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map2k5 mitogen-activated protein kinase kinase 5 [ Danio rerio (zebrafish) ]

Gene ID: 100007679, updated on 27-Mar-2024

Summary

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Official Symbol
map2k5provided by ZNC
Official Full Name
mitogen-activated protein kinase kinase 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1517
See related
Ensembl:ENSDARG00000011851 AllianceGenome:ZFIN:ZDB-GENE-030131-1517
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb73f02; wu:fb73f02; zgc:172137
Summary
Predicted to enable MAP kinase kinase activity. Acts upstream of or within brain development. Is expressed in spinal cord. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (33970693..34062555, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (33699550..33791331, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene protein inhibitor of activated STAT, 1a Neighboring gene SKI family transcriptional corepressor 1a Neighboring gene SMAD family member 3a Neighboring gene SMAD family member 6a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome. Schulte EC, et al. Am J Hum Genet, 2014 Jul 3. PMID 24995868, Free PMC Article
  2. Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target. Jo M, et al. Genome Res, 2017 Sep. PMID 28596290, Free PMC Article
  3. Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. Chou CM, et al. J Biomed Sci, 2015 Nov 17. PMID 26572230, Free PMC Article
  4. A genome-wide map of circular RNAs in adult zebrafish. Sharma D, et al. Sci Rep, 2019 Mar 5. PMID 30837568, Free PMC Article
  5. Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish. McGrail M, et al. PLoS One, 2011 Apr 21. PMID 21533036, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC172137

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dual specificity mitogen-activated protein kinase kinase 5
NP_001107789.1
XP_005168897.1
XP_009301481.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114317.1 → NP_001107789.1  dual specificity mitogen-activated protein kinase kinase 5

    See identical proteins and their annotated locations for NP_001107789.1

    Status: PROVISIONAL

    Source sequence(s)
    BC155612
    UniProtKB/TrEMBL
    A0A8M1NFG7, A9JRD0
    Related
    ENSDARP00000052403.4, ENSDART00000052404.6
    Conserved Domains (3) summary
    cd06395
    Location:17 → 106
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cd06619
    Location:164 → 442
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
    smart00220
    Location:170 → 419
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    33970693..34062555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168840.4 → XP_005168897.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X1

    See identical proteins and their annotated locations for XP_005168897.1

    UniProtKB/TrEMBL
    B1NA67
    Conserved Domains (3) summary
    cd06395
    Location:17 → 106
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cd06619
    Location:163 → 441
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
    smart00220
    Location:169 → 418
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  2. XM_009303206.3 → XP_009301481.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X2

    UniProtKB/TrEMBL
    A0A8M3BB07
    Conserved Domains (3) summary
    cd06619
    Location:114 → 392
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
    smart00220
    Location:120 → 369
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02720
    Location:1 → 56
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394698.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    5116..20511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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