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prkcea protein kinase C, epsilon a [ Danio rerio (zebrafish) ]

Gene ID: 100005075, updated on 11-Apr-2024

Summary

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Official Symbol
prkceaprovided by ZNC
Official Full Name
protein kinase C, epsilon aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8191
See related
Ensembl:ENSDARG00000003008 AllianceGenome:ZFIN:ZDB-GENE-030131-8191
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
prkce; fj59b07; wu:fj59b07
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm. Is expressed in brain; peripheral neurons; and spinal cord. Orthologous to human PRKCE (protein kinase C epsilon). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See prkcea in Genome Data Viewer
Location:
chromosome: 12
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (25640057..25770234)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (25548628..25678871)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene SIX homeobox 3b Neighboring gene SIX homeobox 2b Neighboring gene endothelial PAS domain protein 1a Neighboring gene glutamate dehydrogenase 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Differential expression of PKC isoforms in developing zebrafish. Patten SA, et al. Int J Dev Neurosci, 2007 May. PMID 17403595
  2. Proteolysis regulates cardiomyocyte maturation and tissue integration. Fukuda R, et al. Nat Commun, 2017 Feb 17. PMID 28211472, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein kinase C epsilon type
XP_005156350.1
XP_005156352.1
XP_021336002.1
XP_021336003.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    25640057..25770234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480327.1 → XP_021336002.1  protein kinase C epsilon type isoform X3

    UniProtKB/TrEMBL
    A0A8M9PX29
    Conserved Domains (3) summary
    cd04014
    Location:3 → 135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    cd05591
    Location:418 → 738
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:247 → 299
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. XM_005156295.4 → XP_005156352.1  protein kinase C epsilon type isoform X2

    UniProtKB/TrEMBL
    A0A8M2B2A2
    Conserved Domains (4) summary
    cd04014
    Location:3 → 135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    smart00220
    Location:414 → 674
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:418 → 738
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:246 → 298
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  3. XM_005156293.4 → XP_005156350.1  protein kinase C epsilon type isoform X1

    UniProtKB/TrEMBL
    A0A8M2B2B8, E7F368
    Related
    ENSDARP00000096385.4, ENSDART00000105608.6
    Conserved Domains (4) summary
    cd04014
    Location:3 → 135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    smart00220
    Location:415 → 675
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:419 → 739
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:247 → 299
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  4. XM_021480328.1 → XP_021336003.1  protein kinase C epsilon type isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q913
    Conserved Domains (3) summary
    cd04014
    Location:3 → 135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    cd05591
    Location:417 → 737
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:246 → 298
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
Nucleotide Protein Strain
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