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htr5aa 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate a [ Danio rerio (zebrafish) ]

Gene ID: 100038775, updated on 11-Apr-2024

Summary

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Official Symbol
htr5aaprovided by ZNC
Official Full Name
5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060531-129
See related
Ensembl:ENSDARG00000038869 AllianceGenome:ZFIN:ZDB-GENE-060531-129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
htr5a; si:dkey-265a7.5
Summary
Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and chemical synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in brain; inferior raphe nucleus; and optic tectum. Orthologous to human HTR5A (5-hydroxytryptamine receptor 5A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 2
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (29925677..29938980)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (29942144..29955447)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:ch211-207d6.2 Neighboring gene PAX interacting (with transcription-activation domain) protein 1 Neighboring gene engrailed homeobox 2b Neighboring gene canopy FGF signaling regulator 1 Neighboring gene RNA binding motif protein 33b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Risk of prenatal depression and stress treatment: alteration on serotonin system of offspring through exposure to Fluoxetine. Pei S, et al. Sci Rep, 2016 Oct 5. PMID 27703173, Free PMC Article
  2. Cadmium chloride-induced transgenerational neurotoxicity in zebrafish development. Tian J, et al. Environ Toxicol Pharmacol, 2021 Jan. PMID 33171223
  3. Serotonin Promotes Development and Regeneration of Spinal Motor Neurons in Zebrafish. Barreiro-Iglesias A, et al. Cell Rep, 2015 Nov 3. PMID 26565906, Free PMC Article
  4. Developmental toxicity and neurotoxicity of penconazole enantiomers exposure on zebrafish (Danio rerio). Jia M, et al. Environ Pollut, 2020 Dec. PMID 32892009
  5. Parental transfer of microcystin-LR induced transgenerational effects of developmental neurotoxicity in zebrafish offspring. Wu Q, et al. Environ Pollut, 2017 Dec. PMID 28837927

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126410.2 → NP_001119882.2  5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate a

    Status: VALIDATED

    Source sequence(s)
    BX510360, CR855328
    UniProtKB/TrEMBL
    A0A0R4IFY3, A0A8M1NJ85
    Related
    ENSDARP00000151006.1, ENSDART00000180738.1
    Conserved Domains (1) summary
    pfam00001
    Location:45 → 326
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    29925677..29938980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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