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PAK6 p21 (RAC1) activated kinase 6 [ Canis lupus familiaris (dog) ]

Gene ID: 100856038, updated on 8-Mar-2024

Summary

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Official Symbol
PAK6provided by VGNC
Official Full Name
p21 (RAC1) activated kinase 6provided by VGNC
Primary source
VGNC:VGNC:111618
See related
Ensembl:ENSCAFG00845027493
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 30
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 30 NC_051834.1 (7553994..7588094)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 30 NC_006612.4 (7478897..7516220)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 30 NC_049251.1 (7709827..7747189)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 30 NC_049290.1 (7475297..7512646)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 30 NC_049771.1 (7581248..7618595)

Chromosome 30 - NC_051834.1Genomic Context describing neighboring genes Neighboring gene Bcl2 modifying factor Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase B Neighboring gene uncharacterized LOC102157096 Neighboring gene ankyrin repeat domain 63 Neighboring gene phospholipase C beta 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 6; serine/threonine-protein kinase PAK 6
Names
p21 protein (Cdc42/Rac)-activated kinase 6
p21(CDKN1A)-activated kinase 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051834.1 Reference ROS_Cfam_1.0

    Range
    7553994..7588094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038441956.1 → XP_038297884.1  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I3QDZ0
    Related
    ENSCAFP00845038052.1, ENSCAFT00845048505.1
    Conserved Domains (2) summary
    cd06659
    Location:372 → 668
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049290.1 Alternate UMICH_Zoey_3.1

    Range
    7475297..7512646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038516443.1 → XP_038372371.1  serine/threonine-protein kinase PAK 6 isoform X2

    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  2. XM_038516444.1 → XP_038372372.1  serine/threonine-protein kinase PAK 6 isoform X2

    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  3. XM_038516448.1 → XP_038372376.1  serine/threonine-protein kinase PAK 6 isoform X3

    Conserved Domains (2) summary
    cd06659
    Location:377 → 673
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  4. XM_038516445.1 → XP_038372373.1  serine/threonine-protein kinase PAK 6 isoform X2

    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  5. XM_038516447.1 → XP_038372375.1  serine/threonine-protein kinase PAK 6 isoform X2

    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  6. XM_038516446.1 → XP_038372374.1  serine/threonine-protein kinase PAK 6 isoform X2

    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049771.1 Alternate UNSW_CanFamBas_1.0

    Range
    7581248..7618595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038644306.1 → XP_038500234.1  serine/threonine-protein kinase PAK 6 isoform X4

  2. XM_038644307.1 → XP_038500235.1  serine/threonine-protein kinase PAK 6 isoform X4

  3. XM_038644312.1 → XP_038500240.1  serine/threonine-protein kinase PAK 6 isoform X5

  4. XM_038644308.1 → XP_038500236.1  serine/threonine-protein kinase PAK 6 isoform X4

  5. XM_038644311.1 → XP_038500239.1  serine/threonine-protein kinase PAK 6 isoform X4

  6. XM_038644309.1 → XP_038500237.1  serine/threonine-protein kinase PAK 6 isoform X4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049251.1 Alternate UU_Cfam_GSD_1.0

    Range
    7709827..7747189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038580033.1 → XP_038435961.1  serine/threonine-protein kinase PAK 6 isoform X6

    UniProtKB/TrEMBL
    A0A8C0JWS2, A0A8C0PC51, A0A8C0Z6X2, A0A8P0SE29
    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  2. XM_038580034.1 → XP_038435962.1  serine/threonine-protein kinase PAK 6 isoform X6

    UniProtKB/TrEMBL
    A0A8C0JWS2, A0A8C0PC51, A0A8C0Z6X2, A0A8P0SE29
    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  3. XM_038580038.1 → XP_038435966.1  serine/threonine-protein kinase PAK 6 isoform X7

    UniProtKB/TrEMBL
    A0A8C0PC51
    Conserved Domains (2) summary
    cd06659
    Location:377 → 673
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  4. XM_038580035.1 → XP_038435963.1  serine/threonine-protein kinase PAK 6 isoform X6

    UniProtKB/TrEMBL
    A0A8C0JWS2, A0A8C0PC51, A0A8C0Z6X2, A0A8P0SE29
    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  5. XM_038580032.1 → XP_038435960.1  serine/threonine-protein kinase PAK 6 isoform X6

    UniProtKB/TrEMBL
    A0A8C0JWS2, A0A8C0PC51, A0A8C0Z6X2, A0A8P0SE29
    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  6. XM_038580037.1 → XP_038435965.1  serine/threonine-protein kinase PAK 6 isoform X6

    UniProtKB/TrEMBL
    A0A8C0JWS2, A0A8C0PC51, A0A8C0Z6X2, A0A8P0SE29
    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  7. XM_038580036.1 → XP_038435964.1  serine/threonine-protein kinase PAK 6 isoform X6

    UniProtKB/TrEMBL
    A0A8C0JWS2, A0A8C0PC51, A0A8C0Z6X2, A0A8P0SE29
    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    7478897..7516220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022413037.2 → XP_022268745.1  serine/threonine-protein kinase PAK 6 isoform X8

    UniProtKB/TrEMBL
    A0A8C0JWS2, A0A8C0PC51, A0A8C0Z6X2, A0A8P0SE29
    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  2. XM_038461365.1 → XP_038317293.1  serine/threonine-protein kinase PAK 6 isoform X8

    UniProtKB/TrEMBL
    A0A8C0JWS2, A0A8C0PC51, A0A8C0Z6X2, A0A8P0SE29
    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  3. XM_005638237.4 → XP_005638294.1  serine/threonine-protein kinase PAK 6 isoform X9

    UniProtKB/TrEMBL
    A0A8C0PC51
    Conserved Domains (2) summary
    cd06659
    Location:377 → 673
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  4. XM_022413039.2 → XP_022268747.1  serine/threonine-protein kinase PAK 6 isoform X8

    UniProtKB/TrEMBL
    A0A8C0JWS2, A0A8C0PC51, A0A8C0Z6X2, A0A8P0SE29
    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  5. XM_038461366.1 → XP_038317294.1  serine/threonine-protein kinase PAK 6 isoform X8

    UniProtKB/TrEMBL
    A0A8C0JWS2, A0A8C0PC51, A0A8C0Z6X2, A0A8P0SE29
    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain

  6. XM_022413038.2 → XP_022268746.1  serine/threonine-protein kinase PAK 6 isoform X8

    UniProtKB/TrEMBL
    A0A8C0JWS2, A0A8C0PC51, A0A8C0Z6X2, A0A8P0SE29
    Conserved Domains (2) summary
    cd06659
    Location:385 → 681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:11 → 67
    PBD; P21-Rho-binding domain
Nucleotide Protein
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