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PSMD4 proteasome 26S subunit ubiquitin receptor, non-ATPase 4 [ Canis lupus familiaris (dog) ]

Gene ID: 100192385, updated on 8-Mar-2024

Summary

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Official Symbol
PSMD4provided by VGNC
Official Full Name
proteasome 26S subunit ubiquitin receptor, non-ATPase 4provided by VGNC
Primary source
VGNC:VGNC:45113
See related
Ensembl:ENSCAFG00845022451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (61322307..61329783)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (59749765..59757144)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (60964850..60972228)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (60151041..60158407)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (60236561..60243942)

Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 72 homolog Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 alpha Neighboring gene uncharacterized LOC119863995 Neighboring gene zinc finger protein 687 Neighboring gene uncharacterized LOC119863994 Neighboring gene phosphatidylinositol 4-kinase beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of proteasome regulatory particle, base subcomplex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 4
Names
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
proteasome 26S subunit, non-ATPase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136564.2 → NP_001130036.1  26S proteasome non-ATPase regulatory subunit 4

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000359
    UniProtKB/TrEMBL
    A0A8C0KJH1, A0A8C0RFH5
    Conserved Domains (2) summary
    cd01452
    Location:1 → 187
    VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
    cd22297
    Location:320 → 363
    PSMD4_RAZUL; RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051821.1 Reference ROS_Cfam_1.0

    Range
    61322307..61329783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038690407.1 → XP_038546335.1  26S proteasome non-ATPase regulatory subunit 4 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PB85, A0A8P0NEH6
    Related
    ENSCAFP00845031050.1, ENSCAFT00845039636.1
    Conserved Domains (2) summary
    cd01452
    Location:1 → 198
    VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
    cd22297
    Location:331 → 374
    PSMD4_RAZUL; RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins

  2. XM_038690405.1 → XP_038546333.1  26S proteasome non-ATPase regulatory subunit 4 isoform X1

    Conserved Domains (2) summary
    cd01452
    Location:29 → 217
    VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
    cd22297
    Location:350 → 393
    PSMD4_RAZUL; RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins

  3. XM_038690406.1 → XP_038546334.1  26S proteasome non-ATPase regulatory subunit 4 isoform X2

    Conserved Domains (2) summary
    cd01452
    Location:29 → 206
    VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
    cd22297
    Location:339 → 382
    PSMD4_RAZUL; RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins

  4. XM_038690409.1 → XP_038546337.1  26S proteasome non-ATPase regulatory subunit 4 isoform X4

    Conserved Domains (2) summary
    cd01452
    Location:1 → 183
    VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
    cd22297
    Location:316 → 359
    PSMD4_RAZUL; RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins

  5. XM_038690411.1 → XP_038546339.1  26S proteasome non-ATPase regulatory subunit 4 isoform X4

    Conserved Domains (2) summary
    cd01452
    Location:1 → 183
    VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
    cd22297
    Location:316 → 359
    PSMD4_RAZUL; RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins

  6. XM_038690408.1 → XP_038546336.1  26S proteasome non-ATPase regulatory subunit 4 isoform X4

    Conserved Domains (2) summary
    cd01452
    Location:1 → 183
    VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
    cd22297
    Location:316 → 359
    PSMD4_RAZUL; RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins

  7. XM_038690410.1 → XP_038546338.1  26S proteasome non-ATPase regulatory subunit 4 isoform X4

    Conserved Domains (2) summary
    cd01452
    Location:1 → 183
    VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
    cd22297
    Location:316 → 359
    PSMD4_RAZUL; RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049277.1 Alternate UMICH_Zoey_3.1

    Range
    60151041..60158407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

    Range
    60236561..60243942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

    Range
    60964850..60972228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    59749765..59757144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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