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Mpc2 mitochondrial pyruvate carrier 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100359982, updated on 4-Jan-2025

Summary

Official Symbol
Mpc2provided by RGD
Official Full Name
mitochondrial pyruvate carrier 2provided by RGD
Primary source
RGD:1563422
See related
EnsemblRapid:ENSRNOG00000003150 AllianceGenome:RGD:1563422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Brp44; SLC54A2; RGD1563422
Summary
Predicted to enable identical protein binding activity and pyruvate transmembrane transporter activity. Predicted to be involved in mitochondrial pyruvate transmembrane transport. Predicted to act upstream of or within acetyl-CoA biosynthetic process from pyruvate and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 1056.6), Kidney (RPKM 874.2) and 9 other tissues See more
Orthologs
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Genomic context

See Mpc2 in Genome Data Viewer
Location:
13q23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80261143..80280668)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (77728176..77747664)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83680527..83700491)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 161 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene uncharacterized LOC134481587 Neighboring gene adenylate cyclase 10 Neighboring gene uncharacterized LOC134481588

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in mitochondrial inner membrane  
located_in mitochondrial inner membrane  
is_active_in mitochondrial inner membrane  
located_in mitochondrial inner membrane  
located_in mitochondrial inner membrane  
located_in mitochondrion  

General protein information

Preferred Names
mitochondrial pyruvate carrier 2
Names
brain protein 44
protein 0-44
solute carrier family 54 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077643.2NP_001071111.1  mitochondrial pyruvate carrier 2 isoform 1

    See identical proteins and their annotated locations for NP_001071111.1

    Status: VALIDATED

    Source sequence(s)
    FM061478, JAXUCZ010000013
    UniProtKB/Swiss-Prot
    P38718
    UniProtKB/TrEMBL
    A6IDH0
    Related
    ENSRNOP00000004206.6, ENSRNOT00000004206.9
    Conserved Domains (1) summary
    pfam03650
    Location:33122
    MPC; Uncharacterized protein family (UPF0041)
  2. NM_001322942.1NP_001309871.1  mitochondrial pyruvate carrier 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6AS07, A6IDG9
    Related
    ENSRNOP00000094616.1, ENSRNOT00000098110.2
    Conserved Domains (1) summary
    pfam03650
    Location:3381
    MPC; Uncharacterized protein family (UPF0041)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    80261143..80280668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250126.4XP_006250188.1  mitochondrial pyruvate carrier 2 isoform X1

    UniProtKB/Swiss-Prot
    P38718
    Conserved Domains (1) summary
    pfam03650
    Location:33114
    MPC; Uncharacterized protein family (UPF0041)
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