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itga7 integrin, alpha 7 [ Danio rerio (zebrafish) ]

Gene ID: 100006255, updated on 27-Mar-2024

Summary

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Official Symbol
itga7provided by ZNC
Official Full Name
integrin, alpha 7provided by ZNC
Primary source
ZFIN:ZDB-GENE-070501-10
See related
AllianceGenome:ZFIN:ZDB-GENE-070501-10
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Acts upstream of or within cell-matrix adhesion; muscle attachment; and skeletal muscle tissue development. Is expressed in myoseptum; myotome; skeletal muscle cell; and somite. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; congenital muscular dystrophy due to integrin alpha-7 deficiency; and muscular disease. Orthologous to human ITGA7 (integrin subunit alpha 7). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (62850..86838, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (72120..80824, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene sp1 transcription factor Neighboring gene collagen, type II, alpha 1b Neighboring gene engulfment and cell motility 2 Neighboring gene uncharacterized LOC103908995 Neighboring gene ADP-ribosylation factor GTPase activating protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne muscular dystrophy. Kilroy EA, et al. Elife, 2022 Mar 24. PMID 35324428, Free PMC Article
  2. Lysosomal Function Impacts the Skeletal Muscle Extracellular Matrix. Coffey EC, et al. J Dev Biol, 2021 Nov 23. PMID 34842731, Free PMC Article
  3. NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy. Goody MF, et al. PLoS Biol, 2012. PMID 23109907, Free PMC Article
  4. Knockdown of col22a1 gene in zebrafish induces a muscular dystrophy by disruption of the myotendinous junction. Charvet B, et al. Development, 2013 Nov. PMID 24131632
  5. Analysis of Pax7 expressing myogenic cells in zebrafish muscle development, injury, and models of disease. Seger C, et al. Dev Dyn, 2011 Nov. PMID 21954137

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle attachment IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within muscle attachment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integrin alpha-7

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    62850..86838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358253.2 → XP_017213742.2  integrin alpha-7

    UniProtKB/TrEMBL
    A0A8M6Z1P5
    Conserved Domains (2) summary
    smart00191
    Location:357 → 408
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:450 → 941
    Integrin_alpha2; Integrin alpha
Nucleotide Protein Strain
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