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polr2b RNA polymerase II subunit B [ Danio rerio (zebrafish) ]

Gene ID: 100149268, updated on 27-Mar-2024

Summary

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Official Symbol
polr2bprovided by ZNC
Official Full Name
RNA polymerase II subunit Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041008-1
See related
Ensembl:ENSDARG00000098783 AllianceGenome:ZFIN:ZDB-GENE-041008-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:109952
Summary
Predicted to enable several functions, including DNA binding activity; metal ion binding activity; and ribonucleoside binding activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Predicted to act upstream of or within transcription, DNA-templated. Predicted to be part of RNA polymerase II, core complex. Orthologous to human POLR2B (RNA polymerase II subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See polr2b in Genome Data Viewer
Location:
chromosome: 14
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (52380424..52408402, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (51664730..51692708, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase assembly factor COX18 Neighboring gene insulin-like growth factor binding protein 7 Neighboring gene nitric oxide associated 1 Neighboring gene RE1-silencing transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis. García-Castillo J, et al. Proc Natl Acad Sci U S A, 2021 Aug 10. PMID 34353901, Free PMC Article
  2. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
  3. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis.
    Title: Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase II activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase II subunit RPB2
Names
polymerase (RNA) II (DNA directed) polypeptide B
NP_001019632.2
XP_017214461.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024461.3 → NP_001019632.2  DNA-directed RNA polymerase II subunit RPB2

    See identical proteins and their annotated locations for NP_001019632.2

    Status: VALIDATED

    Source sequence(s)
    AL954718, CABZ01048449, CABZ01048450, CABZ01048451
    UniProtKB/TrEMBL
    A0A0R4IXL0, A0A8M1N6S0
    Related
    ENSDARP00000142035.1, ENSDART00000167045.3
    Conserved Domains (4) summary
    PRK08565
    Location:27 → 1172
    PRK08565; DNA-directed RNA polymerase subunit B; Provisional
    cd00653
    Location:39 → 1172
    RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
    pfam04566
    Location:567 → 629
    RNA_pol_Rpb2_4; RNA polymerase Rpb2, domain 4
    pfam04567
    Location:653 → 700
    RNA_pol_Rpb2_5; RNA polymerase Rpb2, domain 5

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    52380424..52408402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358972.2 → XP_017214461.1  DNA-directed RNA polymerase II subunit RPB2 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IXL0, A0A8M1N6S0
    Conserved Domains (4) summary
    PRK08565
    Location:27 → 1172
    PRK08565; DNA-directed RNA polymerase subunit B; Provisional
    cd00653
    Location:39 → 1172
    RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
    pfam04566
    Location:567 → 629
    RNA_pol_Rpb2_4; RNA polymerase Rpb2, domain 4
    pfam04567
    Location:653 → 700
    RNA_pol_Rpb2_5; RNA polymerase Rpb2, domain 5
Nucleotide Protein Strain
Heading Accession and Version

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