U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LRP5 LDL receptor related protein 5 [ Canis lupus familiaris (dog) ]

Gene ID: 100306933, updated on 8-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
LRP5provided by VGNC
Official Full Name
LDL receptor related protein 5provided by VGNC
Primary source
VGNC:VGNC:49918
See related
Ensembl:ENSCAFG00845007778
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 18
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (50355437..50463484, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (48048981..48156123, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (49942316..50049714, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (49575315..49682550, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (49149276..49256627, complement)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119864261 Neighboring gene galanin and GMAP prepropeptide Neighboring gene protein phosphatase 6 regulatory subunit 3 Neighboring gene chromosome 18 C11orf24 homolog Neighboring gene lysine methyltransferase 5B

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Wnt receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
low-density lipoprotein receptor-related protein 5
Names
low density lipoprotein receptor-related protein 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    50355437..50463484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038424758.1 → XP_038280686.1  low-density lipoprotein receptor-related protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MW87, A0A8P0NCW3
    Conserved Domains (7) summary
    smart00135
    Location:399 → 441
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1337 → 1371
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:711 → 747
    NHL; NHL repeat [structural motif]
    cl18310
    Location:676 → 869
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1249 → 1286
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:154 → 194
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:290 → 327
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_038424759.1 → XP_038280687.1  low-density lipoprotein receptor-related protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8C0P854, A0A8C0QTW6, A0A8I3MW87, A0A8P0NCW3
    Related
    ENSCAFP00845010656.1, ENSCAFT00845013723.1
    Conserved Domains (7) summary
    smart00135
    Location:399 → 441
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1327 → 1361
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:711 → 747
    NHL; NHL repeat [structural motif]
    cl18310
    Location:676 → 869
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1249 → 1286
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:154 → 194
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:290 → 327
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    49575315..49682550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038501015.1 → XP_038356943.1  low-density lipoprotein receptor-related protein 5 isoform X1

    Conserved Domains (7) summary
    smart00135
    Location:399 → 441
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1337 → 1371
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:711 → 747
    NHL; NHL repeat [structural motif]
    cl18310
    Location:676 → 869
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1249 → 1286
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:154 → 194
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:290 → 327
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_038501016.1 → XP_038356944.1  low-density lipoprotein receptor-related protein 5 isoform X2

    Conserved Domains (7) summary
    smart00135
    Location:399 → 441
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1327 → 1361
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:711 → 747
    NHL; NHL repeat [structural motif]
    cl18310
    Location:676 → 869
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1249 → 1286
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:154 → 194
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:290 → 327
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    49149276..49256627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038627817.1 → XP_038483745.1  low-density lipoprotein receptor-related protein 5 isoform X1

    Conserved Domains (7) summary
    smart00135
    Location:399 → 441
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1337 → 1371
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:711 → 747
    NHL; NHL repeat [structural motif]
    cl18310
    Location:676 → 869
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1249 → 1286
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:154 → 194
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:290 → 327
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_038627818.1 → XP_038483746.1  low-density lipoprotein receptor-related protein 5 isoform X2

    Conserved Domains (7) summary
    smart00135
    Location:399 → 441
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1327 → 1361
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:711 → 747
    NHL; NHL repeat [structural motif]
    cl18310
    Location:676 → 869
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1249 → 1286
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:154 → 194
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:290 → 327
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    49942316..50049714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038563697.1 → XP_038419625.1  low-density lipoprotein receptor-related protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MW87, A0A8P0NCW3
    Conserved Domains (7) summary
    smart00135
    Location:399 → 441
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1337 → 1371
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:711 → 747
    NHL; NHL repeat [structural motif]
    cl18310
    Location:676 → 869
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1249 → 1286
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:154 → 194
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:290 → 327
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_038563698.1 → XP_038419626.1  low-density lipoprotein receptor-related protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8C0P854, A0A8C0QTW6, A0A8I3MW87, A0A8P0NCW3
    Conserved Domains (7) summary
    smart00135
    Location:399 → 441
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1327 → 1361
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:711 → 747
    NHL; NHL repeat [structural motif]
    cl18310
    Location:676 → 869
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1249 → 1286
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:154 → 194
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:290 → 327
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    48048981..48156123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038453948.1 → XP_038309876.1  low-density lipoprotein receptor-related protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MW87, A0A8P0NCW3
    Conserved Domains (7) summary
    smart00135
    Location:399 → 441
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1337 → 1371
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:711 → 747
    NHL; NHL repeat [structural motif]
    cl18310
    Location:676 → 869
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1249 → 1286
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:154 → 194
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:290 → 327
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_038453949.1 → XP_038309877.1  low-density lipoprotein receptor-related protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8C0P854, A0A8C0QTW6, A0A8I3MW87, A0A8P0NCW3
    Conserved Domains (7) summary
    smart00135
    Location:399 → 441
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1327 → 1361
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:711 → 747
    NHL; NHL repeat [structural motif]
    cl18310
    Location:676 → 869
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00057
    Location:1249 → 1286
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:154 → 194
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:290 → 327
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.