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chrm3b cholinergic receptor, muscarinic 3b [ Danio rerio (zebrafish) ]

Gene ID: 100149598, updated on 11-Apr-2024

Summary

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Official Symbol
chrm3bprovided by ZNC
Official Full Name
cholinergic receptor, muscarinic 3bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090410-5
See related
Ensembl:ENSDARG00000071298 AllianceGenome:ZFIN:ZDB-GENE-090410-5
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable G protein-coupled acetylcholine receptor activity and G protein-coupled serotonin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; chemical synaptic transmission; and regulation of vascular associated smooth muscle contraction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in postsynaptic membrane. Predicted to be integral component of membrane. Predicted to be active in dendrite and synapse. Predicted to be integral component of plasma membrane. Is expressed in eye. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 12
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (47429417..47430918)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (47431576..47433060)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase Neighboring gene ryanodine receptor 2a (cardiac) Neighboring gene formin 2b Neighboring gene gremlin 2, DAN family BMP antagonist b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pharmaceutical Assessment Suggests Locomotion Hyperactivity in Zebrafish Triggered by Arecoline Might Be Associated with Multiple Muscarinic Acetylcholine Receptors Activation. Siregar P, et al. Toxins (Basel), 2021 Apr 3. PMID 33916832, Free PMC Article
  2. Developmental expression of muscarinic receptors in the eyes of zebrafish. Nuckels RJ, et al. Brain Res, 2011 Aug 8. PMID 21741623
  3. Evolution of the Muscarinic Acetylcholine Receptors in Vertebrates. Pedersen JE, et al. eNeuro, 2018 Sep-Oct. PMID 30564629, Free PMC Article
  4. Cloning and characterization of muscarinic receptor genes from the nile tilapia (Oreochromis niloticus). Seo JS, et al. Mol Cells, 2009 Mar 31. PMID 19326086
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled acetylcholine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
muscarinic acetylcholine receptor M3-like
Names
DrM3B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    47429417..47430918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001919125.2 → XP_001919160.1  muscarinic acetylcholine receptor M3-like

    UniProtKB/TrEMBL
    A0A8M1QL11, U3JAM0
    Related
    ENSDARP00000127288.1, ENSDART00000153015.2
    Conserved Domains (2) summary
    pfam00001
    Location:79 → 448
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:72 → 244
    7tm_4; Olfactory receptor
Nucleotide Protein
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