PLA2G4B phospholipase A2 group IVB [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLA2G4Bprovided by HGNC
Official Full Name: phospholipase A2 group IVBprovided by HGNC
Primary source: HGNC:HGNC:9036
See related: Ensembl:ENSG00000243708 MIM:606088; AllianceGenome:HGNC:9036
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HsT16992; cPLA2-beta
Summary: This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in skin (RPKM 29.6), esophagus (RPKM 11.9) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q15.1

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (41838847..41848143)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (39644798..39654098)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (42131045..42140341)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JMJD7-PLA2G4B may serve as an important therapeutic target and prognostic marker for head and neck squamous cell carcinoma development and progression.
Title: A novel read-through transcript JMJD7-PLA2G4B regulates head and neck squamous cell carcinoma cell proliferation and survival.
TLR2 cooperates with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses
Title: Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH91785 (e-PCR)
- UniSTS:86288

D15S711E (e-PCR)
- UniSTS:151613

WI-13757 (e-PCR)
- UniSTS:20082

D1S1423 (e-PCR)
- UniSTS:149619

SHGC-58472 (e-PCR)
- UniSTS:94355

RH102897 (e-PCR)
- UniSTS:97231

D5S1597E (e-PCR)
- UniSTS:151019

Readthrough JMJD7-PLA2G4B

Readthrough gene: JMJD7-PLA2G4B, Included gene: JMJD7

Clone Names

FLJ17693, FLJ42498, FLJ53173, DKFZp686N12131

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	NAS Non-traceable Author Statement more info	PubMed
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	NAS Non-traceable Author Statement more info	PubMed
enables lysophospholipase activity	NAS Non-traceable Author Statement more info	PubMed
enables phosphatidyl phospholipase B activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	TAS Traceable Author Statement more info
enables phospholipase A2 activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in calcium-mediated signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in glycerophospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerophospholipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	NAS Non-traceable Author Statement more info	PubMed
involved_in parturition	NAS Non-traceable Author Statement more info	PubMed
involved_in phosphatidylglycerol acyl-chain remodeling	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cytosolic phospholipase A2 beta

Names: lysophospholipase A1 group IVB; phospholipase A2, group IVB (cytosolic)

NP_001108105.1

EC 3.1.1.4

EC 3.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114633.2 → NP_001108105.1 cytosolic phospholipase A2 beta

See identical proteins and their annotated locations for NP_001108105.1

Status: VALIDATED

Source sequence(s)

AK310651, BF372565, BM982475, CA488226, CU447449, DA250544

Consensus CDS

CCDS45241.1

UniProtKB/Swiss-Prot

B4DRT9, P0C869, Q19KD5, Q19KD6

Related

ENSP00000416610.1, ENST00000458483.4

Conserved Domains (3) summary

cd07201
Location:243 → 768

cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent

cd04036
Location:11 → 130

C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

pfam18695
Location:151 → 242

cPLA2_C2; Cytosolic phospholipases A2 C2-domain