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klf5a Kruppel like factor 5a [ Danio rerio (zebrafish) ]

Gene ID: 100006043, updated on 11-Apr-2024

Summary

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Official Symbol
klf5aprovided by ZNC
Official Full Name
Kruppel like factor 5aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090312-167
See related
Ensembl:ENSDARG00000015506 AllianceGenome:ZFIN:ZDB-GENE-090312-167
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-222f1.2
Summary
Acts upstream of or within digestive tract development. Is expressed in gut; gut epithelium; head; and pharyngeal arch. Orthologous to human KLF5 (Kruppel like factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 1
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (34596823..34612812, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (33864335..33880241, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene LIM domain 7b Neighboring gene Kruppel like factor 12a Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene GPALPP motifs containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The smooth muscle microRNA miR-145 regulates gut epithelial development via a paracrine mechanism. Zeng L, et al. Dev Biol, 2012 Jul 15. PMID 22609551
  2. Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis). Shao M, et al. Oncotarget, 2017 Mar 7. PMID 28032601, Free PMC Article
  3. A Pou5f1/Oct4 dependent Klf2a, Klf2b, and Klf17 regulatory sub-network contributes to EVL and ectoderm development during zebrafish embryogenesis. Kotkamp K, et al. Dev Biol, 2014 Jan 15. PMID 24211655
  4. Genome-wide analysis of the zebrafish Klf family identifies two genes important for erythroid maturation. Xue Y, et al. Dev Biol, 2015 Jul 15. PMID 26015096
  5. Early depletion of primordial germ cells in zebrafish promotes testis formation. Tzung KW, et al. Stem Cell Reports, 2015 Jan 13. PMID 25434820, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Krueppel-like factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    34596823..34612812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001344880.8 → XP_001344916.5  Krueppel-like factor 5

    UniProtKB/TrEMBL
    A0A8M1PZV0, E9QG09
    Related
    ENSDARP00000012722.9, ENSDART00000004361.10
    Conserved Domains (3) summary
    COG5048
    Location:322 → 408
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350 → 369
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:391 → 416
    zf-H2C2_2; Zinc-finger double domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394496.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    203998..218602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471217.1 → XP_021326892.1  Krueppel-like factor 5

    UniProtKB/TrEMBL
    A0A8M9P800
    Conserved Domains (3) summary
    COG5048
    Location:322 → 408
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350 → 369
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:391 → 416
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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