Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.

Local Unique Identifier

M5500

Xref KEGG Pathways Database

kegg.pathway:hsa03410

Relation in taxon (RO:0002162 )

• NCBITaxon:9606

Relation has part (BFO:0000051 )

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• ncbigene:79661
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• ncbigene:143
• ncbigene:10039
• ncbigene:10038
• ncbigene:5423
• ncbigene:328
• ncbigene:27343
• ncbigene:5424
• ncbigene:5425
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• ncbigene:55247
• ncbigene:6996
• ncbigene:27301
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• ncbigene:10357
• ncbigene:4913
• ncbigene:100506595
• ncbigene:2237
• ncbigene:3978
• ncbigene:4595
• ncbigene:142

Property category_code

C2

Property sub_category_code

CP:KEGG

Property contributor

KEGG

Property exact_source

hsa03410

Property external_details_url

http://www.genome.jp/kegg/pathway/hsa/hsa03410.html