itgav integrin, alpha V [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: itgavprovided by ZNC
Official Full Name: integrin, alpha Vprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060616-382
See related: Ensembl:ENSDARG00000006314 AllianceGenome:ZFIN:ZDB-GENE-060616-382
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:136222
Summary: Acts upstream of or within several processes, including Kupffer's vesicle development; axis elongation involved in somitogenesis; and endothelial cell proliferation. Part of integrin complex. Is expressed in several structures, including axis; diencephalon; head; pleuroperitoneal region; and post-vent vasculature. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Orthologous to human ITGAV (integrin subunit alpha V). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (11597500..11654996, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (11626297..11683793, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

integrin alphav regulates VANGL2 protein levels
Title: VANGL2 protein stability is regulated by integrin αv and the extracellular matrix.
Data suggest that a complex involving betaPix, GIT1 and integrin alpha(v)beta(8) may regulate vascular stability, cerebral angiogenesis and endothelial cell proliferation in the developing embryo.
Title: βPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin αvβ8.
Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry.
Title: Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry.
beta3.1 is the major beta3 paralog that associates with alphaV in zebrafish; pharyngeal dentitions appear to represent a unique expression field for alphaV and beta3.
Title: The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axis elongation involved in somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endoderm formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endothelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pharyngeal system development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin alpha-V

Names: vitronectin receptor, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033721.1 → NP_001028893.1 integrin alpha-V precursor

See identical proteins and their annotated locations for NP_001028893.1

Status: PROVISIONAL

Source sequence(s)

DQ178648

UniProtKB/TrEMBL

Q3LTM3

Related

ENSDARP00000044313.6, ENSDART00000044314.8

Conserved Domains (3) summary

smart00191
Location:297 → 345

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:463 → 911

Integrin_alpha2; Integrin alpha

pfam13517
Location:255 → 320

VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella