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il6st interleukin 6 cytokine family signal transduce [ Danio rerio (zebrafish) ]

Gene ID: 100006778, updated on 27-Mar-2024

Summary

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Official Symbol
il6stprovided by ZNC
Official Full Name
interleukin 6 cytokine family signal transduceprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080104-6
See related
Ensembl:ENSDARG00000104693 AllianceGenome:ZFIN:ZDB-GENE-080104-6
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gp130; sb:eu844
Summary
Predicted to enable cytokine binding activity and cytokine receptor activity. Acts upstream of or within positive regulation of axon regeneration. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including epidermis; immune system; liver; muscle; and sensory system. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; hyperandrogenism; and primary localized cutaneous amyloidosis 2. Orthologous to several human genes including IL6ST (interleukin 6 cytokine family signal transducer). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (5794082..5821649, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (5792588..5820422, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 Neighboring gene peptidylglycine alpha-amidating monooxygenase Neighboring gene ankyrin repeat domain 55 Neighboring gene serine/threonine-protein kinase pim-3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos. Hu H, et al. Toxicol Res (Camb), 2016 Mar 1. PMID 30090375, Free PMC Article
  2. Transcriptome Analysis of Chemically-Induced Sensory Neuron Ablation in Zebrafish. Cox JA, et al. PLoS One, 2016. PMID 26863206, Free PMC Article
  3. Upregulation of leukemia inhibitory factor (LIF) during the early stage of optic nerve regeneration in zebrafish. Ogai K, et al. PLoS One, 2014. PMID 25162623, Free PMC Article
  4. Inflammation-coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos. Duan J, et al. Nanotoxicology, 2018 Jun. PMID 29658397, Free PMC Article
  5. Inflammatory response and blood hypercoagulable state induced by low level co-exposure with silica nanoparticles and benzo[a]pyrene in zebrafish (Danio rerio) embryos. Duan J, et al. Chemosphere, 2016 May. PMID 26943738

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-6 receptor subunit beta
Names
interleukin 6 signal transducer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113504.2 → NP_001106976.1  interleukin-6 receptor subunit beta isoform 1 precursor

    See identical proteins and their annotated locations for NP_001106976.1

    Status: VALIDATED

    Source sequence(s)
    BX321872
    UniProtKB/TrEMBL
    A0A8M1NH01, A8WH79
    Related
    ENSDARP00000133294.1, ENSDART00000161903.2
    Conserved Domains (3) summary
    smart00060
    Location:543 → 624
    FN3; Fibronectin type 3 domain
    cd00063
    Location:230 → 327
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:127 → 219
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_001365484.1 → NP_001352413.1  interleukin-6 receptor subunit beta isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    BX321872
    UniProtKB/TrEMBL
    A0A8M2B2C6, F1QEH5, F1RCZ2
    Conserved Domains (3) summary
    smart00060
    Location:536 → 617
    FN3; Fibronectin type 3 domain
    cd00063
    Location:230 → 327
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:445 → 506
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    5794082..5821649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155489.4 → XP_005155546.1  interleukin-6 receptor subunit beta isoform X1

    UniProtKB/TrEMBL
    F1RCZ2
    Related
    ENSDARP00000130834.1, ENSDART00000166388.2
    Conserved Domains (3) summary
    smart00060
    Location:536 → 617
    FN3; Fibronectin type 3 domain
    cd00063
    Location:230 → 327
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:445 → 506
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein Strain
Heading Accession and Version

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