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atf2 activating transcription factor 2 [ Danio rerio (zebrafish) ]

Gene ID: 100006516, updated on 27-Mar-2024

Summary

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Official Symbol
atf2provided by ZNC
Official Full Name
activating transcription factor 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030911-8
See related
Ensembl:ENSDARG00000023903 AllianceGenome:ZFIN:ZDB-GENE-030911-8
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
atf2l
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cAMP response element binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleus. Orthologous to human ATF2 (activating transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (2343115..2386094)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (2346370..2402122)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene limb and neural patterns a Neighboring gene ATP synthase membrane subunit c locus 3a Neighboring gene uncharacterized LOC110440038 Neighboring gene chimerin 1 Neighboring gene WAS/WASL interacting protein family, member 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Epigallocatechin-3-gallate suppresses neutrophil migration speed in a transgenic zebrafish model accompanied by reduced inflammatory mediators. Nguyen T, et al. J Inflamm Res, 2019. PMID 31695470, Free PMC Article
  2. Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health. Heid J, et al. Sci Rep, 2017 Dec 4. PMID 29203887, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclic AMP-dependent transcription factor ATF-2
XP_009302699.1
XP_009302701.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    2343115..2386094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009304424.3 → XP_009302699.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

    UniProtKB/TrEMBL
    A0A8M3BC84, F1QIZ9
    Related
    ENSDARP00000062291.6, ENSDART00000062292.7
    Conserved Domains (3) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:341 → 401
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:9 → 31
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_009304426.3 → XP_009302701.1  cyclic AMP-dependent transcription factor ATF-2 isoform X2

    See identical proteins and their annotated locations for XP_009302701.1

    UniProtKB/TrEMBL
    A0A8M3AVQ3
    Conserved Domains (1) summary
    cd14687
    Location:154 → 214
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version

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