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LDLR low density lipoprotein receptor [ Canis lupus familiaris (dog) ]

Gene ID: 100683160, updated on 8-Mar-2024

Summary

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Official Symbol
LDLRprovided by VGNC
Official Full Name
low density lipoprotein receptorprovided by VGNC
Primary source
VGNC:VGNC:42622
See related
Ensembl:ENSCAFG00845021826
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (50636154..50673474, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (49988705..50026032, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (50515859..50553174, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (49846492..49883796, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (50273144..50310479, complement)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111091379 Neighboring gene uncharacterized LOC119864742 Neighboring gene SPC24 component of NDC80 kinetochore complex Neighboring gene uncharacterized LOC119864744 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Neighboring gene uncharacterized LOC111091380 Neighboring gene translocase of inner mitochondrial membrane 29

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    50636154..50673474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038428592.1 → XP_038284520.1  low-density lipoprotein receptor

    UniProtKB/TrEMBL
    A0A8C0SX49, A0A8I3P953
    Related
    ENSCAFP00845030179.1, ENSCAFT00845038549.1
    Conserved Domains (5) summary
    smart00135
    Location:469 → 510
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:356 → 390
    EGF_CA; Calcium-binding EGF-like domain
    pfam00057
    Location:198 → 233
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:531 → 571
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:320 → 354
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    49846492..49883796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038504231.1 → XP_038360159.1  low-density lipoprotein receptor

    Conserved Domains (5) summary
    smart00135
    Location:555 → 597
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:356 → 390
    EGF_CA; Calcium-binding EGF-like domain
    pfam00057
    Location:198 → 233
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:531 → 571
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:320 → 354
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    50273144..50310479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038631409.1 → XP_038487337.1  low-density lipoprotein receptor

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    50515859..50553174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038567258.1 → XP_038423186.1  low-density lipoprotein receptor

    UniProtKB/TrEMBL
    A0A8C0SX49, A0A8I3P953
    Conserved Domains (5) summary
    smart00135
    Location:469 → 510
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:356 → 390
    EGF_CA; Calcium-binding EGF-like domain
    pfam00057
    Location:198 → 233
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:531 → 571
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:320 → 354
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    49988705..50026032 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005632869.4 → XP_005632926.1  low-density lipoprotein receptor

    UniProtKB/TrEMBL
    A0A8C0SX49, A0A8P0SLN2
    Conserved Domains (6) summary
    smart00135
    Location:469 → 510
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:356 → 390
    EGF_CA; Calcium-binding EGF-like domain
    pfam00057
    Location:198 → 233
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:531 → 571
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl00104
    Location:280 → 310
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam14670
    Location:320 → 354
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
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