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STAT6 signal transducer and activator of transcription 6 [ Canis lupus familiaris (dog) ]

Gene ID: 100142679, updated on 11-Apr-2024

Summary

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Official Symbol
STAT6provided by VGNC
Official Full Name
signal transducer and activator of transcription 6provided by VGNC
Primary source
VGNC:VGNC:46892
See related
Ensembl:ENSCAFG00845009828
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
24
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (1243003..1257485, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (1297560..1307021, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (1587736..1597208, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (1220880..1230352, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (1462887..1472341, complement)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene myosin IA Neighboring gene nuclear envelope integral membrane protein 1 Neighboring gene NGFI-A binding protein 2 Neighboring gene uncharacterized LOC119873570 Neighboring gene LDL receptor related protein 1 Neighboring gene neurexophilin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of canine interleukin-4 in canine chondrocytes inhibits inflammatory cascade through STAT6. Rachakonda PS, et al. Cytokine, 2008 Oct. PMID 18789870

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
signal transducer and activator of transcription 6
Names
signal transducer and activator of transcription 6, interleukin-4 induced

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001314102.1 → NP_001301031.1  signal transducer and activator of transcription 6

    Status: PROVISIONAL

    Source sequence(s)
    BK006461
    UniProtKB/TrEMBL
    A0A0I9QQS7, A0A8C0S748, A0A8P0T0S2
    Related
    ENSCAFP00845013647.1, ENSCAFT00845017535.1
    Conserved Domains (5) summary
    cd10377
    Location:489 → 618
    SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
    pfam01017
    Location:96 → 243
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:245 → 498
    STAT_bind; STAT protein, DNA binding domain
    pfam14596
    Location:627 → 816
    STAT6_C; STAT6 C-terminal
    cl03749
    Location:2 → 122
    STAT_int; STAT protein, protein interaction domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    1243003..1257485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038678723.1 → XP_038534651.1  signal transducer and activator of transcription 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LK67, A0A8C0S748
    Related
    ENSCAFP00845013516.1, ENSCAFT00845017354.1
    Conserved Domains (5) summary
    cd10377
    Location:517 → 646
    SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
    smart00964
    Location:2 → 115
    STAT_int; STAT protein, protein interaction domain
    pfam14596
    Location:655 → 844
    STAT6_C; STAT6 C-terminal
    cd16856
    Location:105 → 276
    STAT6_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 6 (STAT6)
    cd16850
    Location:273 → 432
    STAT6_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 6 (STAT6)

  2. XM_038678722.1 → XP_038534650.1  signal transducer and activator of transcription 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LK67, A0A8C0S748
    Conserved Domains (5) summary
    cd10377
    Location:517 → 646
    SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
    smart00964
    Location:2 → 115
    STAT_int; STAT protein, protein interaction domain
    pfam14596
    Location:655 → 844
    STAT6_C; STAT6 C-terminal
    cd16856
    Location:105 → 276
    STAT6_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 6 (STAT6)
    cd16850
    Location:273 → 432
    STAT6_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 6 (STAT6)

  3. XM_038678721.1 → XP_038534649.1  signal transducer and activator of transcription 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LK67, A0A8C0S748
    Conserved Domains (5) summary
    cd10377
    Location:517 → 646
    SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
    smart00964
    Location:2 → 115
    STAT_int; STAT protein, protein interaction domain
    pfam14596
    Location:655 → 844
    STAT6_C; STAT6 C-terminal
    cd16856
    Location:105 → 276
    STAT6_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 6 (STAT6)
    cd16850
    Location:273 → 432
    STAT6_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 6 (STAT6)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    1220880..1230352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    1462887..1472341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    1587736..1597208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    1297560..1307021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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