U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ppp2r2ba protein phosphatase 2, regulatory subunit B, beta a [ Danio rerio (zebrafish) ]

Gene ID: 100001644, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ppp2r2baprovided by ZNC
Official Full Name
protein phosphatase 2, regulatory subunit B, beta aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-101026-5
See related
Ensembl:ENSDARG00000100093 AllianceGenome:ZFIN:ZDB-GENE-101026-5
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 14
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (52524050..52552999, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (51809580..51837321, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene transcription elongation regulator 1a (CA150) Neighboring gene G protein-coupled receptor 151 Neighboring gene ribosomal protein L26 Neighboring gene ATPase H+ transporting V0 subunit e1 Neighboring gene thiosulfate sulfurtransferase like domain containing 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. Lagman D, et al. BMC Evol Biol, 2016 Jun 13. PMID 27296292, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein phosphatase type 2A complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
XP_009289579.1
XP_021336947.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    52524050..52552999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009291304.3 → XP_009289579.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A0R4IJA2, A0A8M3AI53
    Related
    ENSDARP00000133968.1, ENSDART00000170107.2
    Conserved Domains (3) summary
    COG5170
    Location:9 → 434
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:23 → 71
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:11 → 362
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_021481272.1 → XP_021336947.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2

    UniProtKB/TrEMBL
    A0A8M9PZZ4
    Related
    ENSDARP00000070230.5, ENSDART00000075749.6
    Conserved Domains (2) summary
    COG5170
    Location:14 → 428
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:17 → 65
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials