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c5ar1 complement C5a receptor 1 [ Danio rerio (zebrafish) ]

Gene ID: 100000959, updated on 27-Mar-2024

Summary

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Official Symbol
c5ar1provided by ZNC
Official Full Name
complement C5a receptor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-190430-1
See related
Ensembl:ENSDARG00000040319 AllianceGenome:ZFIN:ZDB-GENE-190430-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
C5aR; C5a-R
Orthologs
all
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Genomic context

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Location:
chromosome: 18
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (46794575..46799988)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (46796723..46801714)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909182 Neighboring gene LBH regulator of WNT signaling pathway, like Neighboring gene dapper homolog 3-like Neighboring gene GRAM domain containing 1Bb

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The evolutionary analysis of complement component C5 and the gene co-expression network and putative interaction between C5a and C5a anaphylatoxin receptor (C5AR/CD88) in human and two Cyprinid fish. Li L, et al. Dev Comp Immunol, 2021 Mar. PMID 33290783
  2. Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Natarajan N, et al. Circulation, 2018 May 15. PMID 29348261, Free PMC Article
  3. Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses. Sehring I, et al. Elife, 2022 Jun 24. PMID 35748539, Free PMC Article
  4. Fish complement C8 evolution, functional network analyses, and the theoretical interaction between C8 alpha chain and CD59. Li L, et al. Mol Immunol, 2020 Dec. PMID 33160183
  5. Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish. Lelieveld LT, et al. J Lipid Res, 2022 May. PMID 35315333, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables complement component C5a receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C5a anaphylatoxin chemotactic receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424032.1 → NP_001410961.1  C5a anaphylatoxin chemotactic receptor 1

    Status: VALIDATED

    Source sequence(s)
    CABZ01041494, CABZ01041495
    UniProtKB/Swiss-Prot
    P0C7U5

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    46794575..46799988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159274.4 → XP_005159331.1  C5a anaphylatoxin chemotactic receptor 1

    UniProtKB/Swiss-Prot
    P0C7U5
    Related
    ENSDARP00000059000.4, ENSDART00000059001.6
    Conserved Domains (1) summary
    pfam00001
    Location:50 → 297
    7tm_1; 7 transmembrane receptor (rhodopsin family)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C7U5.1 GenPept UniProtKB/Swiss-Prot:P0C7U5

Gene LinkOut

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