lepa leptin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lepaprovided by ZNC
Official Full Name: leptin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-081001-1
See related: Ensembl:ENSDARG00000091085 AllianceGenome:ZFIN:ZDB-GENE-081001-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ob; lep; ob-a; si:dkey-98o11.2
Summary: Predicted to enable hormone activity. Acts upstream of or within camera-type eye development; inner ear development; and nervous system development. Predicted to be located in extracellular region. Is expressed in several structures, including brain; digestive system; heart; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human LEP (leptin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 18

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (10686714..10690381)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (10719498..10721679)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leptin mutation and mycobacterial infection lead non-synergistically to a similar metabolic syndrome.
Title: Leptin mutation and mycobacterial infection lead non-synergistically to a similar metabolic syndrome.
Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish.
Title: Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish.
the lepr mutant background had a higher survival rate and significantly lower muscle-wasting level after tumor induction than the tumor fish in the wild-type background.
Title: Leptin induces muscle wasting in a zebrafish kras-driven hepatocellular carcinoma (HCC) model.
Results provide strong evidence for a critical role of lepa gene in modulating anxiety, aggression, fear, and circadian rhythm behaviors in zebrafish.
Title: Zebrafish Mutants Carrying Leptin a (lepa) Gene Deficiency Display Obesity, Anxiety, Less Aggression and Fear, and Circadian Rhythm and Color Preference Dysregulation.
High leptin expression is associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors.
Title: Vascular Endothelial Growth Factor A and Leptin Expression Associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors.
CRISPR mutagenesis of lepa, but not lepb, exhibited increased beta-cell number. An increase in beta-cell number in F2 sibling larvae mutant for lepa independently supported the role of lepa in the islet phenotype.
Title: Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish.
The finding of duplicate leptin genes in teleosts adds to our understanding of the evolution of leptin physiology in the early vertebrate lineage.
Title: Two divergent leptin paralogues in zebrafish (Danio rerio) that originate early in teleostean evolution.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: leptin a; leptin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.