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HRAS HRas proto-oncogene, GTPase [ Bos taurus (cattle) ]

Gene ID: 100298939, updated on 8-Mar-2024

Summary

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Official Symbol
HRASprovided by VGNC
Official Full Name
HRas proto-oncogene, GTPaseprovided by VGNC
Primary source
VGNC:VGNC:29951
See related
Ensembl:ENSBTAG00000046644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
H-Ras
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 29
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (50762262..50765201)

Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene Ras association domain family member 7 Neighboring gene lamin tail domain containing 2 Neighboring gene leucine rich repeat containing 56 Neighboring gene uncharacterized LOC112444926 Neighboring gene ribonuclease/angiogenin inhibitor 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Increased oxidative stress in diabetes regulates activation of a small molecular weight G-protein, H-Ras, in the retina. Kowluru V, et al. Mol Vis, 2007 Apr 19. PMID 17515880, Free PMC Article
  2. Small molecular weight G-protein, H-Ras, and retinal endothelial cell apoptosis in diabetes. Kowluru RA, et al. Mol Cell Biochem, 2007 Feb. PMID 16924412
  3. H-ras immunohistochemical expression and molecular analysis of urinary bladder lesions in grazing adult cattle exposed to bracken fern. Sardon D, et al. J Comp Pathol, 2005 Feb-Apr. PMID 15737346
  4. Mechanism of bracken fern carcinogenesis: evidence for H-ras activation via initial adenine alkylation by ptaquiloside. Prakash AS, et al. Nat Toxins, 1996. PMID 8946397
  5. Multiple Harvey-ras genes in the bovine genome. McCaffery RE, et al. Oncogene, 1989 Dec. PMID 2687766

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thrombospondin 1, fibronectin, and vitronectin are differentially dependent upon RAS, ERK1/2, and p38 for induction of vascular smooth muscle cell chemotaxis.
    Title: Thrombospondin 1, fibronectin, and vitronectin are differentially dependent upon RAS, ERK1/2, and p38 for induction of vascular smooth muscle cell chemotaxis.
  2. Activation of H-Ras and its downstream signaling pathway in the retina and its vasculature could be under the control of superoxide, and H-Ras activation in diabetes can be prevented by inhibiting superoxide accumulation.
    Title: Increased oxidative stress in diabetes regulates activation of a small molecular weight G-protein, H-Ras, in the retina.
  3. Data demonstrate that H-Ras activation is important in the activation of the specific signaling events leading to the accelerated retinal capillary cell apoptosis in hyperglycemic conditions.
    Title: Small molecular weight G-protein, H-Ras, and retinal endothelial cell apoptosis in diabetes.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GDP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular senescence IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
GTPase HRas
Names
GTPase HRas (Transforming protein p21) (H-Ras-1) (c-H-ras)
Harvey ras 1
p19 H-RasIDX protein
v-Ha-ras Harvey rat sarcoma viral oncogene homolog
NP_001229275.1
NP_001229276.1
XP_059738730.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242346.1 → NP_001229275.1  GTPase HRas isoform 1

    See identical proteins and their annotated locations for NP_001229275.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    CB419631, CO892114, DN532777
    UniProtKB/TrEMBL
    G3MXH2
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  2. NM_001242347.1 → NP_001229276.1  GTPase HRas isoform 2

    See identical proteins and their annotated locations for NP_001229276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    CB419631, CO892114, DY123658
    UniProtKB/TrEMBL
    A0A3Q1LKB7, G3N1U2
    Related
    ENSBTAP00000055845.2, ENSBTAT00000064149.2
    Conserved Domains (1) summary
    cd04138
    Location:3 → 150
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    50762262..50765201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059882747.1 → XP_059738730.1  GTPase HRas isoform X1

    UniProtKB/TrEMBL
    G3MXH2
Nucleotide Protein Strain
Heading Accession and Version

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