mettl3 methyltransferase like 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mettl3provided by ZNC
Official Full Name: methyltransferase like 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9498
See related: Ensembl:ENSDARG00000012827 AllianceGenome:ZFIN:ZDB-GENE-030131-9498
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: MT-A70; fj82g07; zgc:77093; wu:fj82g07
Summary: Enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity and mRNA (N6-adenosine)-methyltransferase activity. Involved in several processes, including endothelial to hematopoietic transition; mRNA methylation; and negative regulation of Notch signaling pathway. Acts upstream of or within several processes, including Notch signaling pathway involved in arterial endothelial cell fate commitment; hematopoietic stem cell proliferation; and oocyte maturation. Predicted to be located in nuclear speck. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in nucleus. Is expressed in several structures, including gill; heart; liver; nervous system; and pleuroperitoneal region. Used to study infertility. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (21876548..21887071, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (21610210..21620733, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL3-dependent m[6]A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/beta-catenin signaling pathway.
Title: METTL3-dependent m(6)A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway.
m(6)A writer complex promotes timely differentiation and survival of retinal progenitor cells in zebrafish.
Title: m(6)A writer complex promotes timely differentiation and survival of retinal progenitor cells in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fj61g07.x1 (e-PCR)
- UniSTS:188739

fj82g07.x1 (e-PCR)
- UniSTS:200029

fb48g10.x1 (e-PCR)
- UniSTS:190605

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables S-adenosyl-L-methionine binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA m(6)A methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA m(6)A methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mRNA m(6)A methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within Notch signaling pathway involved in arterial endothelial cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within RNA methylation	IEA Inferred from Electronic Annotation more info
involved_in adenosine to inosine editing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial to hematopoietic transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain radial glial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA modification	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type I interferon-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cap-independent translational initiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in primary miRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mRNA modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of meiotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of RNA N6-methyladenosine methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA N6-methyladenosine methyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: N6-adenosine-methyltransferase subunit METTL3

Names: N6-adenosine-methyltransferase 70 kDa subunit

NP_997945.1

EC 2.1.1.348

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.