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abl1 c-abl oncogene 1, non-receptor tyrosine kinase [ Danio rerio (zebrafish) ]

Gene ID: 100000720, updated on 11-Apr-2024

Summary

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Official Symbol
abl1provided by ZNC
Official Full Name
c-abl oncogene 1, non-receptor tyrosine kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-100812-9
See related
Ensembl:ENSDARG00000035187 AllianceGenome:ZFIN:ZDB-GENE-100812-9
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable protein tyrosine kinase activity. Predicted to be involved in regulation of apoptotic process. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See abl1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (72144658..72169569)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (71360153..71384745)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene sepiapterin reductase a Neighboring gene exosome component 2 Neighboring gene RAB14, member RAS oncogene family, like Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 54

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Development of BCR-ABL1 Transgenic Zebrafish Model Reproducing Chronic Myeloid Leukemia (CML) Like-Disease and Providing a New Insight into CML Mechanisms. Zizioli D, et al. Cells, 2021 Feb 19. PMID 33669758, Free PMC Article
  2. Nexmifa Regulates Axon Morphogenesis in Motor Neurons in Zebrafish. Zheng YQ, et al. Front Mol Neurosci, 2022. PMID 35431796, Free PMC Article
  3. Conservation and early expression of zebrafish tyrosine kinases support the utility of zebrafish as a model for tyrosine kinase biology. Challa AK, et al. Zebrafish, 2013 Sep. PMID 23234507, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cellular component organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase ABL1
Names
c-abl oncogene 1, receptor tyrosine kinase
XP_005172104.1
XP_005172105.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    72144658..72169569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005172047.4 → XP_005172104.1  tyrosine-protein kinase ABL1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BJW6, F8W2F9
    Related
    ENSDARP00000124744.1, ENSDART00000148626.3
    Conserved Domains (5) summary
    smart00808
    Location:958 → 1081
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:137 → 230
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:79 → 132
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:249 → 511
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:256 → 507
    Pkinase_Tyr; Protein tyrosine kinase

  2. XM_005172048.4 → XP_005172105.1  tyrosine-protein kinase ABL1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BJC3
    Related
    ENSDARP00000125008.1, ENSDART00000149910.2
    Conserved Domains (5) summary
    smart00808
    Location:941 → 1064
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:120 → 213
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:62 → 115
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:232 → 494
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:239 → 490
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein Strain
Heading Accession and Version

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