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cd44b CD44 molecule (IN blood group) b [ Danio rerio (zebrafish) ]

Gene ID: 100330801, updated on 27-Mar-2024

Summary

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Official Symbol
cd44bprovided by ZNC
Official Full Name
CD44 molecule (IN blood group) bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110429-2
See related
Ensembl:ENSDARG00000089892 AllianceGenome:ZFIN:ZDB-GENE-110429-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable hyaluronic acid binding activity and transmembrane signaling receptor activity. Predicted to contribute to cytokine receptor activity. Predicted to be involved in cell adhesion; inflammatory response; and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in membrane and microvillus. Predicted to be integral component of membrane. Predicted to be part of macrophage migration inhibitory factor receptor complex. Predicted to be active in basolateral plasma membrane. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 25
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (37408517..37422945, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (36837959..36852376, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene peptidase domain containing associated with muscle regeneration 1b Neighboring gene solute carrier family 1 member 2b Neighboring gene pyruvate dehydrogenase complex component X Neighboring gene charged multivesicular body protein 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Immunophenotypic characterization, multi-lineage differentiation and aging of zebrafish heart and liver tissue-derived mesenchymal stem cells as a novel approach in stem cell-based therapy. Fathi E, et al. Tissue Cell, 2019 Apr. PMID 30947959
  2. Extracellular component hyaluronic acid and its receptor Hmmr are required for epicardial EMT during heart regeneration. Missinato MA, et al. Cardiovasc Res, 2015 Sep 1. PMID 26156497, Free PMC Article
  3. Hyaluronic acid synthesis is required for zebrafish tail fin regeneration. Ouyang X, et al. PLoS One, 2017. PMID 28207787, Free PMC Article
  4. The negative regulation of piscine CD44c in viral and bacterial infection. Cao L, et al. Dev Comp Immunol, 2019 Jul. PMID 30885554
  5. Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Li Y, et al. Genes Dev, 2014 Dec 1. PMID 25395663, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hyaluronic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of macrophage migration inhibitory factor receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microvillus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CD44 antigen
Names
CD44 molecule (Indian blood group) b

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    37408517..37422945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017354304.2 → XP_017209793.1  CD44 antigen isoform X5

    UniProtKB/TrEMBL
    A0A8M6Z4J5

  2. XM_009298237.3 → XP_009296512.1  CD44 antigen isoform X2

    UniProtKB/TrEMBL
    A0A8M3APC4
    Conserved Domains (1) summary
    cl02612
    Location:70 → 219
    Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...

  3. XM_017354301.2 → XP_017209790.1  CD44 antigen isoform X1

    UniProtKB/TrEMBL
    A0A8M6YYL8

  4. XM_017354303.2 → XP_017209792.1  CD44 antigen isoform X4

    UniProtKB/TrEMBL
    A0A8M6YW61, X1WBP3
    Related
    ENSDARP00000127635.1, ENSDART00000156018.2

  5. XM_017354302.2 → XP_017209791.1  CD44 antigen isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z569
Nucleotide Protein
Heading Accession and Version

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