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Ccl27al C-C motif chemokine ligand 27A like [ Mus musculus (house mouse) ]

Gene ID: 100039863, updated on 8-Feb-2024

Summary

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Official Symbol
Ccl27alprovided by MGI
Official Full Name
C-C motif chemokine ligand 27A likeprovided by MGI
Primary source
MGI:MGI:3713752
See related
Ensembl:ENSMUSG00000073877 AllianceGenome:MGI:3713752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm2506; Gm13306; 100039939
Summary
Is expressed in hip; sensory organ; and skeleton. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 30.8), testis adult (RPKM 20.9) and 15 other tissues See more
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Genomic context

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Location:
4 A5; 4 22.29 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (42153404..42158846)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (42153404..42158846)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 21F Neighboring gene C-C motif chemokine ligand 19, pseudogene 3 Neighboring gene interleukin 11 receptor subunit alpha 3 Neighboring gene predicted gene, 53181 Neighboring gene C-C motif chemokine ligand 21B (leucine) Neighboring gene STARR-seq mESC enhancer starr_10038 Neighboring gene STARR-seq mESC enhancer starr_10039 Neighboring gene STARR-seq mESC enhancer starr_10040 Neighboring gene family with sequence similarity 205 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues. Davila ML, et al. iScience, 2022 Jun 17. PMID 35663027, Free PMC Article
  2. The chemokine ESkine/CCL27 displays novel modes of intracrine and paracrine function. Gortz A, et al. J Immunol, 2002 Aug 1. PMID 12133963
  3. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Morales J, et al. Proc Natl Acad Sci U S A, 1999 Dec 7. PMID 10588729, Free PMC Article
  4. ESkine, a novel beta-chemokine, is differentially spliced to produce secretable and nuclear targeted isoforms. Baird JW, et al. J Biol Chem, 1999 Nov 19. PMID 10559234
  5. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. Ishikawa-Mochizuki I, et al. FEBS Lett, 1999 Nov 5. PMID 10556532

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC41145

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CCR3 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in killing of cells of another organism ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
chemokine (C-C motif) ligand 27b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164046.1 → NP_001157518.1  chemokine (C-C motif) ligand 27b isoform 2 precursor

    See identical proteins and their annotated locations for NP_001157518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK005520, BY613083, BY652838
    Consensus CDS
    CCDS51149.1
    UniProtKB/Swiss-Prot
    Q3KNL1, Q9DAU6, Q9DAZ4, Q9Z1X0
    UniProtKB/TrEMBL
    A2AMS5
    Related
    ENSMUSP00000095726.3, ENSMUST00000098122.3
    Conserved Domains (1) summary
    cl00134
    Location:34 → 83
    Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

  2. NM_001199962.1 → NP_001186891.1  chemokine (C-C motif) ligand 27b isoform 1

    See identical proteins and their annotated locations for NP_001186891.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL824709, BY279294
    Consensus CDS
    CCDS57270.1
    UniProtKB/Swiss-Prot
    Q9Z1X0
    Related
    ENSMUSP00000103653.3, ENSMUST00000108018.9
    Conserved Domains (1) summary
    cl00134
    Location:49 → 98
    Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

  3. NM_001199963.1 → NP_001186892.1  chemokine (C-C motif) ligand 27b isoform 3

    See identical proteins and their annotated locations for NP_001186892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AL824709, BM119446
    Conserved Domains (1) summary
    pfam00048
    Location:39 → 99
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  4. NM_001384256.1 → NP_001371185.1  chemokine (C-C motif) ligand 27b isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL824709
    Conserved Domains (1) summary
    pfam00048
    Location:72 → 132
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  5. NM_001384257.1 → NP_001371186.1  chemokine (C-C motif) ligand 27b isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL824709
    Conserved Domains (1) summary
    pfam00048
    Location:92 → 152
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  6. NM_001384258.1 → NP_001371187.1  chemokine (C-C motif) ligand 27b isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL824709
    Conserved Domains (1) summary
    pfam00048
    Location:39 → 99
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    42153404..42158846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163516.1 → XP_036019409.1  chemokine (C-C motif) ligand 27b isoform X1

    Conserved Domains (1) summary
    pfam00048
    Location:94 → 154
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  2. XM_036163517.1 → XP_036019410.1  chemokine (C-C motif) ligand 27b isoform X2

    Conserved Domains (1) summary
    pfam00048
    Location:74 → 134
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  3. XM_036163518.1 → XP_036019411.1  chemokine (C-C motif) ligand 27b isoform X3

    Conserved Domains (1) summary
    pfam00048
    Location:39 → 99
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  4. XM_036163519.1 → XP_036019412.1  chemokine (C-C motif) ligand 27b isoform X3

    Conserved Domains (1) summary
    pfam00048
    Location:39 → 99
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  5. XM_006537497.2 → XP_006537560.1  chemokine (C-C motif) ligand 27b isoform X3

    See identical proteins and their annotated locations for XP_006537560.1

    Conserved Domains (1) summary
    pfam00048
    Location:39 → 99
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  6. XM_017319875.3 → XP_017175364.1  chemokine (C-C motif) ligand 27b isoform X3

    Conserved Domains (1) summary
    pfam00048
    Location:39 → 99
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

RNA

  1. XR_004941786.1 RNA Sequence

  2. XR_004941787.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001199964.1: Suppressed sequence

    Description
    NM_001199964.1: This RefSeq was permanently suppressed because this transcript variant is unsupported for this gene copy at the annotated genomic location on NCBI's Build 38.1.
Nucleotide Protein Strain
Heading Accession and Version

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