511, DA244897
    Consensus CDS
    CCDS13321.1
    UniProtKB/Swiss-Prot
    Q52PK5, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9HBY8, Q9UKG6
    UniProtKB/TrEMBL
    A8K0N1
    Related
    ENSP00000392795.3, ENST00000423407.7
    Conserved Domains (1) summary
    cd05603
    Location:39359
    STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2
  2. NM_016276.5NP_057360.3  serine/threonine-protein kinase Sgk2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest transcript. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AF186470, BC065511, CD627734, Z98752
    Consensus CDS
    CCDS13321.1
    UniProtKB/Swiss-Prot
    Q52PK5, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9HBY8, Q9UKG6
    UniProtKB/TrEMBL
    A8K0N1
    Related
    ENSP00000340608.5, ENST00000341458.10
    Conserved Domains (1) summary
    cd05603
    Location:39359
    STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2
  3. NM_170693.3NP_733794.1  serine/threonine-protein kinase Sgk2

    See identical proteins and their annotated locations for NP_733794.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains an alternate in-frame exon in the 5' coding region, compared to variant 2. Variants 1, 2 and 3 all encode the same protein.
    Source sequence(s)
    AF169034, BC065511, DB183229
    Consensus CDS
    CCDS13321.1
    UniProtKB/Swiss-Prot
    Q52PK5, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9HBY8, Q9UKG6
    UniProtKB/TrEMBL
    A8K0N1
    Related
    ENSP00000362192.1, ENST00000373100.7
    Conserved Domains (1) summary
    cd05603
    Location:39359
    STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    43559027..43585627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    45292229..45318829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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