U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pik3r3b phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [ Danio rerio (zebrafish) ]

Gene ID: 100000252, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
pik3r3bprovided by ZNC
Official Full Name
phosphoinositide-3-kinase, regulatory subunit 3b (gamma)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-743
See related
Ensembl:ENSDARG00000034409 AllianceGenome:ZFIN:ZDB-GENE-040426-743
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pik3r3; zgc:55564; zgc:85710
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in insulin receptor signaling pathway; phosphatidylinositol phosphate biosynthetic process; and regulation of phosphatidylinositol 3-kinase activity. Predicted to act upstream of or within phosphorylation. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in immature eye; nervous system; neural tube; periderm; and somite. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 6
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (33370895..33558977)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (33261168..33574287)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) Neighboring gene tetraspanin 1 Neighboring gene microtubule associated serine/threonine kinase 2 Neighboring gene transmembrane protein 69

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Aryl hydrocarbon receptor activation produces heart-specific transcriptional and toxic responses in developing zebrafish. Carney SA, et al. Mol Pharmacol, 2006 Aug. PMID 16714409
  2. Novel zebrafish caspase-3 substrates. Valencia CA, et al. Biochem Biophys Res Commun, 2007 Sep 21. PMID 17643392
  3. Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish. Sun CC, et al. Biology (Basel), 2021 Aug 10. PMID 34439993, Free PMC Article
  4. The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. Ferg M, et al. EMBO J, 2007 Sep 5. PMID 17703193, Free PMC Article
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC55564, MGC85710, MGC173784, MGC174729

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
phosphatidylinositol 3-kinase regulatory subunit gamma; phosphoinositide-3-kinase, regulatory subunit 3b (gamma)
Names
phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201143.2 → NP_957437.2  phosphoinositide-3-kinase, regulatory subunit 3b (gamma)

    See identical proteins and their annotated locations for NP_957437.2

    Status: PROVISIONAL

    Source sequence(s)
    BC081552
    UniProtKB/TrEMBL
    Q66I41
    Related
    ENSDARP00000040333.5, ENSDART00000040334.6
    Conserved Domains (4) summary
    cd09930
    Location:353 → 456
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:61 → 169
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12925
    Location:174 → 334
    iSH2_PIK3R3; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 3, PIK3R3, also called p55gamma
    pfam16454
    Location:173 → 332
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    33370895..33558977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476737.1 → XP_021332412.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

    UniProtKB/TrEMBL
    A0A8M9PLR5
    Conserved Domains (4) summary
    cd09930
    Location:409 → 512
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:117 → 225
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12925
    Location:230 → 390
    iSH2_PIK3R3; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 3, PIK3R3, also called p55gamma
    cl02570
    Location:2 → 94
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  2. XM_005166277.4 → XP_005166334.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2

    UniProtKB/TrEMBL
    A0A8M2BDR6
    Conserved Domains (4) summary
    cd09930
    Location:327 → 430
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:35 → 143
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    pfam16454
    Location:147 → 306
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
    cl23765
    Location:148 → 308
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394654.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    52280..74015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395258.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    107557..281272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474103.1 → XP_021329778.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3

    UniProtKB/TrEMBL
    A0A8M9PRX4
    Conserved Domains (2) summary
    cl02570
    Location:116 → 307
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:7 → 77
    SH3; Src Homology 3 domain superfamily

Reference GRCz11 ALT_DRER_TU_3

Genomic

  1. NW_018395380.1 Reference GRCz11 ALT_DRER_TU_3

    Range
    236018..257685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous