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EP300 E1A binding protein p300 [ Canis lupus familiaris (dog) ]

Gene ID: 100684945, updated on 8-Mar-2024

Summary

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Official Symbol
EP300provided by VGNC
Official Full Name
E1A binding protein p300provided by VGNC
Primary source
VGNC:VGNC:84862
See related
Ensembl:ENSCAFG00845018383
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
31
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (24823553..24904040, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (24010660..24090852, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (25034546..25114749, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (24539621..24619804, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (24860221..24940412, complement)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene chondroadherin like Neighboring gene L3MBTL histone methyl-lysine binding protein 2 Neighboring gene uncharacterized LOC102155369 Neighboring gene small nucleolar RNA U13 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106559373 Neighboring gene uncharacterized LOC119873626 Neighboring gene uncharacterized LOC111097642

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone acetyltransferase p300
XP_038344445.1
XP_038344446.1
XP_038406374.1
XP_038406375.1
XP_038470340.1
XP_038470341.1
XP_038494459.1
XP_038494469.1
XP_038535681.1
XP_038535682.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    24823553..24904040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038679753.1 → XP_038535681.1  histone acetyltransferase p300 isoform X1

    UniProtKB/TrEMBL
    A0A8C0P7Y1, A0A8C0T224, A0A8I3P730
    Related
    ENSCAFP00845025456.1, ENSCAFT00845032551.1
    Conserved Domains (11) summary
    cd05495
    Location:1054 → 1161
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    TIGR01628
    Location:647 → 816
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd02337
    Location:1671 → 1711
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1173 → 1245
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1246 → 1280
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam09606
    Location:1995 → 2366
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02172
    Location:567 → 647
    KIX; KIX domain
    pfam02135
    Location:348 → 415
    zf-TAZ; TAZ zinc finger
    pfam03154
    Location:642 → 992
    Atrophin-1; Atrophin-1 family
    pfam08214
    Location:1309 → 1615
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1997 → 2101
    Creb_binding; Creb binding

  2. XM_038679754.1 → XP_038535682.1  histone acetyltransferase p300 isoform X2

    UniProtKB/TrEMBL
    A0A8C0PIR7, A0A8C0T1V5, A0A8I3P1J8
    Related
    ENSCAFP00845026037.1, ENSCAFT00845033258.1
    Conserved Domains (10) summary
    cd05495
    Location:994 → 1101
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    TIGR01628
    Location:647 → 816
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd02337
    Location:1611 → 1651
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1113 → 1185
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1186 → 1220
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam09606
    Location:1935 → 2306
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02172
    Location:567 → 647
    KIX; KIX domain
    pfam02135
    Location:348 → 415
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1249 → 1555
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1937 → 2041
    Creb_binding; Creb binding

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    24539621..24619804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038488517.1 → XP_038344445.1  histone acetyltransferase p300 isoform X1

  2. XM_038488518.1 → XP_038344446.1  histone acetyltransferase p300 isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    24860221..24940412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038614412.1 → XP_038470340.1  histone acetyltransferase p300 isoform X1

  2. XM_038614413.1 → XP_038470341.1  histone acetyltransferase p300 isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    25034546..25114749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038550446.1 → XP_038406374.1  histone acetyltransferase p300 isoform X1

    UniProtKB/TrEMBL
    A0A8C0P7Y1, A0A8C0T224, A0A8I3P730
    Conserved Domains (11) summary
    cd05495
    Location:1054 → 1161
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    TIGR01628
    Location:647 → 816
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd02337
    Location:1671 → 1711
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1173 → 1245
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1246 → 1280
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam09606
    Location:1995 → 2366
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02172
    Location:567 → 647
    KIX; KIX domain
    pfam02135
    Location:348 → 415
    zf-TAZ; TAZ zinc finger
    pfam03154
    Location:642 → 992
    Atrophin-1; Atrophin-1 family
    pfam08214
    Location:1309 → 1615
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1997 → 2101
    Creb_binding; Creb binding

  2. XM_038550447.1 → XP_038406375.1  histone acetyltransferase p300 isoform X2

    UniProtKB/TrEMBL
    A0A8C0PIR7, A0A8C0T1V5, A0A8I3P1J8
    Conserved Domains (10) summary
    cd05495
    Location:994 → 1101
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    TIGR01628
    Location:647 → 816
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd02337
    Location:1611 → 1651
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1113 → 1185
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1186 → 1220
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam09606
    Location:1935 → 2306
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02172
    Location:567 → 647
    KIX; KIX domain
    pfam02135
    Location:348 → 415
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1249 → 1555
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1937 → 2041
    Creb_binding; Creb binding

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    24010660..24090852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038638531.1 → XP_038494459.1  histone acetyltransferase p300 isoform X1

    UniProtKB/TrEMBL
    A0A8C0P7Y1, A0A8C0T224, A0A8I3P730
    Conserved Domains (11) summary
    cd05495
    Location:1054 → 1161
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    TIGR01628
    Location:647 → 816
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd02337
    Location:1671 → 1711
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1173 → 1245
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1246 → 1280
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam09606
    Location:1995 → 2366
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02172
    Location:567 → 647
    KIX; KIX domain
    pfam02135
    Location:348 → 415
    zf-TAZ; TAZ zinc finger
    pfam03154
    Location:642 → 992
    Atrophin-1; Atrophin-1 family
    pfam08214
    Location:1309 → 1615
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1997 → 2101
    Creb_binding; Creb binding

  2. XM_038638541.1 → XP_038494469.1  histone acetyltransferase p300 isoform X2

    UniProtKB/TrEMBL
    A0A8C0PIR7, A0A8C0T1V5, A0A8I3P1J8
    Conserved Domains (10) summary
    cd05495
    Location:994 → 1101
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    TIGR01628
    Location:647 → 816
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd02337
    Location:1611 → 1651
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    cd15802
    Location:1113 → 1185
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15646
    Location:1186 → 1220
    PHD_p300; PHD finger found in histone acetyltransferase p300
    pfam09606
    Location:1935 → 2306
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam02172
    Location:567 → 647
    KIX; KIX domain
    pfam02135
    Location:348 → 415
    zf-TAZ; TAZ zinc finger
    pfam08214
    Location:1249 → 1555
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1937 → 2041
    Creb_binding; Creb binding
Nucleotide Protein
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